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Details of TopicalPdb ID 1404

PRIMARY INFORMATION
ID1404
PMID1373740
Year1992
SequenceAGYKPDEGKRGDACE
GDSGGPFV
NameTRAP 508 (Thrombin receptor-activating peptide)
Length23
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic
Nature of Peptide/CargoMimics many effects of thrombin
MechanismSynthetic
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayAngiography and histology
EnhancerPBS , pH 7.4
Properties of enhancerNot mentioned
ConcentrationTRAP-508(1.33gg or 500 pmol/cm).
Incubation time7 Days
Tissue permeability (value with units)After 7 days, incisions treated with a single application of alpha-thrombin(10 pmol or 0.3310 micro gram/cm of incision) showed a 26% increase in breaking strength over those treated with PBS alone with a P value of <0.013. But, a single application of TRAP-508 worked even better than thrombin increasing breaking strength 41% over controls (P<0.001, at 500 pmol/cm).
Tissue SampleMice skin
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](C)C(=O)NCC(=O)N[C@@H]
(Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[NH3])C
(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]
(CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCC[NH3])
C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CC
(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N
[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C
(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N1CCC
[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C=O