Primary information |
---|
OV_ID | OV_841 |
Virus Name | Herpes simplex virus |
Strain | HSV-G207 |
Virus type | DNA |
Virus family | Herpesviridae |
Modification in virus genome | Deletion mutant of both copies of gamma 34.5 gene |
Virus alone | Yes |
Virus in combination iwth drug/radiation | No |
Immune gene induction in virus genome | No |
Source of cell line | NA |
Origin of cell line | NA |
Cell line | NA |
Concentration of cell line | 0 |
In-vitro toxicity | NA |
Assay | NA |
In-vitro virus concentration | NA |
In-vitro result | NA |
Model organism | Male buffalo rat xenograft model of Morris hepatome McA-RH7777 cell |
In-vivo virus concentration | 1 × 10⸠pfu
|
In-vivo toxicity | NA |
In-vivo result | Complete reduction in tumor nodes |
Mode of delivery | Portal infusion |
Pathway induction | NA |
Immunogenic effect | NA |
Clinical trial | NA |
PMID | 10428757 |