Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0522flagellin and functional type III or Type IV secretion systems

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Legionella pneumophila (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalTheir bining activate the caspase-1 platformNod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANAimplicated in the restriction of Legionella growth in macrophages,NA206054292010NA
PRRID_0522flagellin and functional type III or Type IV secretion systems

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Legionella pneumophila (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalTheir bining activate the caspase-1 platformNod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANAimplicated in the restriction of Legionella growth in macrophages,NA206054292010NA
PRRID_0523flg22

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BacteriaQRLSTGSRINSAKDDAAGLQIA22PeptideNaturalIt bind to the FLS2 and incites the downstream cascade.FLS2Pattern recognition receptor (PRR)ArabidopsisPlasma membraneLRRQ9FL28.fastaQ9FL281173It caused seedling growth inhibition of arabidopsis thalianaGrowth inhibition assay202001502010Pubchem Assay
PRRID_0523flg22

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BacteriaQRLSTGSRINSAKDDAAGLQIA22PeptideNaturalIt bind to the FLS2 and incites the downstream cascade.FLS2Pattern recognition receptor (PRR)ArabidopsisPlasma membraneLRRQ9FL28.fastaQ9FL281173It caused seedling growth inhibition of arabidopsis thalianaGrowth inhibition assay202001502010Pubchem Assay
PRRID_0525FSL-1

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Mycoplasma (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticFSL-1 binds to the heterocomplex of TLR2 and TLR6 and activates the downstream signallingToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainQ9BXR5.fastaQ9BXR5811It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0525FSL-1

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Mycoplasma (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticFSL-1 binds to the heterocomplex of TLR2 and TLR6 and activates the downstream signallingToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainQ9BXR5.fastaQ9BXR5811It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0526FSL-1

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Mycoplasma salivarium (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticBinding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceembryonic mouse telencephalon and NPCLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784its activation inhibits NPC proliferation and decreases cell proliferation.NA204560212010Pubchem Assay
PRRID_0526FSL-1

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Mycoplasma salivarium (Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=ON[C@@H(COC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNALipoproteinSyntheticBinding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokinesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Miceembryonic mouse telencephalon and NPCLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784its activation inhibits NPC proliferation and decreases cell proliferation.NA204560212010Pubchem Assay
PRRID_0534genomic DNA

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Salmonella enterica (Bacteria)NANANucleic AcidNaturalThe binding leads to the activation of the NF-chToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenHD11 macrophageLeucine-rich Repeat (LRR) DomainNANANAIt leads to the inflammatory response from the immune system leads to the clearance of pathogensLuciferase assay204983582010NA
PRRID_0534genomic DNA

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Salmonella enterica (Bacteria)NANANucleic AcidNaturalThe binding leads to the activation of the NF-chToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenHD11 macrophageLeucine-rich Repeat (LRR) DomainNANANAIt leads to the inflammatory response from the immune system leads to the clearance of pathogensLuciferase assay204983582010NA
PRRID_0538Glycolipids

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spirochetes (Bacteria)NANAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA206794452010NA
PRRID_0538Glycolipids

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spirochetes (Bacteria)NANAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA206794452010NA
PRRID_0548Heat-killed MTB

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Mycobacterium tuberculosis (Bacteria)NANAWhole organismNaturalIt induces the production of IL-17AToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanPBMCsLRRO00206.fastaO00206839The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasisCytokines assay202996822010Pubchem Assay
PRRID_0548Heat-killed MTB

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Mycobacterium tuberculosis (Bacteria)NANAWhole organismNaturalIt induces the production of IL-17AToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanPBMCsLRRO00206.fastaO00206839The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasisCytokines assay202996822010Pubchem Assay
PRRID_0549Heat-killed MTB

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Mycobacterium tuberculosis (Bacteria)NANAWhole organismNaturalIt induces the production of IL-17ADectin-1C type Lectin (CTL/CLR)HumanPBMCsNAQ9BXN2.fastaQ9BXN2247The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasisCytokines assay202996822010Pubchem Assay
PRRID_0549Heat-killed MTB

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Mycobacterium tuberculosis (Bacteria)NANAWhole organismNaturalIt induces the production of IL-17ADectin-1C type Lectin (CTL/CLR)HumanPBMCsNAQ9BXN2.fastaQ9BXN2247The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasisCytokines assay202996822010Pubchem Assay
PRRID_0554hemolysin and multifunctional repeat-in-toxin (MARTX)

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Vibrio vulnificus (Bacteria)MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY4595ProteinNaturalIt elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.Nod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacropahesNAQ8R4B8.fastaQ8R4B81033It leads to the pathogen clearanceELISA203484252010Pubchem Assay
PRRID_0554hemolysin and multifunctional repeat-in-toxin (MARTX)

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Vibrio vulnificus (Bacteria)MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY4595ProteinNaturalIt elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.Nod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacropahesNAQ8R4B8.fastaQ8R4B81033It leads to the pathogen clearanceELISA203484252010Pubchem Assay
PRRID_0555hemolysin and multifunctional repeat-in-toxin (MARTX)

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Vibrio cholerae (Bacteria)MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL4558ProteinNaturalIt elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.Nod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacrophagesNAQ8R4B8.fastaQ8R4B81033It leads to the pathogen clearanceELISA203484252010Pubchem Assay
PRRID_0555hemolysin and multifunctional repeat-in-toxin (MARTX)

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Vibrio cholerae (Bacteria)MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL4558ProteinNaturalIt elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion.Nod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacrophagesNAQ8R4B8.fastaQ8R4B81033It leads to the pathogen clearanceELISA203484252010Pubchem Assay
PRRID_0565HpaA

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H. pylori (Bacteria)NANALipoproteinNaturalIt activates the TLR2, which leads to the secretion of IL-12 and IFN-Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNatural Killer cellsLRRO60603.fastaO60603784It has a immunostimulatory roleELISA201301072010Pubchem Assay
PRRID_0565HpaA

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H. pylori (Bacteria)NANALipoproteinNaturalIt activates the TLR2, which leads to the secretion of IL-12 and IFN-Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNatural Killer cellsLRRO60603.fastaO60603784It has a immunostimulatory roleELISA201301072010Pubchem Assay
PRRID_0601LAM

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Mycobacteria (Bacteria)OC[C@H]1O[C@@H](S[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@H](O)[C@@H](CO)O[C@H](Oc4ccc(cc4)[N+]([O-])=O)[C@@H]3O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1ONAPattern-associated molecular patterns (PAMPs)NaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0601LAM

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Mycobacteria (Bacteria)OC[C@H]1O[C@@H](S[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@H](O)[C@@H](CO)O[C@H](Oc4ccc(cc4)[N+]([O-])=O)[C@@H]3O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1ONAPattern-associated molecular patterns (PAMPs)NaturalIncreases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLung's endothelial cellLeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784It has the role in the inflammation.NA207066582010Pubchem Assay
PRRID_0603lethal toxin (LeTx)

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Bacillus anthracis(Bacteria)NANAtoxinNaturalIt’s binding to the IPAF leads to the activation of caspase-1 via ASC adaptor protein Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)MiceMacropahgesNAQ2LKU9.fastaQ2LKU91182It activates the inflammasome via NLRP1NA203038732010Pubchem Assay
PRRID_0603lethal toxin (LeTx)

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Bacillus anthracis(Bacteria)NANAtoxinNaturalIt’s binding to the IPAF leads to the activation of caspase-1 via ASC adaptor protein Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)MiceMacropahgesNAQ2LKU9.fastaQ2LKU91182It activates the inflammasome via NLRP1NA203038732010Pubchem Assay
PRRID_0604lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0604lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0605lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0605lipo-arabinomannan

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Mycobacteria (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0606lipo-arabinomannan

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M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalBinding of ligand leads to the inhibition of phagolysosome maturationMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456It ensure its survival of M. toberculosis in the hostNA204887842010Pubchem Assay
PRRID_0606lipo-arabinomannan

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M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalBinding of ligand leads to the inhibition of phagolysosome maturationMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456It ensure its survival of M. toberculosis in the hostNA204887842010Pubchem Assay
PRRID_0607lipomannas

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M. tuberculosis (Bacteria)NANAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0607lipomannas

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M. tuberculosis (Bacteria)NANAGlycolipidNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0608Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalK63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagyToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Plasma MembraneLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It leads to autophagy and hence clearance of the pathogenNA207986082010Pubchem Assay
PRRID_0608Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalK63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagyToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)Plasma MembraneLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It leads to autophagy and hence clearance of the pathogenNA207986082010Pubchem Assay
PRRID_0609Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalOn binding to the receptor it leads to the release of an array of cytokinesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)P815 cellsNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Immunostimulation and inflammationNA207985182010Pubchem Assay
PRRID_0609Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalOn binding to the receptor it leads to the release of an array of cytokinesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)P815 cellsNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Immunostimulation and inflammationNA207985182010Pubchem Assay
PRRID_0610Lipopolysaccharide (LPS)

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M. tuberculosis (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0610Lipopolysaccharide (LPS)

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M. tuberculosis (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0611Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0611Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0614Lipopolysaccharide (LPS)

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S. aureus (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)C57BL/6 MiceMacropahgesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0614Lipopolysaccharide (LPS)

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S. aureus (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLipopolysaccharides are the potent activators of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)C57BL/6 MiceMacropahgesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0615Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLps is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0615Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLps is a potent activator of TLR4Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanKeratinocytesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has the role in the inflammation.NA207289392010Pubchem Assay
PRRID_0616Lipopolysaccharide (LPS)

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Escherichia coli O111: B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicemacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207284332010Pubchem Assay
PRRID_0616Lipopolysaccharide (LPS)

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Escherichia coli O111: B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)MicemacrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It has the role in the inflammation.NA207284332010Pubchem Assay
PRRID_0617Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalReduced HIV-1 expression and cell toxicity in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0617Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalReduced HIV-1 expression and cell toxicity in macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0618Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0618Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0619Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR-4 Thre399Ile)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0619Lipopolysaccharide (LPS)

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Salmonella minnesota (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR-4 Thre399Ile)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANADownregulate inflammation in FMF patientsNA207147962010NA
PRRID_0620Lipopolysaccharide (LPS)

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Bacterial strainsCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0620Lipopolysaccharide (LPS)

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Bacterial strainsCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0623Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver diseaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacropahgesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the inflammation of the cellsNA207066772010Pubchem Assay
PRRID_0623Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver diseaseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMacropahgesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leads to the inflammation of the cellsNA207066772010Pubchem Assay
PRRID_0625Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces the expression of nociceptin, an opioid-related neuropeptideNA207066422010Pubchem Assay
PRRID_0625Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanneuronsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces the expression of nociceptin, an opioid-related neuropeptideNA207066422010Pubchem Assay
PRRID_0626Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMicrogliaLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injuryNA207066422010Pubchem Assay
PRRID_0626Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanMicrogliaLeucine-rich Repeat (LRR) DomainO60602.fastaO60602858It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injuryNA207066422010Pubchem Assay
PRRID_0627Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)CNSNALeucine-rich Repeat (LRR) DomainNANANAIt cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampusNA207066422010NA
PRRID_0627Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)CNSNALeucine-rich Repeat (LRR) DomainNANANAIt cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampusNA207066422010NA
PRRID_0628Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)AD Mice's hippocampusmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Involved in the clearance of Aβ deposits in the brainNA207066422010Pubchem Assay
PRRID_0628Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)AD Mice's hippocampusmicrogliaLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835Involved in the clearance of Aβ deposits in the brainNA207066422010Pubchem Assay
PRRID_0635Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (cfLGBP)Pattern recognition receptor (PRR)Chlamys farreriHemocytes, gills and mantleNANANANAIt is involved in pathogens recognition and bacterial agglutination.NA206595622010NA
PRRID_0635Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (cfLGBP)Pattern recognition receptor (PRR)Chlamys farreriHemocytes, gills and mantleNANANANAIt is involved in pathogens recognition and bacterial agglutination.NA206595622010NA
PRRID_0639Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B8 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)Wistar RatPineal gland (pinealocytes)NAQ63691.fastaQ63691372The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF and inhibiting melatonin synthesisNA205868882010Pubchem Assay
PRRID_0639Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B8 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)Wistar RatPineal gland (pinealocytes)NAQ63691.fastaQ63691372The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF and inhibiting melatonin synthesisNA205868882010Pubchem Assay
PRRID_0640Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B9 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Wistar RatPineal gland (pinealocytes)Leucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory responseEMSA205868882010Pubchem Assay
PRRID_0640Lipopolysaccharide (LPS)

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Escherichia coli serotype 0127:B9 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBinding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Wistar RatPineal gland (pinealocytes)Leucine-rich Repeat (LRR) DomainQ9QX05.fastaQ9QX05835The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory responseEMSA205868882010Pubchem Assay
PRRID_0641Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP2Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0641Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP2Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0642Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAGmCP8Pattern recognition receptor (PRR)Galleria mellonellahemolymphNANANANAIt has opsonin activity for the phagocytosis of the microorganisms by hemocytes.NA205195172010NA
PRRID_0642Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAGmCP8Pattern recognition receptor (PRR)Galleria mellonellahemolymphNANANANAIt has opsonin activity for the phagocytosis of the microorganisms by hemocytes.NA205195172010NA
PRRID_0643Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt is the responsive PAMP for the FcLec5FcLec5C type Lectin (CTL/CLR)Fenneropenaeus chinensishepatopancreasCRDNANANAIt elicit the immune response, which leads to the clearance of bacteriaELISA203493232010NA
PRRID_0643Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt is the responsive PAMP for the FcLec5FcLec5C type Lectin (CTL/CLR)Fenneropenaeus chinensishepatopancreasCRDNANANAIt elicit the immune response, which leads to the clearance of bacteriaELISA203493232010NA
PRRID_0644Lipopolysaccharide (LPS)

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Escherichia coli strain 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the release of microparticles by the macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacropahesLRRQ9QUK6.fastaQ9QUK6835It leads to the release of MPs which act as the novel signals for innate immunityGriess assay203353122010Pubchem Assay
PRRID_0644Lipopolysaccharide (LPS)

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Escherichia coli strain 0111:B4 (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the release of microparticles by the macrophagesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)MacropahesLRRQ9QUK6.fastaQ9QUK6835It leads to the release of MPs which act as the novel signals for innate immunityGriess assay203353122010Pubchem Assay
PRRID_0646Lipoprotein

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Staphylococcus epidermis & aureus (Bacteria)NANALipoproteinNaturalTLR-2 mediated by the NF-kB pathway in septic arthritic chondrocytes and cytokine productionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Septic Chondrocytes from homo sapiensNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207406732010Pubchem Assay
PRRID_0646Lipoprotein

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Staphylococcus epidermis & aureus (Bacteria)NANALipoproteinNaturalTLR-2 mediated by the NF-kB pathway in septic arthritic chondrocytes and cytokine productionToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Septic Chondrocytes from homo sapiensNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207406732010Pubchem Assay
PRRID_0647Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturalLipoprotein binds to the TLR2 and activates the downstream cascadesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207292072010Pubchem Assay
PRRID_0647Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturalLipoprotein binds to the TLR2 and activates the downstream cascadesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207292072010Pubchem Assay
PRRID_0649Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturallipoprotein and lipoarabinomannan are the poteny activators of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0649Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturallipoprotein and lipoarabinomannan are the poteny activators of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0650Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalTheir binding to the TLR2 leads to the activation of the downstream signallingToll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57/BL Mice cell lineNALeucine-rich Repeat (LRR) DomainO53505.fastaO53505227maturation of the Dendritic cellsNA207953862010Pubchem Assay
PRRID_0650Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalTheir binding to the TLR2 leads to the activation of the downstream signallingToll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57/BL Mice cell lineNALeucine-rich Repeat (LRR) DomainO53505.fastaO53505227maturation of the Dendritic cellsNA207953862010Pubchem Assay
PRRID_0651lipo-arabinomannan

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M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturallipoprotein and lipoarabinomannan are the poteny activators of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0651lipo-arabinomannan

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M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturallipoprotein and lipoarabinomannan are the poteny activators of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)DNA samples from peripheral blood of TB patientsNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Immunostimulation and inflammationNA207979052010Pubchem Assay
PRRID_0652Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimerToll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAIt coauses the inflammationNA207403412010NA
PRRID_0652Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimerToll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAIt coauses the inflammationNA207403412010NA
PRRID_0653Lipoteichoic Acid (LTA)

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E. coli(Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalPeptidoglycan is the potent activator of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0653Lipoteichoic Acid (LTA)

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E. coli(Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalPeptidoglycan is the potent activator of the TLR2Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 MiceNALeucine-rich Repeat (LRR) DomainQ9QUN7.fastaQ9QUN7784Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implantsNA207292142010Pubchem Assay
PRRID_0654Lipoteichoic Acid (LTA)

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Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalEnhanced HIV-1 expression in macrophagesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0654Lipoteichoic Acid (LTA)

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Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalEnhanced HIV-1 expression in macrophagesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0655Lipoteichoic Acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNAToll-like receptor 2 Arg753Gln (TLR-2 Arg753Gln)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANAUpregulate inflammation in FMF patientsNA207147962010NA
PRRID_0655Lipoteichoic Acid (LTA)

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BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNAToll-like receptor 2 Arg753Gln (TLR-2 Arg753Gln)Toll-like receptor (TLR)FMF patientsmonocytes and granulocytesLeucine-rich Repeat (LRR) DomainNANANAUpregulate inflammation in FMF patientsNA207147962010NA
PRRID_0657Lipoteichoic Acid (LTA)

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Streptococcus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainNANANAIt leadsto the secretion of the proinfalmmatory cytokinesNA206201292010NA
PRRID_0657Lipoteichoic Acid (LTA)

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Streptococcus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainNANANAIt leadsto the secretion of the proinfalmmatory cytokinesNA206201292010NA