Detailed description page of PRRDB2.0

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PRRID_1356 details
Primary information
PRRIDPRRID_1356
Ligand NameHyaluronic acid
Sourceplasma membrane (others)
Sequence of ligandCC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O
LengthNA
TypeDamage-associated molecular patterns (DAMPs)
OccurenceNatural
Role of Ligandthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localization(DCs)Dendritic cells
Domaincell surface
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedNA
PMID24825061
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1356
Ligand NameHyaluronic acid
Sourceplasma membrane (others)
Sequence of ligandCC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O
LengthNA
TypeDamage-associated molecular patterns (DAMPs)
OccurenceNatural
Role of Ligandthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localization(DCs)Dendritic cells
Domaincell surface
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedNA
PMID24825061
Year of Publication2014
Pubchem assayPubchem_assay