Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0240	CpG-ODNs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0240	CpG-ODNs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0245	IC31 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0245	IC31 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0246	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	NA	O60603.fasta	O60603	784	NA	NA	16861291	2006	Pubchem Assay
PRRID_0246	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	NA	O60603.fasta	O60603	784	NA	NA	16861291	2006	Pubchem Assay
PRRID_0247	MPL (Monophosphoryl-lipid A/trehalose dicorynomycolate (‚Äö√Ñ√∫Ribi‚Äö√Ñ√π adjuvant)) Click for more detail	lipid A mimetic (others)	CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OP(=O)(O)O)OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Lipid	Synthetic	Immunostimulant	Toll-like receptor 4+unknown	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	NA	NA	17185603	2006	Pubchem Assay
PRRID_0247	MPL (Monophosphoryl-lipid A/trehalose dicorynomycolate (‚Äö√Ñ√∫Ribi‚Äö√Ñ√π adjuvant)) Click for more detail	lipid A mimetic (others)	CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)OP(=O)(O)O)OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Lipid	Synthetic	Immunostimulant	Toll-like receptor 4+unknown	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUK6.fasta	Q9QUK6	835	NA	NA	17185603	2006	Pubchem Assay
PRRID_0248	Poly (I:C)-LANAC Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Adjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Spleen and lung cells	NA	Q99MB1.fasta	Q99MB1	905	TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags.	ELISA	16751377	2006	Pubchem Assay
PRRID_0248	Poly (I:C)-LANAC Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	Adjuvant activity of LANAC is dependent on signaling via a MyD88-dependent pathway and elicits strong CD8+ and CD4+ T cell responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Spleen and lung cells	NA	Q99MB1.fasta	Q99MB1	905	TLR agonists combined with cationic liposomes to produce uniquely effective vaccine adjuvants capable of eliciting strong T cell responses against protein and peptide Ags.	ELISA	16751377	2006	Pubchem Assay
PRRID_0249	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0249	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	C57BL/6 mice	spleen cells	NA	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	ELISPOT	16678312	2006	Pubchem Assay
PRRID_0250	Small Heat Shock Protein B8 (HSP22) Click for more detail	Host (Endogenous) (others)	MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGESSFNNELPQDSQEVTCT	496	Protein	Natural	It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Synovial tissue	NA	O00206.fasta	O00206	839	It leads to the activationa and maturation of the dendritic cells	Cyokine assay	16709864	2006	Pubchem Assay
PRRID_0250	Small Heat Shock Protein B8 (HSP22) Click for more detail	Host (Endogenous) (others)	MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGESSFNNELPQDSQEVTCT	496	Protein	Natural	It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Synovial tissue	NA	O00206.fasta	O00206	839	It leads to the activationa and maturation of the dendritic cells	Cyokine assay	16709864	2006	Pubchem Assay
PRRID_0251	dipalmitoylated proteins Click for more detail	NA	NA	NA	Protein	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	17353199	2007	NA
PRRID_0251	dipalmitoylated proteins Click for more detail	NA	NA	NA	Protein	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	17353199	2007	NA
PRRID_0252	dsDNA Click for more detail	Adenovirus(virus)	NA	NA	Nucleic Acid	Natural	Adenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Plasmacytoid dendritic cells	NA	Q9NR96.fasta	Q9NR96	1032	This leads to the inflammatory response.	ELISA	17229689	2007	Pubchem Assay
PRRID_0252	dsDNA Click for more detail	Adenovirus(virus)	NA	NA	Nucleic Acid	Natural	Adenovirus induces the production of high levels of type I interferons (IFNs),is mediated by TLR9 in a MyD88-dependent manner.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	Plasmacytoid dendritic cells	NA	Q9NR96.fasta	Q9NR96	1032	This leads to the inflammatory response.	ELISA	17229689	2007	Pubchem Assay
PRRID_0253	extra domain A of fibronectin (FN-EDA) Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	17575266	2007	NA
PRRID_0253	extra domain A of fibronectin (FN-EDA) Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	17575266	2007	NA
PRRID_0254	Lipopolysaccharide (LPS) Click for more detail	enterobacterial bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	17353199	2007	Pubchem Assay
PRRID_0254	Lipopolysaccharide (LPS) Click for more detail	enterobacterial bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	17353199	2007	Pubchem Assay
PRRID_0255	Lipopolysaccharide (LPS) Click for more detail	E.coli strain O111:B4(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	17353199	2007	Pubchem Assay
PRRID_0255	Lipopolysaccharide (LPS) Click for more detail	E.coli strain O111:B4(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	17353199	2007	Pubchem Assay
PRRID_0256	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	17404301	2007	Pubchem Assay
PRRID_0256	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal¬†immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	17404301	2007	Pubchem Assay
PRRID_0257	Lipoprotein Click for more detail	Gram-negative and Gram-positive bacteria	NA	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	ELISA	17353199	2007	Pubchem Assay
PRRID_0257	Lipoprotein Click for more detail	Gram-negative and Gram-positive bacteria	NA	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	ELISA	17353199	2007	Pubchem Assay
PRRID_0258	Lipoprotein Click for more detail	Bacteria	NA	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	17404301	2007	Pubchem Assay
PRRID_0258	Lipoprotein Click for more detail	Bacteria	NA	NA	Lipoprotein	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	17404301	2007	Pubchem Assay
PRRID_0259	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	17404301	2007	Pubchem Assay
PRRID_0259	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9QUN7.fasta	Q9QUN7	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	17404301	2007	Pubchem Assay
PRRID_0260	N-ALP1 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha).	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	human kidney cell line, 293T	NA	NA	NA	NA	It has the role in immuno inflammation.	Transfection and luciferase assay	17433078	2007	NA
PRRID_0260	N-ALP1 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha).	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	human kidney cell line, 293T	NA	NA	NA	NA	It has the role in immuno inflammation.	Transfection and luciferase assay	17433078	2007	NA
PRRID_0261	N-ALP2 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha).	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	human kidney cell line, 293T	NA	NA	NA	NA	It has the role in immuno inflammation.	Transfection and luciferase assay	17433078	2007	NA
PRRID_0261	N-ALP2 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	It induces the activation of NF-kappaB and induces the expression levels of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha).	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	human kidney cell line, 293T	NA	NA	NA	NA	It has the role in immuno inflammation.	Transfection and luciferase assay	17433078	2007	NA
PRRID_0263	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	macrophages and dendritic cells	NA	O15455.fasta	O15455	904	Induces pro-inflammatory cytokine response	NA	17573354	2007	Pubchem Assay
PRRID_0263	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	elicit innate immune response	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	macrophages and dendritic cells	NA	O15455.fasta	O15455	904	Induces pro-inflammatory cytokine response	NA	17573354	2007	Pubchem Assay
PRRID_0264	Tripalmitoylated proteins Click for more detail	NA	NA	NA	Carbohydrate	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	17353199	2007	NA
PRRID_0264	Tripalmitoylated proteins Click for more detail	NA	NA	NA	Carbohydrate	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Mice	Peripheral blood mononuclear cells (PBMC)	cytoplasmic leucine rich repeat (LRR)	NA	NA	NA	TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.	ELISA	17353199	2007	NA
PRRID_0265	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	17404301	2007	Pubchem Assay
PRRID_0265	Unmethylated CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	BALB/c and C57BL/6 mice	Spleen cells	Toll- IL-1R domain	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	17404301	2007	Pubchem Assay
PRRID_0266	3M-003 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	NA	NA	NA	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	NA
PRRID_0266	3M-003 Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	NA	NA	NA	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	NA
PRRID_0267	3M002 (CL075) Click for more detail	NA	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58682.fasta	P58682	1032	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0267	3M002 (CL075) Click for more detail	NA	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58682.fasta	P58682	1032	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0268	852A Click for more detail	NA	CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O	NA	Nucleic Acid	Synthetic	It has stimulated the production of interferon-‚ç∫ (IFN-‚ç∫), IFN-inducible protein-10 (IP-10), interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),IL-12p70, IL-18, and IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood mononuclear cells (PBMC)	LRR	Q9NYK1.fasta	Q9NYK1	1049	It has inhibited the proliferation of tumor cell lines Hs294T and 769-P.	ELISA	18439103	2008	Pubchem Assay
PRRID_0268	852A Click for more detail	NA	CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O	NA	Nucleic Acid	Synthetic	It has stimulated the production of interferon-‚ç∫ (IFN-‚ç∫), IFN-inducible protein-10 (IP-10), interleukin-1 receptor antagonist (IL-1Ra), monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL),IL-12p70, IL-18, and IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood mononuclear cells (PBMC)	LRR	Q9NYK1.fasta	Q9NYK1	1049	It has inhibited the proliferation of tumor cell lines Hs294T and 769-P.	ELISA	18439103	2008	Pubchem Assay
PRRID_0269	852A Click for more detail	NA	CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O	NA	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	Q9NYK1.fasta	Q9NYK1	1049	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	Pubchem Assay
PRRID_0269	852A Click for more detail	NA	CCCC=CC=CC(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(C1CCC(CC1)O)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(C2CCC(CC2)O)C(=O)NC(C3CCC(CC3)O)C(=O)NC(C(C)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCN)C(=O)NC(C5CCC(CC5)O)C(=O)NC(C(C)O)C(=O)NC(C6CCC(CC6)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C7CCC(C(C7)Cl)O)C(=O)O	NA	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	Q9NYK1.fasta	Q9NYK1	1049	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	Pubchem Assay
PRRID_0270	Acute-phase serum amyloid A (SAA) Click for more detail	Human (others)	MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY	122	Protein	Natural	TLR2 responded to SAA with potent activation of NF-Œ∫B, moreover it increased phosphorylation of MAP kinases and accelerated IŒ∫BŒ± degradation.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	Ectodomain	Q9QUN7.fasta	Q9QUN7	784	It is resoonsible for the immuno-inflammation in the host cell.	Solid-phase binding assay and NF-Œ∫B luciferase report assay	18566366	2008	Pubchem Assay
PRRID_0270	Acute-phase serum amyloid A (SAA) Click for more detail	Human (others)	MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY	122	Protein	Natural	TLR2 responded to SAA with potent activation of NF-Œ∫B, moreover it increased phosphorylation of MAP kinases and accelerated IŒ∫BŒ± degradation.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macrophages	Ectodomain	Q9QUN7.fasta	Q9QUN7	784	It is resoonsible for the immuno-inflammation in the host cell.	Solid-phase binding assay and NF-Œ∫B luciferase report assay	18566366	2008	Pubchem Assay
PRRID_0271	AM3 Click for more detail	Immunomodulatory drug (others)	NA	NA	Glycoconjugate	Synthetic	AM3 induces NF-kB activation, IkB-a degradation and MAPK phosphorylationand enhanced the expression of CD54, CD83, CD86, HLA-DR, chemokines and chemokine receptors, interleukin (IL)-12p70 and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytederived Dendritic cells (MDDCs)	LRR	O00206.fasta	O00206	839	AM3 induces human MDDC maturation, enhance and activates the T-cell proliferation and promotes MDDC maturation in patients with chronic HCV infection.	ELISA	18414382	2008	Pubchem Assay
PRRID_0271	AM3 Click for more detail	Immunomodulatory drug (others)	NA	NA	Glycoconjugate	Synthetic	AM3 induces NF-kB activation, IkB-a degradation and MAPK phosphorylationand enhanced the expression of CD54, CD83, CD86, HLA-DR, chemokines and chemokine receptors, interleukin (IL)-12p70 and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytederived Dendritic cells (MDDCs)	LRR	O00206.fasta	O00206	839	AM3 induces human MDDC maturation, enhance and activates the T-cell proliferation and promotes MDDC maturation in patients with chronic HCV infection.	ELISA	18414382	2008	Pubchem Assay
PRRID_0272	Aminoalkyl Glucosaminide Phosphate (AGP) Click for more detail	NA	NA	NA	Lipid	Synthetic	AGPs boost the innate immune response to infection with F. novicida.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macropahges and Dendritic cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It provides Protectection to Mice from Pneumonic Tularemia.	ELISA	18490759	2008	Pubchem Assay
PRRID_0272	Aminoalkyl Glucosaminide Phosphate (AGP) Click for more detail	NA	NA	NA	Lipid	Synthetic	AGPs boost the innate immune response to infection with F. novicida.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macropahges and Dendritic cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It provides Protectection to Mice from Pneumonic Tularemia.	ELISA	18490759	2008	Pubchem Assay
PRRID_0276	CL087 Click for more detail	NA	COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0276	CL087 Click for more detail	NA	COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0277	CL097 Click for more detail	NA	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58682.fasta	P58682	1032	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0277	CL097 Click for more detail	NA	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58682.fasta	P58682	1032	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0278	CpG ODN Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Salmo salar L.	Spleen and head kidney	NA	NA	NA	NA	It resulted into viral recognition, resulting in an enhanced innate immune response.	NA	18602433	2008	NA
PRRID_0278	CpG ODN Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	It leads to up-regulation of the genes interferon (IFN)-alpha1/alpha2, Mx, CXCL10, IL-1beta, IFN-gamma and CD83.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Salmo salar L.	Spleen and head kidney	NA	NA	NA	NA	It resulted into viral recognition, resulting in an enhanced innate immune response.	NA	18602433	2008	NA
PRRID_0279	CpG2006 Click for more detail	NA	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	Q9NR96.fasta	Q9NR96	1032	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	Pubchem Assay
PRRID_0279	CpG2006 Click for more detail	NA	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	Stimulation leads to the increased gene expression of cytokines and chemokines such as, IL-6, MIP1 alpha, MIP1 beta, TNF alpha, and LTA.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	B cells and pDC	NA	Q9NR96.fasta	Q9NR96	1032	It induces changes in gene expression and protein production that effect B cell function such as, Cell Migration, Signal Transduction, Proliferation, Differentiation and Survival.	ELISA	18652679	2008	Pubchem Assay
PRRID_0281	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	basal epithelial layer.	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0281	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	initiate intracellular signaling cascades that may lead to host inflammation.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	basal epithelial layer.	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	immunohistochemistry	18793367	2008	Pubchem Assay
PRRID_0284	Flagellin Click for more detail	Salmonella typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	The binding leads to the secretion of cytokines, such as KC, IP-10, and MCP-1.	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	nonhemopoietic (radioresistant) cells	LRR	Q9JLF7.fasta	Q9JLF7	859	It has a immunostimulatory role	ELISA	18490717	2008	Pubchem Assay
PRRID_0284	Flagellin Click for more detail	Salmonella typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	The binding leads to the secretion of cytokines, such as KC, IP-10, and MCP-1.	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	nonhemopoietic (radioresistant) cells	LRR	Q9JLF7.fasta	Q9JLF7	859	It has a immunostimulatory role	ELISA	18490717	2008	Pubchem Assay
PRRID_0285	Flagellin Click for more detail	Salmonella typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	The binding leads to the secretion of cytokines, such as TNF-‚ç∫, IL-12, and IL-6.‚ç∫	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	hemopoietic (radiosensitive) cells	LRR	Q9JLF7.fasta	Q9JLF7	859	It has a immunostimulatory role	ELISA	18490717	2008	Pubchem Assay
PRRID_0285	Flagellin Click for more detail	Salmonella typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	The binding leads to the secretion of cytokines, such as TNF-‚ç∫, IL-12, and IL-6.‚ç∫	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	hemopoietic (radiosensitive) cells	LRR	Q9JLF7.fasta	Q9JLF7	859	It has a immunostimulatory role	ELISA	18490717	2008	Pubchem Assay
PRRID_0286	Flagellin Click for more detail	Pseudomonas aeruginosa (Bacteria)	GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP	434	Protein	Natural	Stimulation demonstrated that TLR signaling appears to mediate the excessive cytokine production occurring in CF.	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	CF Patients	Airway epithelial cells and primary PBMCs	LRR	O60602.fasta	O60602	858	Stimultion of TLR5 leads to the excessive inflammation which leads to the damaginf effect.	ELISA	18490781	2008	Pubchem Assay
PRRID_0286	Flagellin Click for more detail	Pseudomonas aeruginosa (Bacteria)	GLQIANRLTNQISGLNVATRNADDDISLAQTAEGVLQQATSILQRIRDLALQSANGSNSDVDRAALQKEVAAQQDELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTVVTGYVQLNSPTAYSVSGTGTQASQVFGNASSSQKSSVASVDISTSDGAQNAIAVVDNVLAAIDAQRADLGAVQSRFKSTIDNLTNISENATNARSRIKDTDFAASETSALSNQVLQQAGTAILAQANQLP	434	Protein	Natural	Stimulation demonstrated that TLR signaling appears to mediate the excessive cytokine production occurring in CF.	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	CF Patients	Airway epithelial cells and primary PBMCs	LRR	O60602.fasta	O60602	858	Stimultion of TLR5 leads to the excessive inflammation which leads to the damaginf effect.	ELISA	18490781	2008	Pubchem Assay
PRRID_0287	FTT1103 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	capable of stimulating a proinflammatory response and the cellular receptors they trigger	NA	18079113	2008	NA
PRRID_0287	FTT1103 Click for more detail	Mycoplasma pneumoniae (Bacteria)	NA	NA	Lipoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)/Toll-like receptor (TLR1	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	capable of stimulating a proinflammatory response and the cellular receptors they trigger	NA	18079113	2008	NA
PRRID_0288	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0288	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0289	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0289	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0290	German Cockroach frass Click for more detail	German Cockroach (others)	NA	NA	Allergen	Natural	It induced NF-Œ∫B translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-‚ç∫ and IL-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Neutrophils	LRR	Q9QUN7.fasta	Q9QUN7	784	It is responisble for the immune response against the allergen having origin as German Cockroach frass.	ELISA	18424755	2008	Pubchem Assay
PRRID_0290	German Cockroach frass Click for more detail	German Cockroach (others)	NA	NA	Allergen	Natural	It induced NF-Œ∫B translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-‚ç∫ and IL-6.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Neutrophils	LRR	Q9QUN7.fasta	Q9QUN7	784	It is responisble for the immune response against the allergen having origin as German Cockroach frass.	ELISA	18424755	2008	Pubchem Assay
PRRID_0291	German Cockroach frass Click for more detail	German Cockroach (others)	NA	NA	Allergen	Natural	It induced NF-Œ∫B translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-‚ç∫ and IL-8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Primary human neutrophils	LRR	O60603.fasta	O60603	784	It is responisble for the immune response against the allergen having origin as German Cockroach frass.	ELISA	18424755	2008	Pubchem Assay
PRRID_0291	German Cockroach frass Click for more detail	German Cockroach (others)	NA	NA	Allergen	Natural	It induced NF-Œ∫B translocation and DNA binding, which leads to the secretions of cytokines, such as TNF-‚ç∫ and IL-8.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Primary human neutrophils	LRR	O60603.fasta	O60603	784	It is responisble for the immune response against the allergen having origin as German Cockroach frass.	ELISA	18424755	2008	Pubchem Assay
PRRID_0293	Hantaan virus (HTNV) Click for more detail	Hantaan virus (HTNV) (Virus)	NA	NA	Whole organism	Natural	HTNV infection induces IFN-Œ≤, IL-6 and TNF-Œ± expression.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Endothelial vein cells (EVC-304)	LRR	O00206.fasta	O00206	839	TLR4 is a potential factor in HFRS pathogenesis.	ELISA	18707748	2008	Pubchem Assay
PRRID_0293	Hantaan virus (HTNV) Click for more detail	Hantaan virus (HTNV) (Virus)	NA	NA	Whole organism	Natural	HTNV infection induces IFN-Œ≤, IL-6 and TNF-Œ± expression.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Endothelial vein cells (EVC-304)	LRR	O00206.fasta	O00206	839	TLR4 is a potential factor in HFRS pathogenesis.	ELISA	18707748	2008	Pubchem Assay
PRRID_0294	Hyaluronan Click for more detail	Sperm-secreted hyaluronidase (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Hyaluronan fragments or hyaluronidase activates the NFŒ∫B pathway and induced Il6, Ccl4 and Ccl5 mRNA expression.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Ovulated Cumulus-Oocyte Complexes(COCs)	LRR	Q9QUN7.fasta	Q9QUN7	784	The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization.	Sperm accumulation assay	18434414	2008	Pubchem Assay
PRRID_0294	Hyaluronan Click for more detail	Sperm-secreted hyaluronidase (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Hyaluronan fragments or hyaluronidase activates the NFŒ∫B pathway and induced Il6, Ccl4 and Ccl5 mRNA expression.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Ovulated Cumulus-Oocyte Complexes(COCs)	LRR	Q9QUN7.fasta	Q9QUN7	784	The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization.	Sperm accumulation assay	18434414	2008	Pubchem Assay
PRRID_0295	Hyaluronan Click for more detail	Sperm-secreted hyaluronidase (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Hyaluronan fragments or hyaluronidase activates the NFŒ∫B pathway and induced Il6, Ccl4 and Ccl5 mRNA expression.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Ovulated Cumulus-Oocyte Complexes(COCs)	LRR	Q9QUK6.fasta	Q9QUK6	835	The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization.	Sperm accumulation assay	18434414	2008	Pubchem Assay
PRRID_0295	Hyaluronan Click for more detail	Sperm-secreted hyaluronidase (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	Hyaluronan fragments or hyaluronidase activates the NFŒ∫B pathway and induced Il6, Ccl4 and Ccl5 mRNA expression.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Ovulated Cumulus-Oocyte Complexes(COCs)	LRR	Q9QUK6.fasta	Q9QUK6	835	The chemokines secreted from COCs induced sperm capacitation and enhanced fertilization.	Sperm accumulation assay	18434414	2008	Pubchem Assay
PRRID_0296	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0296	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0297	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0297	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Upon ligand engagement TLR proteins trigger downstream cellular signaling, leading to the activation of NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Porcine	Lymph node tissue	LRR	NA	NA	NA	It has a immunostimulatory role	NF-	18439678	2008	NA
PRRID_0298	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	imiquimod leads to decreased tyrosinase and MITF expression and is accompanied by decreased pigmentation.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Melanocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	It inhibits Melanogenesis and Proliferation of Human Melanocytes.	NA	18596825	2008	Pubchem Assay
PRRID_0298	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	imiquimod leads to decreased tyrosinase and MITF expression and is accompanied by decreased pigmentation.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Melanocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	It inhibits Melanogenesis and Proliferation of Human Melanocytes.	NA	18596825	2008	Pubchem Assay
PRRID_0299	Imiquimod (R837) Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0299	Imiquimod (R837) Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces astrocyte activation and up-regulation of proinflammatory cytokines and chemokines, including IFN-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Newborn Mice	Astrocytes and microglia	LRR	P58681.fasta	P58681	1050	It induces a neuroinflammatory response in CNS.	Cytokines assay	18490763	2008	Pubchem Assay
PRRID_0301	Lipid A Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	Stimulation via LPS leads to the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0301	Lipid A Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	Stimulation via LPS leads to the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	HEK293 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0302	Lipid A Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293 cells	LRR	O00206.fasta	O00206	839	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay
PRRID_0302	Lipid A Click for more detail	Burkholderia pseudomallei(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	Stimulation via LPS leads to the activation of NF-KappaB, which resulted into the production of TNF-Œ±, MIP-2, and IL-10.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293 cells	LRR	O00206.fasta	O00206	839	It has a immunostimulatory role	ELISA	18691413	2008	Pubchem Assay

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