| Primary information |
|---|
| PRRID | PRRID_1295 |
| Ligand Name | Flagellin |
| Source | Salmonella typhimurium strain 14028 (Bacteria) |
| Sequence of ligand | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR |
| Length | 495 |
| Type | Protein |
| Occurence | Natural |
| Role of Ligand | flagellin activates not only macro- phages, monocytes, and dendritic cells but also intestinal and pul- monary epithelial cells, leading to the release of proinflammatory mediators |
| Name of receptor | Toll-like receptor 5 (TLR5) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | monocytes and immature dendritic cells, as well as on epithelial cells |
| Domain | NA |
| Sequence of Receptor | O60602.fasta |
| Swiss prot ID | O60602 |
| Length Of Receptor | 858 |
| Function | activation of TLR5 by flagellin inhibits colon tumor growth in vivo and elicits potent antitumor activity |
| Assay used | ELISA |
| PMID | 24709011 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |
| Primary information |
|---|
| PRRID | PRRID_1295 |
| Ligand Name | Flagellin |
| Source | Salmonella typhimurium strain 14028 (Bacteria) |
| Sequence of ligand | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR |
| Length | 495 |
| Type | Protein |
| Occurence | Natural |
| Role of Ligand | flagellin activates not only macro- phages, monocytes, and dendritic cells but also intestinal and pul- monary epithelial cells, leading to the release of proinflammatory mediators |
| Name of receptor | Toll-like receptor 5 (TLR5) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | monocytes and immature dendritic cells, as well as on epithelial cells |
| Domain | NA |
| Sequence of Receptor | O60602.fasta |
| Swiss prot ID | O60602 |
| Length Of Receptor | 858 |
| Function | activation of TLR5 by flagellin inhibits colon tumor growth in vivo and elicits potent antitumor activity |
| Assay used | ELISA |
| PMID | 24709011 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |