| Primary information |
|---|
| PRRID | PRRID_0271 |
| Ligand Name | AM3 |
| Source | Immunomodulatory drug (others) |
| Sequence of ligand | NA |
| Length | NA |
| Type | Glycoconjugate |
| Occurence | Synthetic |
| Role of Ligand | AM3 induces NF-kB activation, IkB-a degradation and MAPK phosphorylationand enhanced the expression of CD54, CD83, CD86, HLA-DR, chemokines and chemokine receptors, interleukin (IL)-12p70 and IL-10. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | Monocytederived Dendritic cells (MDDCs) |
| Domain | LRR |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | AM3 induces human MDDC maturation, enhance and activates the T-cell proliferation and promotes MDDC maturation in patients with chronic HCV infection. |
| Assay used | ELISA |
| PMID | 18414382 |
| Year of Publication | 2008 |
| Pubchem assay | Pubchem Assay |
| Primary information |
|---|
| PRRID | PRRID_0271 |
| Ligand Name | AM3 |
| Source | Immunomodulatory drug (others) |
| Sequence of ligand | NA |
| Length | NA |
| Type | Glycoconjugate |
| Occurence | Synthetic |
| Role of Ligand | AM3 induces NF-kB activation, IkB-a degradation and MAPK phosphorylationand enhanced the expression of CD54, CD83, CD86, HLA-DR, chemokines and chemokine receptors, interleukin (IL)-12p70 and IL-10. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | Monocytederived Dendritic cells (MDDCs) |
| Domain | LRR |
| Sequence of Receptor | O00206.fasta |
| Swiss prot ID | O00206 |
| Length Of Receptor | 839 |
| Function | AM3 induces human MDDC maturation, enhance and activates the T-cell proliferation and promotes MDDC maturation in patients with chronic HCV infection. |
| Assay used | ELISA |
| PMID | 18414382 |
| Year of Publication | 2008 |
| Pubchem assay | Pubchem Assay |