Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0240 | CpG-ODNs Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0240 | CpG-ODNs Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0245 | IC31 Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0245 | IC31 Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0246 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | NA | O60603.fasta | O60603 | 784 | NA | NA | 16861291 | 2006 | Pubchem Assay |
| PRRID_0246 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | NA | O60603.fasta | O60603 | 784 | NA | NA | 16861291 | 2006 | Pubchem Assay |
| PRRID_0247 | MPL (Monophosphoryl-lipid A/trehalose dicorynomycolate (“Ribi” adjuvant)) Click for more detail | lipid A mimetic (others) | CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OP(=O)(O)O)OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Lipid | Synthetic | Immunostimulant | Toll-like receptor 4+unknown | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 17185603 | 2006 | Pubchem Assay |
| PRRID_0247 | MPL (Monophosphoryl-lipid A/trehalose dicorynomycolate (“Ribi” adjuvant)) Click for more detail | lipid A mimetic (others) | CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OP(=O)(O)O)OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Lipid | Synthetic | Immunostimulant | Toll-like receptor 4+unknown | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 17185603 | 2006 | Pubchem Assay |
| PRRID_0248 | Poly (I:C)-LANAC Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Adjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Spleen and lung cells | NA | Q99MB1.fasta | Q99MB1 | 905 | TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags. | ELISA | 16751377 | 2006 | Pubchem Assay |
| PRRID_0248 | Poly (I:C)-LANAC Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | Adjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Spleen and lung cells | NA | Q99MB1.fasta | Q99MB1 | 905 | TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags. | ELISA | 16751377 | 2006 | Pubchem Assay |
| PRRID_0249 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0249 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 mice | spleen cells | NA | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | ELISPOT | 16678312 | 2006 | Pubchem Assay |
| PRRID_0250 | Small Heat Shock Protein B8 (HSP22) Click for more detail | Host (Endogenous) (others) | MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGESSFNNELPQDSQEVTCT | 496 | Protein | Natural | It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Synovial tissue | NA | O00206.fasta | O00206 | 839 | It leads to the activationa and maturation of the dendritic cells | Cyokine assay | 16709864 | 2006 | Pubchem Assay |
| PRRID_0250 | Small Heat Shock Protein B8 (HSP22) Click for more detail | Host (Endogenous) (others) | MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGESSFNNELPQDSQEVTCT | 496 | Protein | Natural | It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Synovial tissue | NA | O00206.fasta | O00206 | 839 | It leads to the activationa and maturation of the dendritic cells | Cyokine assay | 16709864 | 2006 | Pubchem Assay |
| PRRID_0251 | dipalmitoylated proteins Click for more detail | NA | NA | NA | Protein | Natural | triggers immune responses | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 17353199 | 2007 | NA |
| PRRID_0251 | dipalmitoylated proteins Click for more detail | NA | NA | NA | Protein | Natural | triggers immune responses | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 17353199 | 2007 | NA |
| PRRID_0252 | dsDNA Click for more detail | Adenovirus(virus) | NA | NA | Nucleic Acid | Natural | Adenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Plasmacytoid dendritic cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | This leads to the inflammatory response. | ELISA | 17229689 | 2007 | Pubchem Assay |
| PRRID_0252 | dsDNA Click for more detail | Adenovirus(virus) | NA | NA | Nucleic Acid | Natural | Adenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Plasmacytoid dendritic cells | NA | Q9NR96.fasta | Q9NR96 | 1032 | This leads to the inflammatory response. | ELISA | 17229689 | 2007 | Pubchem Assay |
| PRRID_0253 | extra domain A of fibronectin (FN-EDA) Click for more detail | Endogenous (others) | NA | NA | Protein | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 17575266 | 2007 | NA |
| PRRID_0253 | extra domain A of fibronectin (FN-EDA) Click for more detail | Endogenous (others) | NA | NA | Protein | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 17575266 | 2007 | NA |
| PRRID_0254 | Lipopolysaccharide (LPS) Click for more detail | enterobacterial bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0254 | Lipopolysaccharide (LPS) Click for more detail | enterobacterial bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0255 | Lipopolysaccharide (LPS) Click for more detail | E.coli strain O111:B4(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0255 | Lipopolysaccharide (LPS) Click for more detail | E.coli strain O111:B4(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0256 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0256 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a strong response from normal animal immune systems | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0257 | Lipoprotein Click for more detail | Gram-negative and Gram-positive bacteria | NA | NA | Lipoprotein | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0257 | Lipoprotein Click for more detail | Gram-negative and Gram-positive bacteria | NA | NA | Lipoprotein | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 17353199 | 2007 | Pubchem Assay |
| PRRID_0258 | Lipoprotein Click for more detail | Bacteria | NA | NA | Lipoprotein | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0258 | Lipoprotein Click for more detail | Bacteria | NA | NA | Lipoprotein | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0259 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0259 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0260 | N-ALP1 Click for more detail | Mycoplasma pneumoniae (Bacteria) | NA | NA | Lipoprotein | Natural | It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha). | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | human kidney cell line, 293T | NA | NA | NA | NA | It has the role in immuno inflammation. | Transfection and luciferase assay | 17433078 | 2007 | NA |
| PRRID_0260 | N-ALP1 Click for more detail | Mycoplasma pneumoniae (Bacteria) | NA | NA | Lipoprotein | Natural | It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha). | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | human kidney cell line, 293T | NA | NA | NA | NA | It has the role in immuno inflammation. | Transfection and luciferase assay | 17433078 | 2007 | NA |
| PRRID_0261 | N-ALP2 Click for more detail | Mycoplasma pneumoniae (Bacteria) | NA | NA | Lipoprotein | Natural | It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha). | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | human kidney cell line, 293T | NA | NA | NA | NA | It has the role in immuno inflammation. | Transfection and luciferase assay | 17433078 | 2007 | NA |
| PRRID_0261 | N-ALP2 Click for more detail | Mycoplasma pneumoniae (Bacteria) | NA | NA | Lipoprotein | Natural | It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha). | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | human kidney cell line, 293T | NA | NA | NA | NA | It has the role in immuno inflammation. | Transfection and luciferase assay | 17433078 | 2007 | NA |
| PRRID_0263 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | elicit innate immune response | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | macrophages and dendritic cells | NA | O15455.fasta | O15455 | 904 | Induces pro-inflammatory cytokine response | NA | 17573354 | 2007 | Pubchem Assay |
| PRRID_0263 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | elicit innate immune response | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | macrophages and dendritic cells | NA | O15455.fasta | O15455 | 904 | Induces pro-inflammatory cytokine response | NA | 17573354 | 2007 | Pubchem Assay |
| PRRID_0264 | Tripalmitoylated proteins Click for more detail | NA | NA | NA | Carbohydrate | Natural | triggers immune responses | Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1 | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 17353199 | 2007 | NA |
| PRRID_0264 | Tripalmitoylated proteins Click for more detail | NA | NA | NA | Carbohydrate | Natural | triggers immune responses | Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1 | Toll-like receptor (TLR) | Mice | Peripheral blood mononuclear cells (PBMC) | cytoplasmic leucine rich repeat (LRR) | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 17353199 | 2007 | NA |
| PRRID_0265 | Unmethylated CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0265 | Unmethylated CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | BALB/c and C57BL/6 mice | Spleen cells | Toll- IL-1R domain | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 17404301 | 2007 | Pubchem Assay |
| PRRID_0266 | 3M-003 Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | NA | NA | NA | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | NA |
| PRRID_0266 | 3M-003 Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | NA | NA | NA | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | NA |
| PRRID_0267 | 3M002 (CL075) Click for more detail | NA | CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58682.fasta | P58682 | 1032 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0267 | 3M002 (CL075) Click for more detail | NA | CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58682.fasta | P58682 | 1032 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0268 | 852A Click for more detail | NA | CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O | NA | Nucleic Acid | Synthetic | It has stimulated the production of interferon-‚ç∫ (IFN-‚ç∫), IFN-inducible protein-10 (IP-10), interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),IL-12p70, IL-18, and IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood mononuclear cells (PBMC) | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It has inhibited the proliferation of tumor cell lines Hs294T and 769-P. | ELISA | 18439103 | 2008 | Pubchem Assay |
| PRRID_0268 | 852A Click for more detail | NA | CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O | NA | Nucleic Acid | Synthetic | It has stimulated the production of interferon-‚ç∫ (IFN-‚ç∫), IFN-inducible protein-10 (IP-10), interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),IL-12p70, IL-18, and IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood mononuclear cells (PBMC) | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It has inhibited the proliferation of tumor cell lines Hs294T and 769-P. | ELISA | 18439103 | 2008 | Pubchem Assay |
| PRRID_0269 | 852A Click for more detail | NA | CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O | NA | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | Pubchem Assay |
| PRRID_0269 | 852A Click for more detail | NA | CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O | NA | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | Pubchem Assay |
| PRRID_0270 | Acute-phase serum amyloid A (SAA) Click for more detail | Human (others) | MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY | 122 | Protein | Natural | TLR2 responded to SAA with potent activation of NF-κB, moreover it increased phosphorylation of MAP kinases and accelerated IκBα degradation. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Macrophages | Ectodomain | Q9QUN7.fasta | Q9QUN7 | 784 | It is resoonsible for the immuno-inflammation in the host cell. | Solid-phase binding assay and NF-κB luciferase report assay | 18566366 | 2008 | Pubchem Assay |
| PRRID_0270 | Acute-phase serum amyloid A (SAA) Click for more detail | Human (others) | MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY | 122 | Protein | Natural | TLR2 responded to SAA with potent activation of NF-κB, moreover it increased phosphorylation of MAP kinases and accelerated IκBα degradation. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Macrophages | Ectodomain | Q9QUN7.fasta | Q9QUN7 | 784 | It is resoonsible for the immuno-inflammation in the host cell. | Solid-phase binding assay and NF-κB luciferase report assay | 18566366 | 2008 | Pubchem Assay |
| PRRID_0271 | AM3 Click for more detail | Immunomodulatory drug (others) | NA | NA | Glycoconjugate | Synthetic | AM3 induces NF-kB activation, IkB-a degradation and MAPK phosphorylationand enhanced the expression of CD54, CD83, CD86, HLA-DR, chemokines and chemokine receptors, interleukin (IL)-12p70 and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytederived Dendritic cells (MDDCs) | LRR | O00206.fasta | O00206 | 839 | AM3 induces human MDDC maturation, enhance and activates the T-cell proliferation and promotes MDDC maturation in patients with chronic HCV infection. | ELISA | 18414382 | 2008 | Pubchem Assay |
| PRRID_0271 | AM3 Click for more detail | Immunomodulatory drug (others) | NA | NA | Glycoconjugate | Synthetic | AM3 induces NF-kB activation, IkB-a degradation and MAPK phosphorylationand enhanced the expression of CD54, CD83, CD86, HLA-DR, chemokines and chemokine receptors, interleukin (IL)-12p70 and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytederived Dendritic cells (MDDCs) | LRR | O00206.fasta | O00206 | 839 | AM3 induces human MDDC maturation, enhance and activates the T-cell proliferation and promotes MDDC maturation in patients with chronic HCV infection. | ELISA | 18414382 | 2008 | Pubchem Assay |
| PRRID_0272 | Aminoalkyl Glucosaminide Phosphate (AGP) Click for more detail | NA | NA | NA | Lipid | Synthetic | AGPs boost the innate immune response to infection with F. novicida. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macropahges and Dendritic cells | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It provides Protectection to Mice from Pneumonic Tularemia. | ELISA | 18490759 | 2008 | Pubchem Assay |
| PRRID_0272 | Aminoalkyl Glucosaminide Phosphate (AGP) Click for more detail | NA | NA | NA | Lipid | Synthetic | AGPs boost the innate immune response to infection with F. novicida. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macropahges and Dendritic cells | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It provides Protectection to Mice from Pneumonic Tularemia. | ELISA | 18490759 | 2008 | Pubchem Assay |
| PRRID_0276 | CL087 Click for more detail | NA | COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3 | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58681.fasta | P58681 | 1050 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0276 | CL087 Click for more detail | NA | COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3 | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58681.fasta | P58681 | 1050 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0277 | CL097 Click for more detail | NA | CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58682.fasta | P58682 | 1032 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0277 | CL097 Click for more detail | NA | CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58682.fasta | P58682 | 1032 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0278 | CpG ODN Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Salmo salar L. | Spleen and head kidney | NA | NA | NA | NA | It resulted into viral recognition, resulting in an enhanced innate immune response. | NA | 18602433 | 2008 | NA |
| PRRID_0278 | CpG ODN Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Salmo salar L. | Spleen and head kidney | NA | NA | NA | NA | It resulted into viral recognition, resulting in an enhanced innate immune response. | NA | 18602433 | 2008 | NA |
| PRRID_0279 | CpG2006 Click for more detail | NA | 5’-tcgtcgttttgtcgttttgtcgtt-3’ | 24 | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | Q9NR96.fasta | Q9NR96 | 1032 | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | Pubchem Assay |
| PRRID_0279 | CpG2006 Click for more detail | NA | 5’-tcgtcgttttgtcgttttgtcgtt-3’ | 24 | Nucleic Acid | Synthetic | Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | B cells and pDC | NA | Q9NR96.fasta | Q9NR96 | 1032 | It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival. | ELISA | 18652679 | 2008 | Pubchem Assay |
| PRRID_0281 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | initiate intracellular signaling cascades that may lead to host inflammation. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | basal epithelial layer. | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | immunohistochemistry | 18793367 | 2008 | Pubchem Assay |
| PRRID_0281 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | initiate intracellular signaling cascades that may lead to host inflammation. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | basal epithelial layer. | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | NA | immunohistochemistry | 18793367 | 2008 | Pubchem Assay |
| PRRID_0284 | Flagellin Click for more detail | Salmonella typhimurium (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | The binding leads to the secretion of cytokines, such as KC, IP-10, and MCP-1. | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | nonhemopoietic (radioresistant) cells | LRR | Q9JLF7.fasta | Q9JLF7 | 859 | It has a immunostimulatory role | ELISA | 18490717 | 2008 | Pubchem Assay |
| PRRID_0284 | Flagellin Click for more detail | Salmonella typhimurium (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | The binding leads to the secretion of cytokines, such as KC, IP-10, and MCP-1. | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | nonhemopoietic (radioresistant) cells | LRR | Q9JLF7.fasta | Q9JLF7 | 859 | It has a immunostimulatory role | ELISA | 18490717 | 2008 | Pubchem Assay |
| PRRID_0285 | Flagellin Click for more detail | Salmonella typhimurium (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | The binding leads to the secretion of cytokines, such as TNF-‚ç∫, IL-12, and IL-6.‚ç∫ | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | hemopoietic (radiosensitive) cells | LRR | Q9JLF7.fasta | Q9JLF7 | 859 | It has a immunostimulatory role | ELISA | 18490717 | 2008 | Pubchem Assay |
| PRRID_0285 | Flagellin Click for more detail | Salmonella typhimurium (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | The binding leads to the secretion of cytokines, such as TNF-‚ç∫, IL-12, and IL-6.‚ç∫ | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | hemopoietic (radiosensitive) cells | LRR | Q9JLF7.fasta | Q9JLF7 | 859 | It has a immunostimulatory role | ELISA | 18490717 | 2008 | Pubchem Assay |
| PRRID_0286 | Flagellin Click for more detail | Pseudomonas aeruginosa (Bacteria) | GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP | 434 | Protein | Natural | Stimulation demonstrated that TLR signaling appears to mediate the excessive cytokine production occurring in CF. | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | CF Patients | Airway epithelial cells and primary PBMCs | LRR | O60602.fasta | O60602 | 858 | Stimultion of TLR5 leads to the excessive inflammation which leads to the damaginf effect. | ELISA | 18490781 | 2008 | Pubchem Assay |
| PRRID_0286 | Flagellin Click for more detail | Pseudomonas aeruginosa (Bacteria) | GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP | 434 | Protein | Natural | Stimulation demonstrated that TLR signaling appears to mediate the excessive cytokine production occurring in CF. | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | CF Patients | Airway epithelial cells and primary PBMCs | LRR | O60602.fasta | O60602 | 858 | Stimultion of TLR5 leads to the excessive inflammation which leads to the damaginf effect. | ELISA | 18490781 | 2008 | Pubchem Assay |
| PRRID_0287 | FTT1103 Click for more detail | Mycoplasma pneumoniae (Bacteria) | NA | NA | Lipoprotein | Natural | Immunostimulant | Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1 | Toll-like receptor (TLR) | Human | NA | NA | NA | NA | NA | capable of stimulating a proinflammatory response and the cellular receptors they trigger | NA | 18079113 | 2008 | NA |
| PRRID_0287 | FTT1103 Click for more detail | Mycoplasma pneumoniae (Bacteria) | NA | NA | Lipoprotein | Natural | Immunostimulant | Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1 | Toll-like receptor (TLR) | Human | NA | NA | NA | NA | NA | capable of stimulating a proinflammatory response and the cellular receptors they trigger | NA | 18079113 | 2008 | NA |
| PRRID_0288 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0288 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0289 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0289 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0290 | German Cockroach frass Click for more detail | German Cockroach (others) | NA | NA | Allergen | Natural | It induced NF-κB translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-⍺ and IL-6. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Neutrophils | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | It is responisble for the immune response against the allergen having origin as German Cockroach frass. | ELISA | 18424755 | 2008 | Pubchem Assay |
| PRRID_0290 | German Cockroach frass Click for more detail | German Cockroach (others) | NA | NA | Allergen | Natural | It induced NF-κB translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-⍺ and IL-6. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Neutrophils | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | It is responisble for the immune response against the allergen having origin as German Cockroach frass. | ELISA | 18424755 | 2008 | Pubchem Assay |
| PRRID_0291 | German Cockroach frass Click for more detail | German Cockroach (others) | NA | NA | Allergen | Natural | It induced NF-κB translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-⍺ and IL-8. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Primary human neutrophils | LRR | O60603.fasta | O60603 | 784 | It is responisble for the immune response against the allergen having origin as German Cockroach frass. | ELISA | 18424755 | 2008 | Pubchem Assay |
| PRRID_0291 | German Cockroach frass Click for more detail | German Cockroach (others) | NA | NA | Allergen | Natural | It induced NF-κB translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-⍺ and IL-8. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Primary human neutrophils | LRR | O60603.fasta | O60603 | 784 | It is responisble for the immune response against the allergen having origin as German Cockroach frass. | ELISA | 18424755 | 2008 | Pubchem Assay |
| PRRID_0293 | Hantaan virus (HTNV) Click for more detail | Hantaan virus (HTNV) (Virus) | NA | NA | Whole organism | Natural | HTNV infection induces IFN-β, IL-6 and TNF-α expression. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Endothelial vein cells (EVC-304) | LRR | O00206.fasta | O00206 | 839 | TLR4 is a potential factor in HFRS pathogenesis. | ELISA | 18707748 | 2008 | Pubchem Assay |
| PRRID_0293 | Hantaan virus (HTNV) Click for more detail | Hantaan virus (HTNV) (Virus) | NA | NA | Whole organism | Natural | HTNV infection induces IFN-β, IL-6 and TNF-α expression. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Endothelial vein cells (EVC-304) | LRR | O00206.fasta | O00206 | 839 | TLR4 is a potential factor in HFRS pathogenesis. | ELISA | 18707748 | 2008 | Pubchem Assay |
| PRRID_0294 | Hyaluronan Click for more detail | Sperm-secreted hyaluronidase (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Hyaluronan fragments or hyaluronidase activates the NFκB pathway and induced Il6, Ccl4 and Ccl5 mRNA expression. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Ovulated Cumulus-Oocyte Complexes(COCs) | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization. | Sperm accumulation assay | 18434414 | 2008 | Pubchem Assay |
| PRRID_0294 | Hyaluronan Click for more detail | Sperm-secreted hyaluronidase (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Hyaluronan fragments or hyaluronidase activates the NFκB pathway and induced Il6, Ccl4 and Ccl5 mRNA expression. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Ovulated Cumulus-Oocyte Complexes(COCs) | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization. | Sperm accumulation assay | 18434414 | 2008 | Pubchem Assay |
| PRRID_0295 | Hyaluronan Click for more detail | Sperm-secreted hyaluronidase (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Hyaluronan fragments or hyaluronidase activates the NFκB pathway and induced Il6, Ccl4 and Ccl5 mRNA expression. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Ovulated Cumulus-Oocyte Complexes(COCs) | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization. | Sperm accumulation assay | 18434414 | 2008 | Pubchem Assay |
| PRRID_0295 | Hyaluronan Click for more detail | Sperm-secreted hyaluronidase (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Hyaluronan fragments or hyaluronidase activates the NFκB pathway and induced Il6, Ccl4 and Ccl5 mRNA expression. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Ovulated Cumulus-Oocyte Complexes(COCs) | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization. | Sperm accumulation assay | 18434414 | 2008 | Pubchem Assay |
| PRRID_0296 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0296 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0297 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0297 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Porcine | Lymph node tissue | LRR | NA | NA | NA | It has a immunostimulatory role | NF- | 18439678 | 2008 | NA |
| PRRID_0298 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | imiquimod leads to decreased tyrosinase and MITF expression and is accompanied by decreased pigmentation. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Melanocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | It inhibits Melanogenesis and Proliferation of Human Melanocytes. | NA | 18596825 | 2008 | Pubchem Assay |
| PRRID_0298 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | imiquimod leads to decreased tyrosinase and MITF expression and is accompanied by decreased pigmentation. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Melanocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | It inhibits Melanogenesis and Proliferation of Human Melanocytes. | NA | 18596825 | 2008 | Pubchem Assay |
| PRRID_0299 | Imiquimod (R837) Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58681.fasta | P58681 | 1050 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0299 | Imiquimod (R837) Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Newborn Mice | Astrocytes and microglia | LRR | P58681.fasta | P58681 | 1050 | It induces a neuroinflammatory response in CNS. | Cytokines assay | 18490763 | 2008 | Pubchem Assay |
| PRRID_0301 | Lipid A Click for more detail | Burkholderia pseudomallei(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Natural | Stimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | HEK293 cells | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It has a immunostimulatory role | ELISA | 18691413 | 2008 | Pubchem Assay |
| PRRID_0301 | Lipid A Click for more detail | Burkholderia pseudomallei(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Natural | Stimulation via LPS leads to the production of TNF-α, MIP-2, and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | HEK293 cells | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It has a immunostimulatory role | ELISA | 18691413 | 2008 | Pubchem Assay |
| PRRID_0302 | Lipid A Click for more detail | Burkholderia pseudomallei(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Natural | Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-α, MIP-2, and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 cells | LRR | O00206.fasta | O00206 | 839 | It has a immunostimulatory role | ELISA | 18691413 | 2008 | Pubchem Assay |
| PRRID_0302 | Lipid A Click for more detail | Burkholderia pseudomallei(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Natural | Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-α, MIP-2, and IL-10. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 cells | LRR | O00206.fasta | O00206 | 839 | It has a immunostimulatory role | ELISA | 18691413 | 2008 | Pubchem Assay |