| Primary information |
|---|
| OV_ID | OV_146 |
| Virus Name | Herpes simplex virus |
| Strain | rQNestin34.5 |
| Virus type | DNA |
| Virus family | Herpesviridae |
| Modification in virus genome | Deletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with tubacin - 1 micromolar starting at 14 hours before infection |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | Human glioblastoma astrocytoma cell line |
| Cell line | U251 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | LDH cytotoxicity assay |
| In-vitro virus concentration | 3â»Â³ MOI |
| In-vitro result | 10% cancer cell death |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 26524593 |