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Details of TopicalPdb ID 1359

PRIMARY INFORMATION
ID1359
PMID1373740
Year1992
SequenceAGYKPDEGKRGDACE
GDSGGPFV
NameTRAP-508b
Length23
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideHuman thrombin derivative
Nature of Peptide/CargoThromboplastin activation product of prothrombin with high clotting and esterase activity.
MechanismThey bind thrombin receptors and activate mitogenic signals.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayHistological examination and numerical scoring of cellular and tissue parameters of wound healing and determining incisional breaking strength.
EnhancerNone
Properties of enhancerNot applicable
Concentration200g/ml
Incubation time14 days
Tissue permeability (value with units)39% increase over control breaking strength(P < 0.001)
Tissue SampleA single 6-cm vertical incision was made on the dorsal midline or a parallel pair of 6-cm incisions were cut 1.5 cm to either side of the midline of acclimatized adult male Harlan Sprague-Dawley rats. The wound was closed with three simple interrupted sutures placed 1.5cm apart and later received a single peptide dose.
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[NH3])C(=O)
N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCC[NH3])C(=O)
N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)
N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)
N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C
(=O)N[C@@H](C(C)C)C=O