Primary information |
---|
PRRID | PRRID_0495 |
Ligand Name | endotoxin-free poly(I:C) |
Source | Bacteria |
Sequence of ligand | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O |
Length | NA |
Type | Nucleic Acid |
Occurence | Synthetic |
Role of Ligand | It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11 |
Name of receptor | Toll-like receptor 3 (TLR3) |
Type of receptor | Toll-like receptor (TLR) |
Source | C57BL/6 Mice (experimental model of lung allergic exacerbation) |
Localization | Airway Epithilium and Dedritic cells |
Domain | Leucine-rich Repeat (LRR) Domain |
Sequence of Receptor | Q99MB1.fasta |
Swiss prot ID | Q99MB1 |
Length Of Receptor | 905 |
Function | It significantly increased the airway hyperresponsiveness, the lung inflammation |
Assay used | ELISA |
PMID | 20505141 |
Year of Publication | 2010 |
Pubchem assay | Pubchem Assay |
Primary information |
---|
PRRID | PRRID_0495 |
Ligand Name | endotoxin-free poly(I:C) |
Source | Bacteria |
Sequence of ligand | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O |
Length | NA |
Type | Nucleic Acid |
Occurence | Synthetic |
Role of Ligand | It activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11 |
Name of receptor | Toll-like receptor 3 (TLR3) |
Type of receptor | Toll-like receptor (TLR) |
Source | C57BL/6 Mice (experimental model of lung allergic exacerbation) |
Localization | Airway Epithilium and Dedritic cells |
Domain | Leucine-rich Repeat (LRR) Domain |
Sequence of Receptor | Q99MB1.fasta |
Swiss prot ID | Q99MB1 |
Length Of Receptor | 905 |
Function | It significantly increased the airway hyperresponsiveness, the lung inflammation |
Assay used | ELISA |
PMID | 20505141 |
Year of Publication | 2010 |
Pubchem assay | Pubchem Assay |