Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0027 | poly(I:G) Click for more detail | synthetic oligonucleotide (others) | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Immunostimulant | Scavenger receptor A II | Scavenger receptor (SR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 8429030 | 1993 | NA |
| PRRID_0027 | poly(I:G) Click for more detail | synthetic oligonucleotide (others) | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Immunostimulant | Scavenger receptor A II | Scavenger receptor (SR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 8429030 | 1993 | NA |
| PRRID_0028 | poly(I:G) Click for more detail | synthetic oligonucleotide (others) | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Immunostimulant | Scavenger receptor A II | Scavenger receptor (SR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 8429030 | 1993 | NA |
| PRRID_0028 | poly(I:G) Click for more detail | synthetic oligonucleotide (others) | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Immunostimulant | Scavenger receptor A II | Scavenger receptor (SR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 8429030 | 1993 | NA |
| PRRID_0081 | CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | induce type I interferons (IFN) and other cytokines production. | NA | 11130078 | 2000 | Pubchem Assay |
| PRRID_0081 | CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | induce type I interferons (IFN) and other cytokines production. | NA | 11130078 | 2000 | Pubchem Assay |
| PRRID_0099 | dsRNA Click for more detail | Type I Lang mammalian reovirus (virus) | NA | NA | Nucleic Acid | Natural | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | (HEK293 t cells) | NA | O15455.fasta | O15455 | 904 | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. | EMSA | 11607032 | 2001 | Pubchem Assay |
| PRRID_0099 | dsRNA Click for more detail | Type I Lang mammalian reovirus (virus) | NA | NA | Nucleic Acid | Natural | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | (HEK293 t cells) | NA | O15455.fasta | O15455 | 904 | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. | EMSA | 11607032 | 2001 | Pubchem Assay |
| PRRID_0111 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | (HEK293 t cells) | NA | O15455.fasta | O15455 | 904 | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. | EMSA | 11607032 | 2001 | Pubchem Assay |
| PRRID_0111 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | (HEK293 t cells) | NA | O15455.fasta | O15455 | 904 | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. | EMSA | 11607032 | 2001 | Pubchem Assay |
| PRRID_0148 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0148 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0149 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0149 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0150 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0150 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0151 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0151 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0152 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0152 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0153 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0153 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0154 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0154 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0155 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0155 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0156 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0156 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0157 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0157 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0158 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0158 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0159 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0159 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0160 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0160 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0161 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0161 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0162 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0162 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0177 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | NA | P58681.fasta | P58681 | 1050 | It leads to the endosomal maturation. | ELISA | 14579267 | 2003 | Pubchem Assay |
| PRRID_0177 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | NA | P58681.fasta | P58681 | 1050 | It leads to the endosomal maturation. | ELISA | 14579267 | 2003 | Pubchem Assay |
| PRRID_0186 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | Spleenocytes | NA | P58682.fasta | P58682 | 1032 | It leads to the endosomal maturation. | ELISA | 14579267 | 2003 | Pubchem Assay |
| PRRID_0186 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | Spleenocytes | NA | P58682.fasta | P58682 | 1032 | It leads to the endosomal maturation. | ELISA | 14579267 | 2003 | Pubchem Assay |
| PRRID_0195 | Double-stranded ribonucleic acid (dsRNA) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | O15455.fasta | O15455 | 904 | production of pro-inflammatory cytokines | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0195 | Double-stranded ribonucleic acid (dsRNA) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | O15455.fasta | O15455 | 904 | production of pro-inflammatory cytokines | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0196 | dsRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0196 | dsRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0211 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0211 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0212 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NR97.fasta | Q9NR97 | 1041 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0212 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NR97.fasta | Q9NR97 | 1041 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0213 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 14976261 | 2004 | NA |
| PRRID_0213 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 14976261 | 2004 | NA |
| PRRID_0214 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 14976261 | 2004 | NA |
| PRRID_0214 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 14976261 | 2004 | NA |
| PRRID_0223 | Microparticles containingOVAand poly-U Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | BMDCs | NA | P58681.fasta | P58681 | 1050 | It stimulates proinflammatory and antiviral responses. | ELISA | 16278038 | 2005 | Pubchem Assay |
| PRRID_0223 | Microparticles containingOVAand poly-U Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | BMDCs | NA | P58681.fasta | P58681 | 1050 | It stimulates proinflammatory and antiviral responses. | ELISA | 16278038 | 2005 | Pubchem Assay |
| PRRID_0224 | Microparticles containingOVAand poly-U Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | BMDCs | NA | P58682.fasta | P58682 | 1032 | It stimulates proinflammatory and antiviral responses. | ELISA | 16278038 | 2005 | Pubchem Assay |
| PRRID_0224 | Microparticles containingOVAand poly-U Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | BMDCs | NA | P58682.fasta | P58682 | 1032 | It stimulates proinflammatory and antiviral responses. | ELISA | 16278038 | 2005 | Pubchem Assay |
| PRRID_0240 | CpG-ODNs Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0240 | CpG-ODNs Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0245 | IC31 Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0245 | IC31 Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0248 | Poly (I:C)-LANAC Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Adjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Spleen and lung cells | NA | Q99MB1.fasta | Q99MB1 | 905 | TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags. | ELISA | 16751377 | 2006 | Pubchem Assay |
| PRRID_0248 | Poly (I:C)-LANAC Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Adjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Spleen and lung cells | NA | Q99MB1.fasta | Q99MB1 | 905 | TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags. | ELISA | 16751377 | 2006 | Pubchem Assay |
| PRRID_0249 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0249 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0252 | dsDNA Click for more detail | Adenovirus(virus) | NA | NA | Nucleic Acid | Natural | Adenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Plasmacytoid dendritic cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | This leads to the inflammatory response. | ELISA | 17229689 | 2007 | Pubchem Assay |
| PRRID_0252 | dsDNA Click for more detail | Adenovirus(virus) | NA | NA | Nucleic Acid | Natural | Adenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Plasmacytoid dendritic cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | This leads to the inflammatory response. | ELISA | 17229689 | 2007 | Pubchem Assay |
| PRRID_0263 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | elicit innate immune response | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | macrophages and dendritic cells | NA | O15455.fasta | O15455 | 904 | Induces pro-inflammatory cytokine response | NA | 17573354 | 2007 | Pubchem Assay |
| PRRID_0263 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | elicit innate immune response | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | macrophages and dendritic cells | NA | O15455.fasta | O15455 | 904 | Induces pro-inflammatory cytokine response | NA | 17573354 | 2007 | Pubchem Assay |
| PRRID_0265 | Unmethylated CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0265 | Unmethylated CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0266 | 3M-003 Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | NA | NA | NA | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | NA |
| PRRID_0266 | 3M-003 Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | NA | NA | NA | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | NA |
| PRRID_0267 | 3M002 (CL075) Click for more detail | NA | CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58682.fasta | P58682 | 1032 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0267 | 3M002 (CL075) Click for more detail | NA | CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58682.fasta | P58682 | 1032 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0268 | 852A Click for more detail | NA | CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O | NA | Nucleic Acid | Synthetic | It has stimulated the production of interferon-‚ç∫ (IFN-‚ç∫), IFN-inducible protein-10 (IP-10), interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),IL-12p70, IL-18, and IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood mononuclear cells (PBMC) | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It has inhibited the proliferation of tumor cell lines Hs294T and 769-P. | ELISA | 18439103 | 2008 | Pubchem Assay |
| PRRID_0268 | 852A Click for more detail | NA | CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O | NA | Nucleic Acid | Synthetic | It has stimulated the production of interferon-‚ç∫ (IFN-‚ç∫), IFN-inducible protein-10 (IP-10), interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),IL-12p70, IL-18, and IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood mononuclear cells (PBMC) | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It has inhibited the proliferation of tumor cell lines Hs294T and 769-P. | ELISA | 18439103 | 2008 | Pubchem Assay |
| PRRID_0269 | 852A Click for more detail | NA | CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O | NA | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | Pubchem Assay |
| PRRID_0269 | 852A Click for more detail | NA | CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O | NA | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | Pubchem Assay |
| PRRID_0274 | Cardioprotectant adenosine Click for more detail | NA | NA | NA | Nucleic Acid | Natural | Adenosine increases matrix metalloproteinase-9 production by primary macrophages from healthy volunteers and myocardial infarction patients. | Adenosine-A3 receptor | G-protein-coupled receptors (GPCR) | Human | PBMCs | NA | P0DMS8.fasta | P0DMS8 | 318 | It improves the revascularization. | ELISA | 18653544 | 2008 | Pubchem Assay |
| PRRID_0274 | Cardioprotectant adenosine Click for more detail | NA | NA | NA | Nucleic Acid | Natural | Adenosine increases matrix metalloproteinase-9 production by primary macrophages from healthy volunteers and myocardial infarction patients. | Adenosine-A3 receptor | G-protein-coupled receptors (GPCR) | Human | PBMCs | NA | P0DMS8.fasta | P0DMS8 | 318 | It improves the revascularization. | ELISA | 18653544 | 2008 | Pubchem Assay |
| PRRID_0276 | CL087 Click for more detail | NA | COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3 | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58681.fasta | P58681 | 1050 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0276 | CL087 Click for more detail | NA | COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3 | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58681.fasta | P58681 | 1050 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0277 | CL097 Click for more detail | NA | CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58682.fasta | P58682 | 1032 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0277 | CL097 Click for more detail | NA | CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58682.fasta | P58682 | 1032 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0278 | CpG ODN Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Salmo salar L. | Spleen and head kidney | NA | NA | NA | NA | It resulted into viral recognition, resulting in an enhanced innate immune response. | NA | 18602433 | 2008 | NA |
| PRRID_0278 | CpG ODN Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Salmo salar L. | Spleen and head kidney | NA | NA | NA | NA | It resulted into viral recognition, resulting in an enhanced innate immune response. | NA | 18602433 | 2008 | NA |
| PRRID_0279 | CpG2006 Click for more detail | NA | 5’-tcgtcgttttgtcgttttgtcgtt-3’ | 24 | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | Q9NR96.fasta | Q9NR96 | 1032 | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | Pubchem Assay |
| PRRID_0279 | CpG2006 Click for more detail | NA | 5’-tcgtcgttttgtcgttttgtcgtt-3’ | 24 | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | Q9NR96.fasta | Q9NR96 | 1032 | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | Pubchem Assay |
| PRRID_0281 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | initiate intracellular signaling cascades that may lead to host inflammation. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | basal epithelial layer. | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | immunohistochemistry | 18793367 | 2008 | Pubchem Assay |
| PRRID_0281 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | initiate intracellular signaling cascades that may lead to host inflammation. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | basal epithelial layer. | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | immunohistochemistry | 18793367 | 2008 | Pubchem Assay |
| PRRID_0288 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0288 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0289 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0289 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0296 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0296 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |