Detailed description page of PRRDB2.0

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PRRID_1398 details
Primary information
PRRIDPRRID_1398
Ligand NameLipopolysaccharide (LPS)
SourceGram-negative bacteria
Sequence of ligandCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC
LengthNA
TypeLipopolysaccharide (LPS)
OccurenceNatural
Role of Ligandinduces a strong response from normal animal immune systems
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte
DomainCell Surface (Exogenous)
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedreverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis.
PMID24828022
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1398
Ligand NameLipopolysaccharide (LPS)
SourceGram-negative bacteria
Sequence of ligandCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC
LengthNA
TypeLipopolysaccharide (LPS)
OccurenceNatural
Role of Ligandinduces a strong response from normal animal immune systems
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte
DomainCell Surface (Exogenous)
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedreverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis.
PMID24828022
Year of Publication2014
Pubchem assayPubchem_assay