Detailed description page of Selected OV_ID


OV_394 details
Primary information
OV_IDOV_394
Virus Name Herpes simplex virus
StrainICP10PK
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant with R1 domain poorly functional in HSV-1
Virus aloneNo
Virus in combination iwth drug/radiationViral strain in combination with SP600125 (100 μM)
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman malignant melanoma cell lines
Cell lineA2058
Concentration of cell line0
In-vitro toxicityNA
AssayTrypan blue staining
In-vitro virus concentration1 MOI
In-vitro result35% cancer cell death at 48 hours after post infection
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionInduces JNK/c-Jun, autophagy and pyroptosis activation
Immunogenic effectICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes
Clinical trialNA
PMID26602205