The Total number of records shown on this page is 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_133	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_134	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_135	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	25% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_136	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	16% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_137	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	1% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_138	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	5% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_139	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	20% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_140	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	32% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_141	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	3% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_142	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_143	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	30% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_144	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	32% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_145	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	15% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_146	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_147	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	33% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_148	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	51% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_149	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	20% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_150	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	26% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_151	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	49% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_152	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	98% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_153	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	25% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_154	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	40% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_155	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	54% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_156	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	58% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_157	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	28% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_158	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	45% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_159	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	50% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_160	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	58% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_161	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	30% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_162	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	40% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_163	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 2 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	50% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_164	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubacin - 5 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	70% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_165	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁷ MOI	5% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_166	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁷ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_167	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁷ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_168	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	9% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_169	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	6% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_170	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁶ MOI	3% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_171	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	15% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_172	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	10% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_173	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁵ MOI	5% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_174	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	40% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_175	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	44% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_176	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻⁴ MOI	43% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_177	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	49% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_178	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	46% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_179	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻³ MOI	42% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_180	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	51% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_181	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_182	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻² MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_183	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	51% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_184	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_185	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3⁻¹ MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_186	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	51% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_187	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_188	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	1 MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_189	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	54% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_190	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 1 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	52% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_191	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with CI994 - 3 micromolar starting at 14 hours before infection	No	NA	Human glioblastoma astrocytoma cell line	U251	NA	NA	LDH cytotoxicity assay	3 MOI	60% cancer cell death	No	No	NA	No response	NA	NA	NA	NA	26524593
OV_192	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nu/nu mice injected intracranially with GBM30 cells 1.0E+5 cells	5.0E+5 PFU (on 5 day) in total 8 mice	NA	40% mice survived on 28th day	Intratumorally	NA	NA	NA	26524593
OV_193	Herpes simplex virus	rQNestin34.5	DNA	Herpesviridae	Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter	No	Virus in combination with tubastatin A (TA) at a dose of 1.3 mg per kg body weight (4, 5, 6, 7 and 8 days after tumor implantation)	No	NA	NA	NA	NA	NA	NA	NA	NA	Female athymic nu/nu mice injected intracranially with GBM30 cells 1.0E+5 cells	5.0E+5 PFU (on 5 day) in total 8 mice	NA	80% mice survived on 28th day	Intratumorally	NA	NA	NA	26524593
OV_360	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	CHLA-20	4000 cells per well	NA	MTS cell survival assay	0.0001 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_361	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	CHP-134	4000 cells per well	NA	MTS cell survival assay	0.0001 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_362	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	SK-N-AS	4000 cells per well	NA	MTS cell survival assay	0.0001 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_363	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	SK-N-BE(2)	4000 cells per well	NA	MTS cell survival assay	0.0001 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_364	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	CHLA-20	4000 cells per well	NA	MTS cell survival assay	0.01 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_365	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	CHP-134	4000 cells per well	NA	MTS cell survival assay	0.01 MOI	18% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_366	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	SK-N-AS	4000 cells per well	NA	MTS cell survival assay	0.01 MOI	76% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_367	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	SK-N-BE(2)	4000 cells per well	NA	MTS cell survival assay	0.01 MOI	100% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_368	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	CHLA-20	4000 cells per well	NA	MTS cell survival assay	0.1 MOI	98% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_369	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	CHP-134	4000 cells per well	NA	MTS cell survival assay	0.1 MOI	1% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_370	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	SK-N-AS	4000 cells per well	NA	MTS cell survival assay	0.1 MOI	26% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_371	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	SK-N-BE(2)	4000 cells per well	NA	MTS cell survival assay	0.1 MOI	58% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_372	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	CHLA-20	4000 cells per well	NA	MTS cell survival assay	1 MOI	72% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_373	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	CHP-134	4000 cells per well	NA	MTS cell survival assay	1 MOI	1% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_374	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	SK-N-AS	4000 cells per well	NA	MTS cell survival assay	1 MOI	15% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_375	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	ATCC or from the Pediatric Preclinical Testing Program (PPTP)	Human neuroblastoma cell line	SK-N-BE(2)	4000 cells per well	NA	MTS cell survival assay	1 MOI	18% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26583803
OV_376	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice (subcutaneously xenografted with CHLA-20)	1.0E+7 pfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³)	NA	42% mice survived	Intratumorally	NA	NA	NA	26583803
OV_377	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice (subcutaneously xenografted with CHP-123)	1.0E+7 pfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³)	NA	63% mice survived	Intratumorally	NA	NA	NA	26583803
OV_378	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice (subcutaneously xenografted with SK-N-AS)	1.0E+7 pfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³)	NA	0% mice survived	Intratumorally	NA	NA	NA	26583803
OV_379	Herpes simplex virus	Seprehvir (HSV1716)	DNA	Herpesviridae	Δγ134.5 attenuated virus mutant	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic nude mice (subcutaneously xenografted with SK-N-BE(2))	1.0E+7 pfu in 100 μL (on days 0, 2 and 4 after the tumor mass reached 150–300 mm³)	NA	18% mice survived	Intratumorally	NA	NA	NA	26583803
OV_393	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	Yes	No	No	ATCC	Human malignant melanoma cell lines	A2058	NA	NA	Trypan blue staining	1 MOI	50% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_394	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with SP600125 (100 μM)	No	ATCC	Human malignant melanoma cell lines	A2058	NA	NA	Trypan blue staining	1 MOI	35% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_395	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with 3-MA (5 mM)	No	ATCC	Human malignant melanoma cell lines	A2058	NA	NA	Trypan blue staining	1 MOI	38% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_396	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with z-YVAD- fmk (100 μM)	No	ATCC	Human malignant melanoma cell lines	A2058	NA	NA	Trypan blue staining	1 MOI	44% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_397	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	Yes	No	No	ATCC	Human malignant melanoma cell lines	A375	NA	NA	Trypan blue staining	1 MOI	55% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_398	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with SP600125 (100 μM)	No	ATCC	Human malignant melanoma cell lines	A375	NA	NA	Trypan blue staining	1 MOI	35% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_399	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with 3-MA (5 mM)	No	ATCC	Human malignant melanoma cell lines	A375	NA	NA	Trypan blue staining	1 MOI	44% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_400	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	No	Viral strain in combination with z-YVAD- fmk (100 μM)	No	ATCC	Human malignant melanoma cell lines	A375	NA	NA	Trypan blue staining	1 MOI	42% cancer cell death at 48 hours after post infection	No	No	NA	No response	NA	Induces JNK/c-Jun, autophagy and pyroptosis activation	ICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes	NA	26602205
OV_401	Herpes simplex virus	ICP10PK	DNA	Herpesviridae	Deletion mutant with R1 domain poorly functional in HSV-1	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Xenograft male BALB/c nu/nu mice (subcutaneously injected with 1.0E+7 A3755 cells in 100 μl)	100 μl; 1.0E+6 PFU on day 7	NA	On day 29 , tumor growth ratio reached 2 as compared to 13 (tumour growth ratio - dividing each tumour volume measured over time by the initial tumour volume on day 7)	Intratumorally	NA	MICA and TNF-alpha expressions are upregulated	NA	26602205
OV_832	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	Natural	colorectal cancer cell line	C18	3.0E+4 cells per well	NA	Beta galacosidase colorimetric assay	0.1 MOI	31% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10428757
OV_833	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	Natural	colorectal cancer cell line	C29	3.0E+4 cells per well	NA	Beta galacosidase colorimetric assay	0.1 MOI	31% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10428757
OV_834	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	Natural	colorectal cancer cell line	C85	3.0E+4 cells per well	NA	Beta galacosidase colorimetric assay	0.1 MOI	76% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10428757
OV_835	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	Natural	colorectal cancer cell line	C86	3.0E+4 cells per well	NA	Beta galacosidase colorimetric assay	0.1 MOI	76% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10428757
OV_836	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	Natural	Cellosaurus cell line	HCT-8	3.0E+4 cells per well	NA	Beta galacosidase colorimetric assay	0.1 MOI	76% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	10428757
OV_837	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	No	No	NA	No response	NA	NA	NA	NA	10428757
OV_838	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic rat xenograft model for C85 cell line	1.0E+7 pfu	NA	No response	Direct injection	NA	NA	NA	10428757
OV_839	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic rat xenograft model for C86 cell line	1.0E+7 pfu	NA	4 xenograft model shows partial reduction and 2 shows complete reduction (50% reduction)	Direct injection	NA	NA	NA	10428757
OV_840	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Athymic rat xenograft model for HCT8 cell line	1.0E+7 pfu	NA	4 xenograft model shows complete reduction and 4 shows partial reduction (complete reduction)	Direct injection	NA	NA	NA	10428757
OV_841	Herpes simplex virus	HSV-G207	DNA	Herpesviridae	Deletion mutant of both copies of gamma 34.5 gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	Male buffalo rat xenograft model of Morris hepatome McA-RH7777 cell	1.0E+8 pfu	NA	Complete reduction in tumor nodes	Portal infusion	NA	NA	NA	10428757