| Primary information |
|---|
| PRRID | PRRID_0455 |
| Ligand Name | Cpn60.2 |
| Source | M. tuberculosis (Bacteria) |
| Sequence of ligand | MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF |
| Length | 540 |
| Type | Protein |
| Occurence | Natural |
| Role of Ligand | Their binding stabilize the interaction between the M. tuberculosis bacillus and the aveolar macrophage. |
| Name of receptor | cluster of differentiation 43 (CD43) |
| Type of receptor | Pattern recognition receptor (PRR) |
| Source | C57BL/6 Mice |
| Localization | NA |
| Domain | NA |
| Sequence of Receptor | P15702.fasta |
| Swiss prot ID | P15702 |
| Length Of Receptor | 395 |
| Function | It controls growth of the bacteria in a mouse model of tuberculosis and that TNFa mediates apoptosis of infected CD43+/+ aveolar macrophage,CD43 recognizes the mycobacterial Cpn60.2 which acts as a danger signal for the innate immune system |
| Assay used | ELISA |
| PMID | 20633027 |
| Year of Publication | 2010 |
| Pubchem assay | Pubchem Assay |
| Primary information |
|---|
| PRRID | PRRID_0455 |
| Ligand Name | Cpn60.2 |
| Source | M. tuberculosis (Bacteria) |
| Sequence of ligand | MAKTIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVTLLQAAPTLDELKLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVPGGGDMGGMDF |
| Length | 540 |
| Type | Protein |
| Occurence | Natural |
| Role of Ligand | Their binding stabilize the interaction between the M. tuberculosis bacillus and the aveolar macrophage. |
| Name of receptor | cluster of differentiation 43 (CD43) |
| Type of receptor | Pattern recognition receptor (PRR) |
| Source | C57BL/6 Mice |
| Localization | NA |
| Domain | NA |
| Sequence of Receptor | P15702.fasta |
| Swiss prot ID | P15702 |
| Length Of Receptor | 395 |
| Function | It controls growth of the bacteria in a mouse model of tuberculosis and that TNFa mediates apoptosis of infected CD43+/+ aveolar macrophage,CD43 recognizes the mycobacterial Cpn60.2 which acts as a danger signal for the innate immune system |
| Assay used | ELISA |
| PMID | 20633027 |
| Year of Publication | 2010 |
| Pubchem assay | Pubchem Assay |