Detailed description page of PRRDB2.0

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PRRID_1321 details
Primary information
PRRIDPRRID_1321
Ligand NameHeat-shock proteins 60
SourceNA
Sequence of ligandMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
Length573
TypeDamage-associated molecular patterns (DAMPs)
OccurenceNatural
Role of Ligandinitiates an inflammatory response by activating innate immune cells
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte
Domaincell surface
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionPossible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia
Assay usedNA
PMID24807166
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1321
Ligand NameHeat-shock proteins 60
SourceNA
Sequence of ligandMLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
Length573
TypeDamage-associated molecular patterns (DAMPs)
OccurenceNatural
Role of Ligandinitiates an inflammatory response by activating innate immune cells
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte
Domaincell surface
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionPossible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia
Assay usedNA
PMID24807166
Year of Publication2014
Pubchem assayPubchem_assay