PRRID_1370 | imidazoquinoline (R848 (also known as Resiquimod)) Click for more detail | A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN) | extracellular domain (ECD) | Q9NR97.fasta | Q9NR97 | 1041 | controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation | Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot | 24813206 | 2014 | Pubchem_assay | |