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Details of TopicalPdb ID 1218

PRIMARY INFORMATION
ID1218
PMID12712421
Year2002
SequenceI/V-CLe-I/V-K-orn-I/V-fHdN
NameBacitracin
Length12
N-Terminal ModificationThiazoline ring
C-Terminal ModificationFree
Linear/ CyclicCyclic
ChiralityMix
Chemical ModificationCondensed aminoacids 1 and 2 forming thiazoline ring, orn=D-Ornithine, I/V= Ile or Val
Origin of PeptideProduced as a mixture of closely related congeners by nonribosomal pathway catalyzed by large clusters of peptide and ketide synthetases and peptide/ketide “hybrid” synthetases, respectively
Nature of Peptide/CargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids.
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFluorescein-labeled bacitracin and confocal microscopy, HPLC
Enhancer1.75 µL phosphatidylcholine (PC)-liposomes
Properties of enhancerNot mentioned
ConcentrationAfter 12 h from liposome application, 75µL of bacitracin–FITC 100 µM phosphate buffer is applied
Incubation time24 Hours
Tissue permeability (value with units)Bacitracin Cumulative Amount(µg/cm2)=42.3±3.8
Tissue SampleHuman epidermis from abdominal sites of Caucasian females
Ex vivo/In vivo/In vitroex vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.