| Primary information |
|---|
| PRRID | PRRID_1378 |
| Ligand Name | Imiquimod (R837) |
| Source | Virus |
| Sequence of ligand | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N |
| Length | NA |
| Type | Nucleic Acid |
| Occurence | Synthetic |
| Role of Ligand | treatment of genital warts and malignant tumors of the skin and also act as immune modulator |
| Name of receptor | Toll-like receptor 7 (TLR7) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | plasmacytoid and myeloid DCs |
| Domain | extracellular domain (ECD) |
| Sequence of Receptor | Q9NYK1.fasta |
| Swiss prot ID | Q9NYK1 |
| Length Of Receptor | 1049 |
| Function | human plasmacytoid dendritic cells (pDC) TLR7 signaling induces cell maturation, differentiation and type I IFN production via IRF5 and 7. |
| Assay used | Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot |
| PMID | 24813206 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |
| Primary information |
|---|
| PRRID | PRRID_1378 |
| Ligand Name | Imiquimod (R837) |
| Source | Virus |
| Sequence of ligand | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N |
| Length | NA |
| Type | Nucleic Acid |
| Occurence | Synthetic |
| Role of Ligand | treatment of genital warts and malignant tumors of the skin and also act as immune modulator |
| Name of receptor | Toll-like receptor 7 (TLR7) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | plasmacytoid and myeloid DCs |
| Domain | extracellular domain (ECD) |
| Sequence of Receptor | Q9NYK1.fasta |
| Swiss prot ID | Q9NYK1 |
| Length Of Receptor | 1049 |
| Function | human plasmacytoid dendritic cells (pDC) TLR7 signaling induces cell maturation, differentiation and type I IFN production via IRF5 and 7. |
| Assay used | Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot |
| PMID | 24813206 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |