Primary information |
---|
PRRID | PRRID_1369 |
Ligand Name | imidazoquinoline (R848 (also known as Resiquimod)) |
Source | A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring |
Sequence of ligand | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N |
Length | NA |
Type | Pattern-associated molecular patterns (PAMPs) |
Occurence | Synthetic |
Role of Ligand | Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic |
Name of receptor | Toll-like receptor 7 (TLR7) |
Type of receptor | Toll-like receptor (TLR) |
Source | Human |
Localization | monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN) |
Domain | extracellular domain (ECD) |
Sequence of Receptor | Q9NYK1.fasta |
Swiss prot ID | Q9NYK1 |
Length Of Receptor | 1049 |
Function | controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation |
Assay used | Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot |
PMID | 24813206 |
Year of Publication | 2014 |
Pubchem assay | Pubchem_assay |
Primary information |
---|
PRRID | PRRID_1369 |
Ligand Name | imidazoquinoline (R848 (also known as Resiquimod)) |
Source | A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring |
Sequence of ligand | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N |
Length | NA |
Type | Pattern-associated molecular patterns (PAMPs) |
Occurence | Synthetic |
Role of Ligand | Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic |
Name of receptor | Toll-like receptor 7 (TLR7) |
Type of receptor | Toll-like receptor (TLR) |
Source | Human |
Localization | monocyte-derived dendritic cells,polymorphonuclear leukocytes (PMN) |
Domain | extracellular domain (ECD) |
Sequence of Receptor | Q9NYK1.fasta |
Swiss prot ID | Q9NYK1 |
Length Of Receptor | 1049 |
Function | controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation |
Assay used | Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot |
PMID | 24813206 |
Year of Publication | 2014 |
Pubchem assay | Pubchem_assay |