Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID1019 | SequenceKETWWETWWTEWSQP KKKRKV | NamePep-1 | Nature of peptide or cargoCell penetrating peptide | AssayIn vivo imaging | Tissue permeabilitySignificant permeability of the peptide can be seen in in vivo images | Tissue SampleMouse skin cells | PUBMED ID23601371 |
| ID1122 | SequenceGIGKFLKKAKKFG KAFVKILKK | NamePexiganan | Nature of peptide or cargoAntimicrobial, Diabetic Foot Ulcers | AssayWound healing, infection progression, and the number of amputations required were calculated statistically | Tissue permeabilityClinical improvement rates were (85%–90%), Overall microbiological eradication rates (42%–47%) | Tissue SampleDiabetic Foot Ulcers | PUBMED ID18990064 |
| ID1127 | SequenceGIGKFLHSAKKFGKA FVGEIMNS | NameMagainin | Nature of peptide or cargoAntimicrobial | AssayFranz diffusion cell | Tissue permeabilityThe results suggest that positively charged magainin facilitated transdermal transport of negatively charged fluorescein due to electrostatic attraction at pH 7.4 and results in 35 fold increase in the permeation of maganine by the NLS control formulation (i.e., from an average of 0.037μg to 1.302 μg of fluorescein), but as the attraction decreased with increasing pH, the skin permeability enhancement decreased as well | Tissue SampleHuman cadaver skin | PUBMED ID18601987 |
| ID1128 | SequenceGIGKFLHSAKKFGKA FVGEIMNS | NameMagainin | Nature of peptide or cargoAntimicrobial | AssayFranz diffusion cell | Tissue permeabilityThe results suggest that positively charged magainin facilitated transdermal transport of positively charged granisetron due to electrostatic attraction at pH 10 and results in 92–fold increase in the permeation of magnine (i.e., from and average of 2.23 μg to 205.55 μg of granisetron), but as the attraction decreased with decreasing pH, the skin permeability enhancement decreased as well | Tissue SampleHuman cadaver skin | PUBMED ID18601987 |
| ID1129 | SequenceGIGKFLHSAKKFGKA FVGEIMNS | NameMagainin | Nature of peptide or cargoAntimicrobial | AssayMulti-photon excitation microscopy | Tissue permeabilityThe increase in permeation of fluorescein Faciliated by magnine can be seen the the microscopic images | Tissue SampleHuman cadaver skin | PUBMED ID18601987 |
| ID1130 | SequenceGIGKFLHSAKKFGKA FVGEIMNS | NameMagainin | Nature of peptide or cargoAntimicrobial | AssayMulti-photon excitation microscopy | Tissue permeabilityThe increase in permeation of granisetron faciliated by magnine can be seen the the microscopic images | Tissue SampleHuman cadaver skin | PUBMED ID18601987 |
| ID1139 | SequenceGIGKFLHSAKKFGKA FVGEIMNS | NameMagainin | Nature of peptide or cargoAntimicrobial | AssayFranz cell system, Multi-photon microscopy | Tissue permeabilitySkin permeability 1.5x 103cm/h in presence of chemical enhancer,C o-administration of magainin and NLS-ethanol led to extensive magainin penetration throughout the stratum corneum which could be easily visualised in the microscopic images | Tissue SampleHuman cadaver skin | PUBMED ID17628164 |
| ID1198 | SequenceRQIKIWFQNRRMKWK KSIINFEKL | NameANTP-OVA8 (OVA257–264 linked to Antennapedia transduction sequence) | Nature of peptide or cargoANTP-OVA8 enhances the delivery of the antigen through the skin and promotes the generation of CTL | AssayHistochemical staining | Tissue permeabilityPenetration of the antigen across skin surface with strong staining of all skin tissue layers. The penetration was rapid and detectable at 30 min | Tissue SampleTape-stripped ears of mice | PUBMED ID15121311 |
| ID1289 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 57% (32 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1290 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 55% (23 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1291 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 54% (21 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1292 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 56% (20 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1293 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 58% (16 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1294 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 61% (14 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1357 | SequenceAGYKPDEGKRGDACE GDSGGPFV | NameTRAP-508 | Nature of peptide or cargoThromboplastin activation product of prothrombin with high clotting and esterase activity. | AssayHistological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength. | Tissue permeability41% increase in breaking strength, P< 0.001, at 500 pmol/cm, histology demonstrated a more advanced state of healing, ratio test/saline control of incisional breaking strength is 1.37±0.39 | Tissue SampleA single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose. | PUBMED ID1373740 |
| ID1358 | SequenceAGYKPDEGKRGDACE GDSGGPFV | NameTRAP-508b | Nature of peptide or cargoThromboplastin activation product of prothrombin with high clotting and esterase activity. | AssayHistological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength. | Tissue permeabilityIncreased breaking strength > 80% over control values at day 7, P<0.001 | Tissue SampleA single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose. | PUBMED ID1373740 |
| ID1359 | SequenceAGYKPDEGKRGDACE GDSGGPFV | NameTRAP-508b | Nature of peptide or cargoThromboplastin activation product of prothrombin with high clotting and esterase activity. | AssayHistological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength. | Tissue permeability39% increase over control breaking strength(P < 0.001) | Tissue SampleA single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose. | PUBMED ID1373740 |
| ID1360 | SequenceAGYKPDEGKRGDACE GDSGGPFV | NameTRAP-508b | Nature of peptide or cargoThromboplastin activation product of prothrombin with high clotting and esterase activity. | AssayHistological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength. | Tissue permeability18% increase over control breaking strength (P< 0.002) | Tissue SampleA single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose. | PUBMED ID1373740 |
| ID1404 | SequenceAGYKPDEGKRGDACE GDSGGPFV | NameTRAP 508 (Thrombin receptor-activating peptide) | Nature of peptide or cargoMimics many effects of thrombin | AssayAngiography and histology | Tissue permeabilityAfter 7 days, incisions treated with a single application of alpha-thrombin(10 pmol or 0.3310 micro gram/cm of incision) showed a 26% increase in breaking strength over those treated with PBS alone with a P value of <0.013. But, a single application of TRAP-508 worked even better than thrombin increasing breaking strength 41% over controls (P<0.001, at 500 pmol/cm). | Tissue SampleMice skin | PUBMED ID1373740 |
| ID1434 | SequenceAEKKDEGPYRMEHFR WGSPPKD | Nameβ-MSH (β-Melanocyte-stimulating hormone) | Nature of peptide or cargoMSH stimulate the production and release of melanin (a process referred to as melanogenesis) by melanocytes in skin and hair. MSH actions in the brain have effects on appetite and sexual arousal. | AssayOsmolarity and tear volume measurements | Tissue permeabilityOsmolarity measurements: t=0 min., β-MSH/Buffer=310/311mOsm/l; t=6 min., β-MSH/Buffer=301.5/306mOsm/l; t=16 min., β-MSH/Buffer=306/308mOsm/l; Volume measurement: β-MSH/Buffer= 14µl/56.1µl | Tissue SampleEyes of male and female New Zealand white rabbits with closed lacrimal gland excretory duct | PUBMED ID2365569 |
| ID1545 | SequenceGRKKRRQRRRPPQ-P DALKSRTLR | Nameμ-N2-10-2 (HIV-Nμ) (μ-calpain peptide ) | Nature of peptide or cargoNot mentioned | AssayImmunofluorescence,TUNEL staining | Tissue permeabilityTUNEL positive cells reduced by 50% in HIV-nu traeted retinas | Tissue Samplecornea of the eye | PUBMED ID22885154 |