Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1321	Heat-shock proteins 60 Click for more detail	NA	MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	initiates an inflammatory response by activating innate immune cells	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1321	Heat-shock proteins 60 Click for more detail	NA	MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	initiates an inflammatory response by activating innate immune cells	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1323	Heat-shock proteins 60 Click for more detail	NA	MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	initiates an inflammatory response by activating innate immune cells	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24801735	2014	Pubchem_assay
PRRID_1323	Heat-shock proteins 60 Click for more detail	NA	MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	initiates an inflammatory response by activating innate immune cells	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24801735	2014	Pubchem_assay
PRRID_1324	Heat-shock proteins 60 Click for more detail	NA	MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1324	Heat-shock proteins 60 Click for more detail	NA	MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1327	Heparan sulfate Click for more detail	Host (Endogenous) (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	induce the maturation of DCs	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1327	Heparan sulfate Click for more detail	Host (Endogenous) (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	induce the maturation of DCs	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1329	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	24830024	2014	NA
PRRID_1329	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	24830024	2014	NA
PRRID_1330	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24830024	2014	Pubchem_assay
PRRID_1330	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24830024	2014	Pubchem_assay
PRRID_1331	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1331	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	24830024	2014	Pubchem_assay
PRRID_1332	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1332	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1334	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play a critical role in the pathogenesis of inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemic Mice	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	HMGB1-TLR4 signaling can activate macrophages and up-regulate the expression of cytokines	qRT-PCR, immunofluorescence assay, western blot	24802390	2014	Pubchem_assay
PRRID_1334	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play a critical role in the pathogenesis of inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemic Mice	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	HMGB1-TLR4 signaling can activate macrophages and up-regulate the expression of cytokines	qRT-PCR, immunofluorescence assay, western blot	24802390	2014	Pubchem_assay
PRRID_1335	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1335	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1337	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	released in brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1337	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	released in brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1339	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1339	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	play an important role in infectious inflammatory responses.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1341	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1341	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1343	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1343	HMGB1 Click for more detail	NA	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 is a key regulator of nucleosome formation and gene transcription that acts as a cytokine following cell injury.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1345	Host RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1345	Host RNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q99MB1.fasta	Q99MB1	905	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1347	HSP Gp96 Click for more detail	NA	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	endogenous Ligand HSP70 induces proinflammatory cytokines through TLR2 and initiates an inflammatory response by activating innate immune cells	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1347	HSP Gp96 Click for more detail	NA	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	endogenous Ligand HSP70 induces proinflammatory cytokines through TLR2 and initiates an inflammatory response by activating innate immune cells	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1349	HSP Gp96 Click for more detail	NA	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	endogenous Ligand HSP Gp96 induces proinflammatory cytokines through TLR2 and TLR4 signaling	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1349	HSP Gp96 Click for more detail	NA	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	endogenous Ligand HSP Gp96 induces proinflammatory cytokines through TLR2 and TLR4 signaling	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1351	Hsp90 Click for more detail	NA	MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPEIEDVGSDEEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPLEGDDDTSRMEEVD	733	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1351	Hsp90 Click for more detail	NA	MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPEIEDVGSDEEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPLEGDDDTSRMEEVD	733	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1354	Hyaluronan Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1354	Hyaluronan Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1356	Hyaluronic acid Click for more detail	plasma membrane (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1356	Hyaluronic acid Click for more detail	plasma membrane (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	(DCs)Dendritic cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24825061	2014	Pubchem_assay
PRRID_1358	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1358	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1360	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1360	Hyaluronic acid Click for more detail	NA	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1362	hyaluronic acid oligosaccharides Click for more detail	plasma membrane (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1362	hyaluronic acid oligosaccharides Click for more detail	plasma membrane (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1366	IL-2 and R848 Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	selectively stimulate human memory B cells, leading to differentiation of IgG-secreting AFC (Antibody forming cells)	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	NA	NA	NA	selectively stimulate human memory B cells, leading to differentiation of IgG-secreting AFC	ELISPOT assay, Proliferation assay	24828435	2014	NA
PRRID_1366	IL-2 and R848 Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	selectively stimulate human memory B cells, leading to differentiation of IgG-secreting AFC (Antibody forming cells)	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	NA	NA	NA	selectively stimulate human memory B cells, leading to differentiation of IgG-secreting AFC	ELISPOT assay, Proliferation assay	24828435	2014	NA
PRRID_1367	Imidazoquinoline Click for more detail	tricyclic organic molecule (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1367	Imidazoquinoline Click for more detail	tricyclic organic molecule (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	P58681.fasta	P58681	1050	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1368	Imidazoquinoline Click for more detail	tricyclic organic molecule (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1368	Imidazoquinoline Click for more detail	tricyclic organic molecule (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	induce type I IFN, antiviral and antitumor therapeutic molecules	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	P58682.fasta	P58682	1032	important role in the immune response to viral infection	NA	24830024	2014	Pubchem_assay
PRRID_1372	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleen cells	cell compartment	P58681.fasta	P58681	1050	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1372	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleen cells	cell compartment	P58681.fasta	P58681	1050	important role in the immune response to viral infection	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1379	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	treatment of genital warts and malignant tumors of the skin and also act as immune modulator	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	extracellular domain (ECD)	P58681.fasta	P58681	1050	human plasmacytoid dendritic cells (pDC) TLR7 signaling induces cell maturation, differentiation and type I IFN production via IRF5 and 7.	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1379	Imiquimod (R837) Click for more detail	Virus	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	treatment of genital warts and malignant tumors of the skin and also act as immune modulator	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid and myeloid DCs	extracellular domain (ECD)	P58681.fasta	P58681	1050	human plasmacytoid dendritic cells (pDC) TLR7 signaling induces cell maturation, differentiation and type I IFN production via IRF5 and 7.	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1381	internalized flagellin Click for more detail	Salmonella typhimurium or Legionella pneumophila (Bacteria)	KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL	76	Protein	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	medullary collecting duct (MCD) cells	intracellular receptors	Q3UP24.fasta	Q3UP24	1024	assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1Œ≤ and IL-18	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1381	internalized flagellin Click for more detail	Salmonella typhimurium or Legionella pneumophila (Bacteria)	KLSFEDKNGKVIDGGYAVKMGDDFYAATYDEKTGAITAKTTTYTDGTGVAQTGAVKFGGANGKSEVVTATDGKTYL	76	Protein	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	medullary collecting duct (MCD) cells	intracellular receptors	Q3UP24.fasta	Q3UP24	1024	assemble in an inflammasome complex to activate caspase-1 and promote the release of IL-1Œ≤ and IL-18	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1383	isomers of opioid ligands Click for more detail	opioid (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	It is primarily used for pain relief, cough and constipation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	spinal microglia, macrophage and astrocytes	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24824631	2014	Pubchem_assay
PRRID_1383	isomers of opioid ligands Click for more detail	opioid (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	It is primarily used for pain relief, cough and constipation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	spinal microglia, macrophage and astrocytes	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24824631	2014	Pubchem_assay
PRRID_1384	isomers of opioids Click for more detail	opioid (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	It is primarily used for pain relief, cough and constipation	mu opioid receptors	mu opioid receptors	Mice	central nervous system. mu opioid receptors are found on pre- and post-synaptic nociceptive neurons, as well as on astrocytes and microglia	NA	P42866.fasta	P42866	398	It is an inhibitory G-protein coupled receptor	NA	24824631	2014	Pubchem_assay
PRRID_1384	isomers of opioids Click for more detail	opioid (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	It is primarily used for pain relief, cough and constipation	mu opioid receptors	mu opioid receptors	Mice	central nervous system. mu opioid receptors are found on pre- and post-synaptic nociceptive neurons, as well as on astrocytes and microglia	NA	P42866.fasta	P42866	398	It is an inhibitory G-protein coupled receptor	NA	24824631	2014	Pubchem_assay
PRRID_1386	L-ornithine muramyl tripeptide Click for more detail	Gram-positive bacteria and some Gram-negative spirochaetes.	CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCNC(=O)[C@H](C)NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(=O)C)C=O)C(=O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Natural	in vitro activates Nod	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	immune cells like peripheral blood monocytes, granulocytes and dendritic cells, as well as in astrocytes of the brain and in paneth cells of the gut	intracellular receptors	Q8K3Z0.fasta	Q8K3Z0	1020	Nod2, are associ- ated with inflammatory bowel disease in humans	NA	24779390	2014	Pubchem_assay
PRRID_1386	L-ornithine muramyl tripeptide Click for more detail	Gram-positive bacteria and some Gram-negative spirochaetes.	CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCNC(=O)[C@H](C)NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(=O)C)C=O)C(=O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Peptide	Natural	in vitro activates Nod	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	immune cells like peripheral blood monocytes, granulocytes and dendritic cells, as well as in astrocytes of the brain and in paneth cells of the gut	intracellular receptors	Q8K3Z0.fasta	Q8K3Z0	1020	Nod2, are associ- ated with inflammatory bowel disease in humans	NA	24779390	2014	Pubchem_assay
PRRID_1389	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1389	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24757287	2014	Pubchem_assay
PRRID_1391	lipo-phosphoglycan Click for more detail	Leishmania (others)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24801735	2014	Pubchem_assay
PRRID_1391	lipo-phosphoglycan Click for more detail	Leishmania (others)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	ELISA	24801735	2014	Pubchem_assay
PRRID_1392	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell surface	Q9EPQ1.fasta	Q9EPQ1	795	NA	NA	24807166	2014	Pubchem_assay
PRRID_1392	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, DCs and B-lymphocytes	Cell surface	Q9EPQ1.fasta	Q9EPQ1	795	NA	NA	24807166	2014	Pubchem_assay
PRRID_1394	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1394	Lipopeptides Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	extracellular domains of leucine-rich repeat motifs	Q9QUN7.fasta	Q9QUN7	784	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1397	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24830024	2014	Pubchem_assay
PRRID_1397	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24830024	2014	Pubchem_assay
PRRID_1398	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1398	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	Cell Surface (Exogenous)	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	reverse transcription‚Äìpolymerase chain reaction (RT‚ÄìPCR), real-time RT‚ÄìPCR, flow cytometry, immunocytochemistry and Western blot analysis.	24828022	2014	Pubchem_assay
PRRID_1402	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24818579	2014	Pubchem_assay
PRRID_1402	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induces a strong response from normal animal immune systems	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24818579	2014	Pubchem_assay
PRRID_1405	Lipopolysaccharide (LPS) Click for more detail	outer cell wall component of gram- negative bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	responsible for an endotoxin shock	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1405	Lipopolysaccharide (LPS) Click for more detail	outer cell wall component of gram- negative bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	responsible for an endotoxin shock	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	Q9QUK6.fasta	Q9QUK6	835	Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1407	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemic Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 recognizes LPS and causes cell activation, including the production of NO and proinflammatory cytokines such as TNF-Œ± and IL-6	qRT-PCR, immunofluorescence assay, western blot	24802390	2014	Pubchem_assay
PRRID_1407	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endotoxemic Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 recognizes LPS and causes cell activation, including the production of NO and proinflammatory cytokines such as TNF-Œ± and IL-6	qRT-PCR, immunofluorescence assay, western blot	24802390	2014	Pubchem_assay
PRRID_1408	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24801735	2014	Pubchem_assay
PRRID_1408	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	induce inflammation	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	TLR-deficient Mice on a C57BL/6	monocyte/macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24801735	2014	Pubchem_assay
PRRID_1410	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1410	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Keratinocytes and mouse skin	cell surface	Q9QUK6.fasta	Q9QUK6	835	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1412	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1412	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	ischemic brain tissue	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon	NA	24784586	2014	Pubchem_assay
PRRID_1414	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	human MSCs (hMSCs) and murine MSCs (mMSCs)	cell surface	Q9QUK6.fasta	Q9QUK6	835	the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation	NA	24780395	2014	Pubchem_assay
PRRID_1414	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	human MSCs (hMSCs) and murine MSCs (mMSCs)	cell surface	Q9QUK6.fasta	Q9QUK6	835	the agonists of TLR3 and TLR4 in human MSCs (hMSCs) induce down- regulation of the of Notch ligand Jagged-1, and thus decrease the ability of MSCs to suppress allogeneic T cell proliferation	NA	24780395	2014	Pubchem_assay
PRRID_1416	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	murine bladder epithelial cells and renal tubule cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1416	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	murine bladder epithelial cells and renal tubule cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1418	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	expressed as a pseudo-gene	Cell Compartment/Intracellular (Endosome)	Q6R5P0.fasta	Q6R5P0	926	TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1418	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	Flagellin and LPS stimulate the production of CXCL1 and CXCL2	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	expressed as a pseudo-gene	Cell Compartment/Intracellular (Endosome)	Q6R5P0.fasta	Q6R5P0	926	TLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.	ELISA, adhesion and invasion assay	24779433	2014	Pubchem_assay
PRRID_1419	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	gingival epithelial cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	produce pro-inflammatory cytokines such as IL-8	ELISA	24773607	2014	Pubchem_assay
PRRID_1419	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	gingival epithelial cells	cell surface	Q9QUK6.fasta	Q9QUK6	835	produce pro-inflammatory cytokines such as IL-8	ELISA	24773607	2014	Pubchem_assay
PRRID_1421	Lipopolysaccharide (LPS) Click for more detail	E. coli O26:B6(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24771854	2014	Pubchem_assay
PRRID_1421	Lipopolysaccharide (LPS) Click for more detail	E. coli O26:B6(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	cell surface	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24771854	2014	Pubchem_assay
PRRID_1423	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling.	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24766885	2014	Pubchem_assay
PRRID_1423	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	it plays a dominant role in the induction of sepsis and hence is referred to as endotoxin	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages	MyD88, TIRAP, TRIF and TRAM are the best characterized TIR domain-containing proteins that serve as adaptors in TLR signaling.	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	24766885	2014	Pubchem_assay

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