Details of TopicalPdb ID 1335
| ID | 1335 | |
| PMID | 2054872 | |
| Year | 1991 | |
| Sequence | SNLST-Asu-VLGKLSQEL HKLQTYPRTDVGAGTP | |
| Name | Elcatonin | |
| Length | 31 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Amidation | |
| Linear/ Cyclic | Cyclic (bond between Ser1 and Asu6) | |
| Chirality | L | |
| Chemical Modification | Asu=Aminosuberic Acid | |
| Origin of Peptide | Synthetic analogue of eel calcitonin in which disulfide bridge between first and seventh amino acids is replaced by -CH2CH2- bridge | |
| Nature of Peptide/Cargo | It stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | |
| Mechanism | Not mentioned | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | o-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis | |
| Enhancer | n-octyl-β-D-glucoside=1.5g, Bestatin=5.0mg | |
| Properties of enhancer | Not mentioned | |
| Concentration | Carbopol 934-2.0g, Elcatonin-25.0mg, Propylene glycol-10.0g, Gentamycin sol.-2.0g, Purified water ad.-100.0g and enhancers | |
| Incubation time | 24 Hours | |
| Tissue permeability (value with units) | Area under the curve(mg.h/dl)=30.99±11.75 , Area under the first moment curve(mg.h2/dl)=371.41±159.80 , The mean residence time(h)=12.06±1.99 , Apparent bioavailability(%)=2.68. | |
| Tissue Sample | Stratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat) | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
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| SMILES | N.A. | |