Browse result page of TopicalPdb


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ID1001SequenceACSSSPSKHCGNameTD1Nature of peptide or cargoTD1 enhances the transdermal delivery of macromoleculesAssayFranz diffusion cellsTissue permeabilitySignificant increase in permeability of the peptide can be seen by the addition of ATP.The amount of protein that permeated the skin was determined with ELISATissue SampleMale SD rats skin cellsPUBMED ID25269793
ID1020SequenceACSSSPSKHCGNameTDNNature of peptide or cargoTD-1 has been testified to enhanced insulin transdermal delivery through hair folliclesAssayConfocal Laser Scanning MicroscopyTissue permeabilitySignificant permeability of the peptide can be seen in confocal imagesTissue SampleMale SD rats skin cellsPUBMED ID23391375
ID1021SequenceACSSKKSKHCGNameTD-34Nature of peptide or cargoTD-1 has been testified to enhanced insulin transdermal delivery through hair folliclesAssayConfocal Laser Scanning MicroscopyTissue permeabilitySignificant permeability of the peptide can be seen in confocal imagesTissue SampleMale SD rats skin cellsPUBMED ID23391375
ID1022SequenceACSSSPSKHCGNameTD1Nature of peptide or cargoTD1 enhances the transdermal delivery of macromoleculesAssayFranz diffusion cells, immunity fluorescence techniquesTissue permeabilitySignificant permeability of the peptide can be seen. The amount of protein that permeated the skin was determined with immunity fluorescence techniquesTissue SampleMale SD rats skin cellsPUBMED ID23385091
ID1096SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTransdermal Delivery enhancerAssayFluorescence microscopy, Transmission electron microscopyTissue permeabilityPenetrates to the stratum corneum of rat footpad 15 min after topical application.Tissue SampleFootpad skin of ratsPUBMED ID22009459
ID1097SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTransdermal Delivery enhancerAssayFluorescence microscopy, Transmission electron microscopyTissue permeabilityCo-administered FAM-labeled siRNA gathered in the hair follicle 30 min after applicationTissue SampleBack skin of ratsPUBMED ID22009459
ID1098SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTransdermal Delivery enhancerAssayFluorescence microscopy, Transmission electron microscopyTissue permeabilityFAM-labeled siRNA and TD-1 topically co-administered penetrated from the stratum corneum to subcutaneous tissue 15 min after applicationTissue SampleFootpad skin of ratsPUBMED ID22009459
ID1099SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTransdermal Delivery enhancerAssayFluorescence microscopy, Transmission electron microscopyTissue permeabilityTD1 detected strongly from epithelial tissue to subcutaneous tissue 60 min after applicationTissue SampleFootpad skin of ratsPUBMED ID22009459
ID1100SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTransdermal Delivery enhancerAssayFluorescence microscopy, Transmission electron microscopyTissue permeabilityBoth FITC-labeled TD-1 and co-administered FAM-labeled siRNA were detected strongly from epithelial tissue to subcutaneous tissue 60 min after applicationTissue SampleFootpad skin of ratsPUBMED ID22009459
ID1101SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTransdermal Delivery enhancerAssayRT-PCRTissue permeabilityThe level of GADPH decreased 37 %Tissue SampleRat footpad skinPUBMED ID22009459
ID1102SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTransdermal Delivery enhancerAssayRT-PCRTissue permeabilityThe level of GADPH decreased 49 %Tissue SampleRat footpad skinPUBMED ID22009459
ID1103SequenceCGLHPAFQCNameTDA1Nature of peptide or cargoAnti-obesity treatment, Adipose tissue-targeting property and transdermal capacityAssayFranz cell systemTissue permeabilityAppearing frequency in the analyzed peptide pool (%) 28/280 (10)Tissue SampleAbdominal skin surface of male wistar ratsPUBMED ID21999821
ID1107SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTD1 enhances the transdermal delivery of macromoleculesAssayElectrical stimulation of the saphenous nerve at 4 Hz for 1 min in skin pretreated with vehicleTissue permeabilityThe maximum amount of PE (Plasma Extravasation) in the control side was 68 ± 3 PIUs compared to 46 ± 2 PIUs in BoNT-A + TD-1 pretreated skinTissue SampleDorsal surface of the rat hindpaw skinPUBMED ID20223589
ID1141SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTD1 enhances the transdermal delivery of macromoleculesAssayConfocal Laser Scanning Microscopy, Blood glucose measurementTissue permeabilitySignificant permeability of insulin could be seen in the confocal images, TD-1 without insulin had no effect on either blood glucose or serum insulin level, indicating that the glucose-lowering effect observed with TD 1 and insulin coadministration was due to the delivered exogenous insulin and not a physiological response elicited by TD-1Tissue SampleAbdominal skin of ratPUBMED ID16565728
ID1194SequenceMpr-YFQNCPrGNameDesmopressinNature of peptide or cargoIt is a peptide hormone that is used chiefly for treatment of enuresisAssayRadioimmunoassayTissue permeability10 ng/ml serum conc. of desmopressin after ~100 min of coated microneedle array applicationTissue SampleLateral skin areas of the thorax of hairless guinea pigsPUBMED ID15212882
ID1195SequenceMpr-YFQNCPrGNameDesmopressinNature of peptide or cargoIt is a peptide hormone that is used chiefly for treatment of enuresisAssayRadioimmunoassayTissue permeability1 ng/ml serum conc. of desmopressin after ~250 min of coated microneedle array applicationTissue SampleLateral skin areas of the thorax of hairless guinea pigsPUBMED ID15212882
ID1196SequenceMpr-YFQNCPrGNameDesmopressinNature of peptide or cargoIt is a peptide hormone that is used chiefly for treatment of enuresisAssayRadioimmunoassayTissue permeability0.8 ng/ml serum conc. of desmopressin after ~350 min of coated microneedle array applicationTissue SampleLateral skin areas of the thorax of hairless guinea pigsPUBMED ID15212882
ID1199SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 2.37 ± 0.94 µg h−1 cm−2 at 100% DCTissue SampleHuman cadaver skinPUBMED ID14757511
ID1200SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 9.87 ± 4.91 µg h−1 cm−2 at 75% pulsed DCTissue SampleHuman cadaver skinPUBMED ID14757511
ID1201SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 5.57 ± 2.27 µg h−1 cm−2 at 50% pulsed DCTissue SampleHuman cadaver skinPUBMED ID14757511
ID1202SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 1.21 ± 0.76 µg h−1 cm−2 at 75%+/25%− ACTissue SampleHuman cadaver skinPUBMED ID14757511
ID1203SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 0.006 ± 0.004 µg h−1 cm−2 at 50%+/50%− ACTissue SampleHuman cadaver skinPUBMED ID14757511
ID1204SequencepGlu-HWSY-D-2-Nal-LRPGNameNafarelinNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityNafarelin flux= 1.99 ± 2.04 µg h−1 cm−2 at 100% DCTissue SampleHuman cadaver skinPUBMED ID14757511
ID1205SequencepGlu-HWSY-D-2-Nal-LRPGNameNafarelinNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityNafarelin flux= 6.47 ± 0.87 µg h−1 cm−2 at 75% DCTissue SampleHuman cadaver skinPUBMED ID14757511
ID1206SequencepGlu-HWSY-D-2-Nal-LRPGNameNafarelinNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityNafarelin flux= 0.96 ± 0.79 µg h−1 cm−2 at 50% pulsed DCTissue SampleHuman cadaver skinPUBMED ID14757511
ID1207SequencepGlu-HWSY-D-2-Nal-LRPGNameNafarelinNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityNafarelin flux= 3.33 ± 1.04 µg h−1 cm−2 at 75%+/25%- ACTissue SampleHuman cadaver skinPUBMED ID14757511
ID1208SequencepGlu-HWSY-D-2-Nal-LRPGNameNafarelinNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityNafarelin flux= 0.15 ± 0.09 µg h−1 cm−2 at 50%+/50%- ACTissue SampleHuman cadaver skinPUBMED ID14757511
ID1209SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 12.39 ± 5.32 µg h−1 cm−2 at 75% pulsed DC (500 Hz)Tissue SampleEpidermis of human cadaver skinPUBMED ID14757511
ID1210SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 5.97 ± 3.20 µg h−1 cm−2 at 50% pulsed DC (500 Hz)Tissue SampleEpidermis of human cadaver skinPUBMED ID14757511
ID1211SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux=9.07 ± 4.28 µg h−1 cm−2 at 25% pulsed DC (500 Hz)Tissue SampleEpidermis of human cadaver skinPUBMED ID14757511
ID1212SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 8.70±3.56 µg h−1 cm−2 at 75% pulsed DC (5 Hz)Tissue SampleEpidermis of human cadaver skinPUBMED ID14757511
ID1213SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 7.31±1.94 µg h−1 cm−2 at 50% pulsed DC (5 Hz)Tissue SampleEpidermis of human cadaver skinPUBMED ID14757511
ID1214SequencepGlu-HWSYGLRPGNameLHRHNature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current.AssayHPLCTissue permeabilityLHRH flux= 9.35±1.98 µg h−1 cm−2 at 25% pulsed DC (5 Hz)Tissue SampleEpidermis of human cadaver skinPUBMED ID14757511
ID1218SequenceI/V-CLe-I/V-K-orn-I/V-fHdNNameBacitracinNature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids.AssayFluorescein-labeled bacitracin and confocal microscopy, HPLCTissue permeabilityBacitracin Cumulative Amount(µg/cm2)=42.3±3.8Tissue SampleHuman epidermis from abdominal sites of Caucasian femalesPUBMED ID12712421
ID1219SequenceI/V-CLe-I/V-K-orn-I/V-fHdNNameBacitracinNature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids.AssayFluorescein-labeled bacitracin and confocal microscopy, HPLCTissue permeabilityBacitracin Cumulative Amount(µg/cm2)=80.2±4.7Tissue SampleHuman epidermis from abdominal sites of Caucasian femalesPUBMED ID12712421
ID1220SequenceI/V-CLe-I/V-K-orn-I/V-fHdNNameBacitracinNature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids.AssayFluorescein-labeled bacitracin and confocal microscopy, HPLCTissue permeabilityBacitracin Cumulative Amount(µg/cm2)=44.1±4Tissue SampleHuman epidermis from abdominal sites of Caucasian femalesPUBMED ID12712421
ID1221SequenceI/V-CLe-I/V-K-orn-I/V-fHdNNameBacitracinNature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids.AssayFluorescein-labeled bacitracin and confocal microscopy, HPLCTissue permeabilityBacitracin Cumulative Amount(µg/cm2)=82.1±4.4Tissue SampleHuman epidermis from abdominal sites of Caucasian femalesPUBMED ID12712421
ID1222SequenceI/V-CLe-I/V-K-orn-I/V-fHdNNameBacitracinNature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids.AssayFluorescein-labeled bacitracin and confocal microscopy, HPLCTissue permeabilityBacitracin Cumulative Amount(µg/cm2)=52.8±4.4Tissue SampleHuman epidermis from abdominal sites of Caucasian femalesPUBMED ID12712421
ID1223SequenceI/V-CLe-I/V-K-orn-I/V-fHdNNameBacitracinNature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids.AssayFluorescein-labeled bacitracin and confocal microscopy, HPLCTissue permeabilityBacitracin Cumulative Amount(µg/cm2)=95±2.9Tissue SampleHuman epidermis from abdominal sites of Caucasian femalesPUBMED ID12712421
ID1224Sequence(Chain A: GIVEQCCTSICSLYQLENYCN) (Chain B: FVNQHLCGSHLVEALYLVCGERGFFYTPKT)NameInsulin in poloxamer gel 407Nature of peptide or cargoIt is used in the treatment diabetes mellitus and has immense therapeutic and commercial importanceAssayFranz diffusion cells, RadioimuunoassayTissue permeabilitySkin permeation parameters of insulin from poloxamer 407 gel using menthone enhancer, Lag time (h)=1.20 (0.02) , Flux (µg/cm2 /h)=5.57 (0.13), Cumulative amount permeated (µg)=210.78 (2.64), Skin affinity=10.57 (0.38), (P<0.05), all values are n=3Tissue SampleFemale Sprague–Dawley rat skinPUBMED ID12695068
ID1225Sequence(Chain A: GIVEQCCTSICSLYQLENYCN)
(Chain B: FVNQHLCGSHLVEALYLVCGERGFFYTPKT)
NameInsulin in poloxamer gel 408Nature of peptide or cargoIt is used in the treatment diabetes mellitus and has immense therapeutic and commercial importanceAssayFranz diffusion cells, RadioimuunoassayTissue permeabilitySkin permeation parameters of insulin from poloxamer 407 gel using linoleic acid enhancer, Lag time (h)=0.65 (0.49) , Flux (µg/cm2 /h)=8.08 (0.20), Cumulative amount permeated (µg)=244.38 (30.21), Skin affinity=5.28 (2.37), (P<0.05), all values are n=3Tissue SampleFemale Sprague–Dawley rat skinPUBMED ID12695068
ID1245SequencepGlu-HPNameThyrotropin-releasing hormone (TRH)Nature of peptide or cargoIt is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND)AssayRadioimmunoassay and Liquid Scintillation TechniqueTissue permeabilityPermeability coefficient (Kp)= 18.4*105 cm/h, Cumulative amount= 24.9± 1.7 µg/cm2, Enhancement factor (EF) =3.4Tissue SampleHuman epidermal membranePUBMED ID10205635
ID1246SequencepGlu-HPNameThyrotropin-releasing hormone (TRH)Nature of peptide or cargoIt is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND)AssayRadioimmunoassay and Liquid Scintillation TechniqueTissue permeabilityPermeability coefficient (Kp)= 16.6*105 cm/h, Cumulative amount= 18.5± 2.1 µg/cm2, Enhancement factor (EF) =3.1Tissue SampleHuman epidermal membranePUBMED ID10205635
ID1247SequencepGlu-HPNameThyrotropin-releasing hormone (TRH)Nature of peptide or cargoIt is a tripeptide that used in the treatment of brain and spinal cord injury and certain CNS disorders, including Alzheimer’s disease and motor neuron disease (MND)AssayRadioimmunoassay and Liquid Scintillation TechniqueTissue permeabilityPermeability coefficient (Kp)= 5.4*105 cm/h, Cumulative amount= 7.8± 1.7 µg/cm2, Enhancement factor (EF) =0Tissue SampleHuman epidermal membranePUBMED ID10205635
ID1248SequencepGlu-3-methyl-HPNameM-TRHNature of peptide or cargoAnalogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide.AssayLiquid Scintillation TechniqueTissue permeabilityPermeability coefficient (Kp)= 32.0*105 cm/h, Cumulative amount= 41.5±4.9 µg/cm2, Enhancement factor (EF) =4.7Tissue SampleHuman epidermal membranePUBMED ID10205635
ID1249SequencepGlu-3-methyl-HPNameM-TRHNature of peptide or cargoAnalogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide.AssayLiquid Scintillation TechniqueTissue permeabilityPermeability coefficient (Kp)=20.2*105 cm/h, Cumulative amount= 20.4± 3.6µg/cm2, Enhancement factor (EF) =3.0Tissue SampleHuman epidermal membranePUBMED ID10205635
ID1250SequencepGlu-3-methyl-HPNameM-TRHNature of peptide or cargoAnalogue of TRH i.e. M-TRH is a potent analogue and stimulates the release of TSH from the pituitary seven to eight times that of the parental tripeptide.AssayLiquid Scintillation TechniqueTissue permeabilityPermeability coefficient (Kp)= 6.8*105 cm/h, Cumulative amount= 8.6± 1.0 µg/cm2, Enhancement factor (EF) =0Tissue SampleHuman epidermal membranePUBMED ID10205635
ID1265SequenceSNLST-Asu-VLGKLSQELH
KLQTYPRTDVGAGTP
NameElcatoninNature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorptionAssayCalcium C-Test Wako kit, Ames method, Alkaline Phospha K-Test and ANOVATissue permeabilityParameters studied: Ca(mg/dl)- 8.83±0.20/8.94±0.17(control), P(mg/dl)- 5.32±0.35/5.58±0.55(control) and Alkaline phosphatase- 23.69±1.16/18.83±0.75(control)Tissue SampleAbdominal skin of female wistar ratsPUBMED ID8268857
ID1266SequenceSNLST-Asu-VLGKLSQELH
KLQTYPRTDVGAGTP
NameElcatoninNature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorptionAssayCalcium C-Test Wako kit, Ames method, Alkaline Phospha K-Test and ANOVATissue permeabilityParameters studied: Ca(mg/dl)- 8.80±0.27/8.94±0.17(control), P(mg/dl)- 5.22±0.36/5.58±0.55(control) and Alkaline phosphatase- 22.21±4.01/18.83±0.75(control)Tissue SampleAbdominal skin of female wistar ratsPUBMED ID8268857
ID1335SequenceSNLST-Asu-VLGKLSQEL
HKLQTYPRTDVGAGTP
NameElcatoninNature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorptionAssayo-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysisTissue permeabilityArea under the curve(mg.h/dl)=30.99±11.75 , Area under the first moment curve(mg.h2/dl)=371.41±159.80 , The mean residence time(h)=12.06±1.99 , Apparent bioavailability(%)=2.68.Tissue SampleStratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat)PUBMED ID2054872