| ID | 1404 | |
| PMID | 1373740 | |
| Year | 1992 | |
| Sequence | AGYKPDEGKRGDACE GDSGGPFV | |
| Name | TRAP 508 (Thrombin receptor-activating peptide) | |
| Length | 23 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Synthetic | |
| Nature of Peptide/Cargo | Mimics many effects of thrombin | |
| Mechanism | Synthetic | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Angiography and histology | |
| Enhancer | PBS , pH 7.4 | |
| Properties of enhancer | Not mentioned | |
| Concentration | TRAP-508(1.33gg or 500 pmol/cm). | |
| Incubation time | 7 Days | |
| Tissue permeability (value with units) | After 7 days, incisions treated with a single application of alpha-thrombin(10 pmol or 0.3310 micro gram/cm of incision) showed a 26% increase in breaking strength over those treated with PBS alone with a P value of <0.013. But, a single application of TRAP-508 worked even better than thrombin increasing breaking strength 41% over controls (P<0.001, at 500 pmol/cm). | |
| Tissue Sample | Mice skin | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N[C@@H](C)C(=O)NCC(=O)N[C@@H] (Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[NH3])C (=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H] (CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCC[NH3]) C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CC (=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N [C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C (=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N1CCC [C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C=O | |