Detailed description page of Selected OV_ID


OV_400 details
Primary information
OV_IDOV_400
Virus Name Herpes simplex virus
StrainICP10PK
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant with R1 domain poorly functional in HSV-1
Virus aloneNo
Virus in combination iwth drug/radiationViral strain in combination with z-YVAD- fmk (100 μM)
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman malignant melanoma cell lines
Cell lineA375
Concentration of cell line0
In-vitro toxicityNA
AssayTrypan blue staining
In-vitro virus concentration1 MOI
In-vitro result42% cancer cell death at 48 hours after post infection
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionInduces JNK/c-Jun, autophagy and pyroptosis activation
Immunogenic effectICP10PK upregulates of caspase-1, -4, and -5, the cytokines IL-1alpha, IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, lymphotoxina and GM-CSF, and mitogen-activated protein kinases (MAPKs) involved in both PCD and inflammatory processes
Clinical trialNA
PMID26602205