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Details of TopicalPdb ID 1198

PRIMARY INFORMATION
ID	1198
PMID	15121311
Year	2003
Sequence	RQIKIWFQNRRMKWK KSIINFEKL
Name	ANTP-OVA8 (OVA257–264 linked to Antennapedia transduction sequence)
Length	24
N-Terminal Modification	Biotin
C-Terminal Modification	Free
Linear/ Cyclic	Linear
Chirality	L
Chemical Modification	None
Origin of Peptide	OVA257–264 linked to Antennapedia transduction sequence
Nature of Peptide/Cargo	ANTP-OVA8 enhances the delivery of the antigen through the skin and promotes the generation of CTL
Mechanism	Not mentioned
Cargo Sequence/Structure	None
Name of cargo	Not applicable
Assay	Histochemical staining
Enhancer	Tape-stripped skin
Properties of enhancer	Not mentioned
Concentration	1mM ANTP-OVA8
Incubation time	30, 60, 90 min
Tissue permeability (value with units)	Penetration of the antigen across skin surface with strong staining of all skin tissue layers. The penetration was rapid and detectable at 30 min
Tissue Sample	Tape-stripped ears of mice
Ex vivo/In vivo/In vitro	in vivo
SECONDARY INFORMATION
STRUCTURE	Predicted Structure
SMILES	N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC) C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12) C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC (=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O) N[C@@H](CCSC)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C (=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CO)C(=O) N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N [C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CC(C)C)C=O