Detailed description page of Selected OV_ID


OV_151 details
Primary information
OV_IDOV_151
Virus Name Herpes simplex virus
StrainrQNestin34.5
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with tubacin - 2 micromolar starting at 14 hours before infection
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineHuman glioblastoma astrocytoma cell line
Cell lineU251
Concentration of cell line0
In-vitro toxicityNA
AssayLDH cytotoxicity assay
In-vitro virus concentration3⁻² MOI
In-vitro result49% cancer cell death
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID26524593