Detailed description page of Selected OV_ID


OV_174 details
Primary information
OV_IDOV_174
Virus Name Herpes simplex virus
StrainrQNestin34.5
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant for both copies of gamma 34.5 gene and ICP6 gene, re-addition of 34.5 gene under nestin promoter
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineHuman glioblastoma astrocytoma cell line
Cell lineU251
Concentration of cell line0
In-vitro toxicityNA
AssayLDH cytotoxicity assay
In-vitro virus concentration3⁻⁴ MOI
In-vitro result40% cancer cell death
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID26524593