Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0378	Pseudomonas aeruginosa Click for more detail	Pseudomonas aeruginosa (Bacteria)	NA	NA	Whole organism	Natural	P. aeruginosa activates NF-kappaB and MAPK, leads to the producion of proinflammatory cytokines.	Mannose receptor	Mannose receptor (MR)	Human	Monocytes	NA	P22897.fasta	P22897	1456	It has the role in the inflammation.	ELISA	19197942	2009	Pubchem Assay
PRRID_0378	Pseudomonas aeruginosa Click for more detail	Pseudomonas aeruginosa (Bacteria)	NA	NA	Whole organism	Natural	P. aeruginosa activates NF-kappaB and MAPK, leads to the producion of proinflammatory cytokines.	Mannose receptor	Mannose receptor (MR)	Human	Monocytes	NA	P22897.fasta	P22897	1456	It has the role in the inflammation.	ELISA	19197942	2009	Pubchem Assay
PRRID_0399	Streptococcus gordonii Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0399	Streptococcus gordonii Click for more detail	S. gordonii (Bacteria)	NA	NA	Whole organism	Natural	Stimulation elicits the production of tumour necrosis factor (TNF), interleukin (IL)-6, IL-10 and IL-12p70.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Bone-marrow derived Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells.	ELISA	19284500	2009	Pubchem Assay
PRRID_0407	acylated LprA Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Induced IL-8 secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0407	acylated LprA Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Induced IL-8 secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0408	acylated LprG Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Delivery of glycolipds to TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0408	acylated LprG Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Delivery of glycolipds to TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0410	Alpha toxin Click for more detail	S. aureus (Bacteria)	SDYYPRNSVDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWK	71	toxin	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	it activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0410	Alpha toxin Click for more detail	S. aureus (Bacteria)	SDYYPRNSVDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWK	71	toxin	Natural	It‚Äôs binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1Œ≤	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	it activates the inflammasome via NLRP3	NA	20303873	2010	NA
PRRID_0412	Arabinosylated lipoarabinomannan (Ara-LAM) Click for more detail	Mycobacterium tuberculosis (Bacteria)	NA	NA	Glycolipid	Natural	It triggers downstream signalling via MyD88, lead to the ativation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Leishmania donovani infected Mice	macropahge	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis	EMSA and ELISA	20500089	2010	Pubchem Assay
PRRID_0412	Arabinosylated lipoarabinomannan (Ara-LAM) Click for more detail	Mycobacterium tuberculosis (Bacteria)	NA	NA	Glycolipid	Natural	It triggers downstream signalling via MyD88, lead to the ativation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Leishmania donovani infected Mice	macropahge	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis	EMSA and ELISA	20500089	2010	Pubchem Assay
PRRID_0421	Bacterial Antigen Click for more detail	B. abortus 544(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0421	Bacterial Antigen Click for more detail	B. abortus 544(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0422	Bacterial Antigen Click for more detail	B. abortus 545(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	class B scavenger receptor type I (SR-BI)	Scavenger receptor (SR)	Mice	Trophoblast giant cells and J774 cells	NA	Q61009.fasta	Q61009	509	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0422	Bacterial Antigen Click for more detail	B. abortus 545(Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	class B scavenger receptor type I (SR-BI)	Scavenger receptor (SR)	Mice	Trophoblast giant cells and J774 cells	NA	Q61009.fasta	Q61009	509	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0423	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0423	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Trophoblast giant cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	Bacterial Infection assay	20471681	2010	Pubchem Assay
PRRID_0424	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	class B scavenger receptor type I (SR-BI)	Scavenger receptor (SR)	Mice	Trophoblast giant cells and J774 cells	NA	Q61009.fasta	Q61009	509	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	NA	20471681	2010	Pubchem Assay
PRRID_0424	Bacterial Antigen Click for more detail	L. monocytogenes (Bacteria)	NA	NA	NA	Natural	It's binding leads to the bacterial uptake via phagocytosis	class B scavenger receptor type I (SR-BI)	Scavenger receptor (SR)	Mice	Trophoblast giant cells and J774 cells	NA	Q61009.fasta	Q61009	509	It helps in placental defense system by extracellular bacterial antigen uptake via phagocytosis.	NA	20471681	2010	Pubchem Assay
PRRID_0425	Bacterial Antigen Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	It led to the activation of NF-Œ∫B and stimulate the production of cytokines IL-6 and TNF-‚ç∫	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Primary microglia and astrocytes	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It has the immunostimulatory role.	ELISA	20226841	2010	Pubchem Assay
PRRID_0425	Bacterial Antigen Click for more detail	S. aureus (Bacteria)	NA	NA	Whole organism	Natural	It led to the activation of NF-Œ∫B and stimulate the production of cytokines IL-6 and TNF-‚ç∫	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Primary microglia and astrocytes	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It has the immunostimulatory role.	ELISA	20226841	2010	Pubchem Assay
PRRID_0426	Bacterial DNA Click for more detail	Porphyromonas gingivalis and Tannerella forsythia (Bacteria)	NA	NA	Nucleic Acid	Natural	It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytic cells (THP-1 cells)	LRR	Q9NR96.fasta	Q9NR96	1032	Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway.	ELISA	20331800	2010	Pubchem Assay
PRRID_0426	Bacterial DNA Click for more detail	Porphyromonas gingivalis and Tannerella forsythia (Bacteria)	NA	NA	Nucleic Acid	Natural	It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytic cells (THP-1 cells)	LRR	Q9NR96.fasta	Q9NR96	1032	Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway.	ELISA	20331800	2010	Pubchem Assay
PRRID_0428	BsaK Click for more detail	Burkholderia pseudomallei(Bacteria)	MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ	197	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0428	BsaK Click for more detail	Burkholderia pseudomallei(Bacteria)	MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ	197	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0431	Chitin Click for more detail	Bacteria	NA	NA	Carbohydrate	Natural	It triggered the PAMP mediated immunity	CERK1	Pattern recognition receptor (PRR)	Plants	NA	NA	A8R7E6.fasta	A8R7E6	617	It provides the immunity to the plant against the pathogen by recognizing the PAMP	NA	20713980	2010	Pubchem Assay
PRRID_0431	Chitin Click for more detail	Bacteria	NA	NA	Carbohydrate	Natural	It triggered the PAMP mediated immunity	CERK1	Pattern recognition receptor (PRR)	Plants	NA	NA	A8R7E6.fasta	A8R7E6	617	It provides the immunity to the plant against the pathogen by recognizing the PAMP	NA	20713980	2010	Pubchem Assay
PRRID_0432	Chitin Click for more detail	Bacteria	NA	NA	Carbohydrate	Natural	It induce the MAPK activation	Heterodimer of CERK1 and CEBiP	Pattern recognition receptor (PRR)	Rice	NA	NA	NA	NA	NA	It has the role in the inflammation.	NA	20713980	2010	NA
PRRID_0432	Chitin Click for more detail	Bacteria	NA	NA	Carbohydrate	Natural	It induce the MAPK activation	Heterodimer of CERK1 and CEBiP	Pattern recognition receptor (PRR)	Rice	NA	NA	NA	NA	NA	It has the role in the inflammation.	NA	20713980	2010	NA
PRRID_0444	CpG DNA motifs Click for more detail	Virus, Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Inflammation	NA	20692289	2010	NA
PRRID_0444	CpG DNA motifs Click for more detail	Virus, Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Inflammation	NA	20692289	2010	NA
PRRID_0445	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0445	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0449	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Microglia	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvement	NA	20706642	2010	Pubchem Assay
PRRID_0449	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Microglia	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leads to phagocytic ability of microglia toward amyloid protein as well as cognitive improvement	NA	20706642	2010	Pubchem Assay
PRRID_0450	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	APP transgenic Mice	microglia	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	clearance of AŒ≤ from microglial cells	NA	20706642	2010	Pubchem Assay
PRRID_0450	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	APP transgenic Mice	microglia	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	clearance of AŒ≤ from microglial cells	NA	20706642	2010	Pubchem Assay
PRRID_0451	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Their binding induces Th1 response and promote an increase in IFN-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It helps in the immunization of the mice to become more efficient	NA	20636030	2010	Pubchem Assay
PRRID_0451	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Their binding induces Th1 response and promote an increase in IFN-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It helps in the immunization of the mice to become more efficient	NA	20636030	2010	Pubchem Assay
PRRID_0452	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Endosomes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫	NA	20620129	2010	Pubchem Assay
PRRID_0452	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Endosomes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫	NA	20620129	2010	Pubchem Assay
PRRID_0453	CpG ODN 1826 Click for more detail	Bacteria	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	Macropahges	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	20696824	2010	Pubchem Assay
PRRID_0453	CpG ODN 1826 Click for more detail	Bacteria	5‚Äô-tccatgacgttcctgacgtt-3‚Äô	20	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	Macropahges	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	NA	NA	20696824	2010	Pubchem Assay
PRRID_0454	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It delays the onset of prion disease by degrading the prions	NA	20706642	2010	Pubchem Assay
PRRID_0454	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	NA	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It delays the onset of prion disease by degrading the prions	NA	20706642	2010	Pubchem Assay
PRRID_0455	Cpn60.2 Click for more detail	M. tuberculosis (Bacteria)	MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF	540	Protein	Natural	Their binding stabilize the interaction between the M. tuberculosis bacillus and the aveolar macrophage.	cluster of differentiation 43 (CD43)	Pattern recognition receptor (PRR)	C57BL/6 Mice	NA	NA	P15702.fasta	P15702	395	It controls growth of the bacteria in a mouse model of tuberculosis and that TNFa mediates apoptosis of infected CD43+/+ aveolar macrophage,CD43 recognizes the mycobacterial Cpn60.2 which acts as a danger signal for the innate immune system	ELISA	20633027	2010	Pubchem Assay
PRRID_0455	Cpn60.2 Click for more detail	M. tuberculosis (Bacteria)	MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF	540	Protein	Natural	Their binding stabilize the interaction between the M. tuberculosis bacillus and the aveolar macrophage.	cluster of differentiation 43 (CD43)	Pattern recognition receptor (PRR)	C57BL/6 Mice	NA	NA	P15702.fasta	P15702	395	It controls growth of the bacteria in a mouse model of tuberculosis and that TNFa mediates apoptosis of infected CD43+/+ aveolar macrophage,CD43 recognizes the mycobacterial Cpn60.2 which acts as a danger signal for the innate immune system	ELISA	20633027	2010	Pubchem Assay
PRRID_0457	Curli (amyloid fibrils) Click for more detail	E. coli strain MC4100(Bacteria)	MNTLLLLAALSSQITFNTTQQGDVYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISPDDRVKIVVTVSDGQSLHLSQQWPPSSEKS	110	Protein	Natural	The binding of curli mediates the immune respionse cooperatively	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	cervical cancer	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It elicits the immune response via NF-	ELISA	20497180	2010	NA
PRRID_0457	Curli (amyloid fibrils) Click for more detail	E. coli strain MC4100(Bacteria)	MNTLLLLAALSSQITFNTTQQGDVYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISPDDRVKIVVTVSDGQSLHLSQQWPPSSEKS	110	Protein	Natural	The binding of curli mediates the immune respionse cooperatively	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	cervical cancer	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It elicits the immune response via NF-	ELISA	20497180	2010	NA
PRRID_0458	cy2-labeled SitC-His Click for more detail	S. aureus (Bacteria)	NA	NA	Lipoprotein	Natural	It induce release of IL-6 in primary murine keratinocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Keratinocytes	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induce intracellular accumulation of TLR2	NA	20679445	2010	Pubchem Assay
PRRID_0458	cy2-labeled SitC-His Click for more detail	S. aureus (Bacteria)	NA	NA	Lipoprotein	Natural	It induce release of IL-6 in primary murine keratinocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Keratinocytes	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induce intracellular accumulation of TLR2	NA	20679445	2010	Pubchem Assay
PRRID_0459	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8BHB0.fasta	Q8BHB0	953	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0459	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8BHB0.fasta	Q8BHB0	953	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0460	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0460	Derivatives of peptidoglycans Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Peptidoglycan	Natural	The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS)	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Aveolar macrphages	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It leads to the strong neutrophil infiltartion in the infected mice lungs	NA	20685341	2010	Pubchem Assay
PRRID_0461	Dextran Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(C=O)O)O)O)O)O)O)O)O)O)O)O	NA	Carbohydrate	Natural	It is the responsive PAMP for the FcLec5	FcLec5	C type Lectin (CTL/CLR)	Fenneropenaeus chinensis	hepatopancreas	CRD	NA	NA	NA	It elicit the immune response, which leads to the clearance of bacteria	ELISA	20349323	2010	NA
PRRID_0461	Dextran Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(C=O)O)O)O)O)O)O)O)O)O)O)O	NA	Carbohydrate	Natural	It is the responsive PAMP for the FcLec5	FcLec5	C type Lectin (CTL/CLR)	Fenneropenaeus chinensis	hepatopancreas	CRD	NA	NA	NA	It elicit the immune response, which leads to the clearance of bacteria	ELISA	20349323	2010	NA
PRRID_0462	Diacylated Lipopeptide Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	On binding to the receptor it, activates the heterocomplex of TLR2/1 and secretion of cytokines takes place	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	DNA samples from peripheral blood of TB patients	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Immunostimulation and inflammation	NA	20797905	2010	NA
PRRID_0462	Diacylated Lipopeptide Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	On binding to the receptor it, activates the heterocomplex of TLR2/1 and secretion of cytokines takes place	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	DNA samples from peripheral blood of TB patients	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Immunostimulation and inflammation	NA	20797905	2010	NA
PRRID_0463	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	NA
PRRID_0463	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	NA
PRRID_0485	dsDNA Click for more detail	Listeria monocytogenes (Bacteria)	NA	NA	Nucleic Acid	Natural	LRRFIP1 bound Œ≤-catenin and promoted the activation of Œ≤-catenin, which subsequently bound IRF3 which leads to the production of IFN-Œ≤	LRRFIP1	Cytosolic receptor	RAW264.7 cells	cytoplasm	NA	Q3UZ39.fasta	Q3UZ39	729	It induce the production of type I interferon is important for pathogen elimination.	ELISA	20453844	2010	Pubchem Assay
PRRID_0485	dsDNA Click for more detail	Listeria monocytogenes (Bacteria)	NA	NA	Nucleic Acid	Natural	LRRFIP1 bound Œ≤-catenin and promoted the activation of Œ≤-catenin, which subsequently bound IRF3 which leads to the production of IFN-Œ≤	LRRFIP1	Cytosolic receptor	RAW264.7 cells	cytoplasm	NA	Q3UZ39.fasta	Q3UZ39	729	It induce the production of type I interferon is important for pathogen elimination.	ELISA	20453844	2010	Pubchem Assay
PRRID_0493	EF-Tu Click for more detail	Bacteria	MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG	394	Protein	Natural	EF-Tu is the potent activator of EFR	EFR	Pattern recognition receptor (PRR)	Arabidopsis	NA	NA	C0LGT6.fasta	C0LGT6	1031	Induces growth inhibition of Arabidopsis seedling and rapid oxidative burst and defense-related gene expression.	NA	20713980	2010	Pubchem Assay
PRRID_0493	EF-Tu Click for more detail	Bacteria	MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGAARAFDQIDNAPEEKARGITINTSHVEYDTPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEEVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQVLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKVLG	394	Protein	Natural	EF-Tu is the potent activator of EFR	EFR	Pattern recognition receptor (PRR)	Arabidopsis	NA	NA	C0LGT6.fasta	C0LGT6	1031	Induces growth inhibition of Arabidopsis seedling and rapid oxidative burst and defense-related gene expression.	NA	20713980	2010	Pubchem Assay
PRRID_0495	endotoxin-free poly(I:C) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 Mice (experimental model of lung allergic exacerbation)	Airway Epithilium and Dedritic cells	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	It significantly increased the airway hyperresponsiveness, the lung inflammation	ELISA	20505141	2010	Pubchem Assay
PRRID_0495	endotoxin-free poly(I:C) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 Mice (experimental model of lung allergic exacerbation)	Airway Epithilium and Dedritic cells	Leucine-rich Repeat (LRR) Domain	Q99MB1.fasta	Q99MB1	905	It significantly increased the airway hyperresponsiveness, the lung inflammation	ELISA	20505141	2010	Pubchem Assay
PRRID_0497	EprJ and EscI Click for more detail	E. coli(Bacteria)	MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE	95,231	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0497	EprJ and EscI Click for more detail	E. coli(Bacteria)	MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE	95,231	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0506	FimH Click for more detail	Escherichia coli strain EC99 (O78) (Bacteria)	MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ	300	Protein	Natural	It activates both NK cells to induce cytokines [interferon (IFN)-Œ≥ and tumor necrosis factor (TNF)-Œ±] and cytotoxicity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Natural Killer cells	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	It aids innate protection against cancer or microbial infections.	Chromium (51Cr) release assay for NK cytotoxicity	20442710	2010	Pubchem Assay
PRRID_0506	FimH Click for more detail	Escherichia coli strain EC99 (O78) (Bacteria)	MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ	300	Protein	Natural	It activates both NK cells to induce cytokines [interferon (IFN)-Œ≥ and tumor necrosis factor (TNF)-Œ±] and cytotoxicity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Natural Killer cells	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	It aids innate protection against cancer or microbial infections.	Chromium (51Cr) release assay for NK cytotoxicity	20442710	2010	Pubchem Assay
PRRID_0507	FimH Click for more detail	Escherichia coli strain EC99 (O78) (Bacteria)	MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ	300	Protein	Natural	It activates both NK cells to induce cytokines [interferon (IFN)-Œ≥ and tumor necrosis factor (TNF)-Œ±] and cytotoxicity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Natural Killer cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It aids innate protection against cancer or microbial infections.	Chromium (51Cr) release assay for NK cytotoxicity	20442710	2010	Pubchem Assay
PRRID_0507	FimH Click for more detail	Escherichia coli strain EC99 (O78) (Bacteria)	MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYPETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVAIKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAKSQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYARTGGQVTAGNVQSIIGVTFVYQ	300	Protein	Natural	It activates both NK cells to induce cytokines [interferon (IFN)-Œ≥ and tumor necrosis factor (TNF)-Œ±] and cytotoxicity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Natural Killer cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It aids innate protection against cancer or microbial infections.	Chromium (51Cr) release assay for NK cytotoxicity	20442710	2010	Pubchem Assay
PRRID_0508	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0508	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0509	Flagellin Click for more detail	Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18, leads to pathogen clearance and sepsis resistance.	IPAF	NOD-like receptor (NLR)	Human	NA	NA	Q15399.fasta	Q15399	786	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0509	Flagellin Click for more detail	Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18, leads to pathogen clearance and sepsis resistance.	IPAF	NOD-like receptor (NLR)	Human	NA	NA	Q15399.fasta	Q15399	786	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0510	Flagellin Click for more detail	Salmonella muenchen (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates NF-KB and MAPKs and induced significant production of the different cytokines	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Liver, Lung, Kideny, Intestine	Leucine-rich Repeat (LRR) Domain	Q9JLF7.fasta	Q9JLF7	859	It has the role in the inflammation.	NA	20731882	2010	Pubchem Assay
PRRID_0510	Flagellin Click for more detail	Salmonella muenchen (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Activates NF-KB and MAPKs and induced significant production of the different cytokines	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Liver, Lung, Kideny, Intestine	Leucine-rich Repeat (LRR) Domain	Q9JLF7.fasta	Q9JLF7	859	It has the role in the inflammation.	NA	20731882	2010	Pubchem Assay
PRRID_0511	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Macrophages	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It results into the inflammatory response	NA	20719993	2010	Pubchem Assay
PRRID_0511	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Macrophages	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It results into the inflammatory response	NA	20719993	2010	Pubchem Assay
PRRID_0512	Flagellin Click for more detail	P. syringae pv.tabaci (Bacteria)	MALTVNTNVASLNVQKNLGRASDALSTSMTRLSSGLKINSAKDDAAGLQIATKITSQIRGQTMAIKNANDGMSLAQTAEGALQESTNILQRMRELAVQSRNDSNSSTDRDALNKEFTAMSSELTRIAQSTNLNGKNLLDGSASTMTFQVGSNSGASNQITLTLSASFDANTLGVGSAVTIAGSDSTTAETNFSAAIAAIDSALQTINSTRADLGAAQNRLTSTISNLQNINENASAALGRVQDTDFAAETAQLTKQQTLQQASTSVLAQANQLPSAVLKLLQ	282	Protein	Natural	NA	FLS2	Pattern recognition receptor (PRR)	Arabidopsis	NA	NA	Q9FL28.fasta	Q9FL28	1173	Induce medium alkalinization in plant cell cultures from Arabidopsis and growth inhibition of Arabidopsis seedlings.	NA	20713980	2010	Pubchem Assay
PRRID_0512	Flagellin Click for more detail	P. syringae pv.tabaci (Bacteria)	MALTVNTNVASLNVQKNLGRASDALSTSMTRLSSGLKINSAKDDAAGLQIATKITSQIRGQTMAIKNANDGMSLAQTAEGALQESTNILQRMRELAVQSRNDSNSSTDRDALNKEFTAMSSELTRIAQSTNLNGKNLLDGSASTMTFQVGSNSGASNQITLTLSASFDANTLGVGSAVTIAGSDSTTAETNFSAAIAAIDSALQTINSTRADLGAAQNRLTSTISNLQNINENASAALGRVQDTDFAAETAQLTKQQTLQQASTSVLAQANQLPSAVLKLLQ	282	Protein	Natural	NA	FLS2	Pattern recognition receptor (PRR)	Arabidopsis	NA	NA	Q9FL28.fasta	Q9FL28	1173	Induce medium alkalinization in plant cell cultures from Arabidopsis and growth inhibition of Arabidopsis seedlings.	NA	20713980	2010	Pubchem Assay
PRRID_0513	Flagellin Click for more detail	Motile Bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It itriggers the up-regulation of co-stimulatory signals and Ag-presenting molecules	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocytes, mDCs, Langerhans cells, T cells and NK cells	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It leads to the induction of DC maturation.	NA	20713100	2010	Pubchem Assay
PRRID_0513	Flagellin Click for more detail	Motile Bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It itriggers the up-regulation of co-stimulatory signals and Ag-presenting molecules	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	monocytes, mDCs, Langerhans cells, T cells and NK cells	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It leads to the induction of DC maturation.	NA	20713100	2010	Pubchem Assay
PRRID_0514	Flagellin Click for more detail	Salmonella typhimurium(Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	induced the secretion of IL-6 and IL-10	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	peripheral mononuclear cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It has the role in the inflammation.	NA	20703156	2010	Pubchem Assay
PRRID_0514	Flagellin Click for more detail	Salmonella typhimurium(Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	induced the secretion of IL-6 and IL-10	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	peripheral mononuclear cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It has the role in the inflammation.	NA	20703156	2010	Pubchem Assay
PRRID_0516	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫	NA	20620129	2010	Pubchem Assay
PRRID_0516	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫	NA	20620129	2010	Pubchem Assay
PRRID_0517	Flagellin Click for more detail	Bacterial strains	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Upon binding of flagellin to FLS2 leads to the recruitment of adapter proteins.	FLS2	Pattern recognition receptor (PRR)	Arabidopsis	NA	NA	Q9FL28.fasta	Q9FL28	1173	it provides the resistance to the bacterial pathogens	NA	20610395	2010	Pubchem Assay
PRRID_0517	Flagellin Click for more detail	Bacterial strains	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Upon binding of flagellin to FLS2 leads to the recruitment of adapter proteins.	FLS2	Pattern recognition receptor (PRR)	Arabidopsis	NA	NA	Q9FL28.fasta	Q9FL28	1173	it provides the resistance to the bacterial pathogens	NA	20610395	2010	Pubchem Assay
PRRID_0518	Flagellin Click for more detail	Legionella pneumophila (Bacteria)	MIINHNLAAINSHRVLKFQNEEVSKNMEKLSSGMRINRAGDDASGLAVSEKMRTQVNGLRQAERNTEDGMSLIQTTEGFLQESNDIIQRIRTLAIQSSNGIYTDEDRQMIQVEVSQLIDEVDRIASQAEFNKMNLLQGDFARGSRATSMWFHLGPNMHQRERVFIATMTARALNLKGQSGDLLSLSTADKSNDAIGTLDAALTRISKQRANLGAYFNRLEHAAKGLMNAYENTQASESRIRDADMAEETVAFTKNQILVQSGTAMLAQANVRPQGVLSLLR	281	Protein	Natural	Their bining activate the caspase-1 platform	Naip5	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	implicated in the restriction of Legionella growth in macrophages,	NA	20605429	2010	NA
PRRID_0518	Flagellin Click for more detail	Legionella pneumophila (Bacteria)	MIINHNLAAINSHRVLKFQNEEVSKNMEKLSSGMRINRAGDDASGLAVSEKMRTQVNGLRQAERNTEDGMSLIQTTEGFLQESNDIIQRIRTLAIQSSNGIYTDEDRQMIQVEVSQLIDEVDRIASQAEFNKMNLLQGDFARGSRATSMWFHLGPNMHQRERVFIATMTARALNLKGQSGDLLSLSTADKSNDAIGTLDAALTRISKQRANLGAYFNRLEHAAKGLMNAYENTQASESRIRDADMAEETVAFTKNQILVQSGTAMLAQANVRPQGVLSLLR	281	Protein	Natural	Their bining activate the caspase-1 platform	Naip5	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	implicated in the restriction of Legionella growth in macrophages,	NA	20605429	2010	NA
PRRID_0519	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It's binding induces the production of IL6, IL8, MMP3 and MMP4	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Fibroblast Like Synoviocytes (FLS)	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction	ELISA	20571165	2010	Pubchem Assay
PRRID_0519	Flagellin Click for more detail	Flagellated bacteria (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	It's binding induces the production of IL6, IL8, MMP3 and MMP4	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Fibroblast Like Synoviocytes (FLS)	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction	ELISA	20571165	2010	Pubchem Assay
PRRID_0520	Flagellin (L94A) Click for more detail	Pseudomonas aeruginosa (Bacteria)	GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP	434	Protein	Natural	It elicits EGFR signaling in a TGF-a‚Äìrelated pathway, which leads to the secretion of cytokine/chemokine and production of antimicrobial peptides (AMPs).	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Human corneal epithelial cells (HCECs)	LRR	O60602.fasta	O60602	858	It stimulates mucosal surface innate immune response.	ELISA	20195469	2010	Pubchem Assay
PRRID_0520	Flagellin (L94A) Click for more detail	Pseudomonas aeruginosa (Bacteria)	GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP	434	Protein	Natural	It elicits EGFR signaling in a TGF-a‚Äìrelated pathway, which leads to the secretion of cytokine/chemokine and production of antimicrobial peptides (AMPs).	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Human corneal epithelial cells (HCECs)	LRR	O60602.fasta	O60602	858	It stimulates mucosal surface innate immune response.	ELISA	20195469	2010	Pubchem Assay
PRRID_0521	flagellin and functional type III or Type IV secretion systems Click for more detail	Salmonella (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Their bining activate the caspase-1 platform	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It helps in restriction of salmonella growth in macrophages,	NA	20605429	2010	NA
PRRID_0521	flagellin and functional type III or Type IV secretion systems Click for more detail	Salmonella (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Their bining activate the caspase-1 platform	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It helps in restriction of salmonella growth in macrophages,	NA	20605429	2010	NA

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