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Details of TopicalPdb ID 1224

PRIMARY INFORMATION
ID1224
PMID12695068
Year2003
Sequence(Chain A: GIVEQCCTSICSLYQLENYCN) (Chain B: FVNQHLCGSHLVEALYLVCGERGFFYTPKT)
NameInsulin in poloxamer gel 407
Length51
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicCyclic (Chain A: C6-C11)(Chain A:C7-Chain B:C7) (Chain A:C20-Chain B:C19)
ChiralityL
Chemical ModificationNone
Origin of PeptidePolypeptide
Nature of Peptide/CargoIt is used in the treatment diabetes mellitus and has immense therapeutic and commercial importance
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayFranz diffusion cells, Radioimuunoassay
EnhancerMenthone
Properties of enhancerNot mentioned
Concentration500 µl of gel formulation with 500 µl of menthone (5% v / v)
Incubation time2 h
Tissue permeability (value with units)Skin permeation parameters of insulin from poloxamer 407 gel using menthone enhancer, Lag time (h)=1.20 (0.02) , Flux (µg/cm2 /h)=5.57 (0.13), Cumulative amount permeated (µg)=210.78 (2.64), Skin affinity=10.57 (0.38), (P<0.05), all values are n=3
Tissue SampleFemale Sprague–Dawley rat skin
Ex vivo/In vivo/In vitroex vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.