Detailed description page of PRRDB2.0

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PRRID_0495 details
Primary information
PRRIDPRRID_0495
Ligand Nameendotoxin-free poly(I:C)
SourceBacteria
Sequence of ligandC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of LigandIt activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11
Name of receptorToll-like receptor 3 (TLR3)
Type of receptorToll-like receptor (TLR)
Source C57BL/6 Mice (experimental model of lung allergic exacerbation)
LocalizationAirway Epithilium and Dedritic cells
DomainLeucine-rich Repeat (LRR) Domain
Sequence of ReceptorQ99MB1.fasta
Swiss prot IDQ99MB1
Length Of Receptor905
FunctionIt significantly increased the airway hyperresponsiveness, the lung inflammation
Assay usedELISA
PMID20505141
Year of Publication2010
Pubchem assayPubchem Assay
Primary information
PRRIDPRRID_0495
Ligand Nameendotoxin-free poly(I:C)
SourceBacteria
Sequence of ligandC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of LigandIt activates the TLR3-TRIF pathway, lead to the production of IL-5, IL-13 and CCL11
Name of receptorToll-like receptor 3 (TLR3)
Type of receptorToll-like receptor (TLR)
Source C57BL/6 Mice (experimental model of lung allergic exacerbation)
LocalizationAirway Epithilium and Dedritic cells
DomainLeucine-rich Repeat (LRR) Domain
Sequence of ReceptorQ99MB1.fasta
Swiss prot IDQ99MB1
Length Of Receptor905
FunctionIt significantly increased the airway hyperresponsiveness, the lung inflammation
Assay usedELISA
PMID20505141
Year of Publication2010
Pubchem assayPubchem Assay