Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID1259 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityAlgesic response: ~15(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. Maximal painful response was attained 1-2 minutes after drug administration and faded after 5 minutes. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1260 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityAlgesic response: ~22(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. Maximal painful response was attained 1-2 minutes after drug administration and faded after 5 minutes. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1261 | SequenceKRPPGFSPFR | NameKallidin | Nature of peptide or cargoPotent inflammatory mediators produced during acute and chronic inflammation.They are released at high nanomolar concentrations into the tear-film of ocular allergic patients. | AssayPainful sensation assessed in a visual analogue scale(VAS) | Tissue permeabilityPain response obtained in nostrils after capsaicin vehicle pretreatment: ~15.3(VAS value), the intensity of the sensation experienced with a single dose of capsaicin was considered the maximum value (i.e. 100) on the analogue scale, and all successive responses were scored in relation to this value. | Tissue SampleSolution was applied by a micropipette into the nostril of thirty-four healthy volunteers of either sex | PUBMED ID8443036 |
| ID1265 | SequenceSNLST-Asu-VLGKLSQELH KLQTYPRTDVGAGTP | NameElcatonin | Nature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | AssayCalcium C-Test Wako kit, Ames method, Alkaline Phospha K-Test and ANOVA | Tissue permeabilityParameters studied: Ca(mg/dl)- 8.83±0.20/8.94±0.17(control), P(mg/dl)- 5.32±0.35/5.58±0.55(control) and Alkaline phosphatase- 23.69±1.16/18.83±0.75(control) | Tissue SampleAbdominal skin of female wistar rats | PUBMED ID8268857 |
| ID1266 | SequenceSNLST-Asu-VLGKLSQELH KLQTYPRTDVGAGTP | NameElcatonin | Nature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | AssayCalcium C-Test Wako kit, Ames method, Alkaline Phospha K-Test and ANOVA | Tissue permeabilityParameters studied: Ca(mg/dl)- 8.80±0.27/8.94±0.17(control), P(mg/dl)- 5.22±0.36/5.58±0.55(control) and Alkaline phosphatase- 22.21±4.01/18.83±0.75(control) | Tissue SampleAbdominal skin of female wistar rats | PUBMED ID8268857 |
| ID1267 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of number of cups | Tissue permeabilityMeasurement of number of cups: Control:1.5 , Test:3 | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1268 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of number of cups | Tissue permeabilityMeasurement of number of cups: Control:4 , Test:9 | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1269 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of number of cups | Tissue permeabilityMeasurement of number of cups: Control:4.5 , Test:7.5 | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1270 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of number of cups | Tissue permeabilityMeasurement of number of cups: Control:7 , Test:15 | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1271 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of E2(Erection) | Tissue permeabilityMeasurement of E2(Erection): Control:15 , Test:26 | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1272 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of E2(Erection) | Tissue permeabilityMeasurement of E2(Erection): Control:4 , Test:11 | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1273 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of E2(Erection) | Tissue permeabilityMeasurement of E2(Erection): Control:6 , Test:12 | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1274 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of E2(Erection) | Tissue permeabilityMeasurement of E2(Erection): Control:11 , Test:24 | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1275 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first cup | Tissue permeabilityMeasurement of latency of first cup: Control:44 minutes , Test:38 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1276 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first cup | Tissue permeabilityMeasurement of latency of first cup: Control:25.5 minutes , Test:19 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1277 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first cup | Tissue permeabilityMeasurement of latency of first cup: Control:39 minutes , Test:32 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1278 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first cup | Tissue permeabilityMeasurement of latency of first cup: Control:23 minutes , Test:15 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1279 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first E2(Erection) | Tissue permeabilityMeasurement of latency of first E2(Erection): Control:29 minutes , Test:31 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1280 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first E2(Erection) | Tissue permeabilityMeasurement of latency of first E2(Erection): Control:32 minutes , Test:16 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1281 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first E2(Erection) | Tissue permeabilityMeasurement of latency of first E2(Erection): Control:9 minutes , Test:3 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1282 | SequenceHSDAVFTDNYTRLR KQMAVKKYLNSILN | NameStearyl-VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first E2(Erection) | Tissue permeabilityMeasurement of latency of first E2(Erection): Control:3.5 minutes , Test:2 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1283 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of number of cups | Tissue permeabilityMeasurement of number of first cup: Control:7 minutes , Test:20.2 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1284 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of E2(Erection) | Tissue permeabilityMeasurement of number of first E2(Erection): Control:11 minutes , Test:35 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1285 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first cup | Tissue permeabilityMeasurement of latency of first cup: Control:23 minutes , Test:10 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1286 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first E2(Erection) | Tissue permeabilityMeasurement of latency of first E2(Erection): Control:3.5 minutes , Test:1.9 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1287 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay | Tissue permeabilityTime course of distribution of radioactively labelled peptide: Control:6 minutes , Test:20 minutes | Tissue SampleThree-month-old diabetic rats | PUBMED ID8156912 |
| ID1288 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay | Tissue permeabilityTime course of distribution of radioactively labelled peptide:Control:5.5 minutes , Test:21.5 minutes | Tissue SampleSpontaneous high blood pressure rats(SHR) | PUBMED ID8156912 |
| ID1289 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 57% (32 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1290 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 55% (23 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1291 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 54% (21 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1292 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 56% (20 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1293 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 58% (16 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1294 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 61% (14 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1325 | SequenceYGGFL | NameLeu-enkephalin | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability0.01% GFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1326 | SequenceYGGFL | NameLeu-enkephalin | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability0.03% GGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1327 | SequenceYGGFL | NameLeu-enkephalin | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability0.035% FL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1328 | SequenceYGGFL | NameLeu-enkephalin | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability0.1% YGGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1329 | SequenceYaGFL | NameYGGFL analogue | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability1% aGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1330 | SequenceYaGFL | NameYGGFL analogue | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability18.5% YaGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1331 | SequenceYaGFL | NameYGGFL analogue | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability3.75% aGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1332 | SequenceYaGFL | NameYGGFL analogue | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability10.75% YaGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1333 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7)-a-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays | AssayFrog Skin Bioassay | Tissue permeabilityHead and neck(85.7%), Trunk(8.7%),Leg(25%) | Tissue SampleStratum corneum of human skin samples (obtained from freshly excised surgical specimens) | PUBMED ID2155969 |
| ID1334 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7)-a-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays | AssayRadioimmunoassay | Tissue permeabilityHead and neck(78.6%), Trunk(8.8%),Leg(33.3%) | Tissue SampleStratum corneum of human skin samples (obtained from freshly excised surgical specimens) | PUBMED ID2155969 |
| ID1335 | SequenceSNLST-Asu-VLGKLSQEL HKLQTYPRTDVGAGTP | NameElcatonin | Nature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | Assayo-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis | Tissue permeabilityArea under the curve(mg.h/dl)=30.99±11.75 , Area under the first moment curve(mg.h2/dl)=371.41±159.80 , The mean residence time(h)=12.06±1.99 , Apparent bioavailability(%)=2.68. | Tissue SampleStratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat) | PUBMED ID2054872 |
| ID1336 | SequenceSNLST-Asu-VLGKLSQEL HKLQTYPRTDVGAGTP | NameElcatonin | Nature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | Assayo-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis | Tissue permeabilityArea under the curve(mg.h/dl)=46.25±19.25 , Area under the first moment curve(mg.h2/dl)=623.71±233.74 , The mean residence time(h)=13.81±2.36 , Apparent bioavailability(%)=3.99. | Tissue SampleStratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat) | PUBMED ID2054872 |
| ID1337 | SequenceSNLST-Asu-VLGKLSQEL HKLQTYPRTDVGAGTP | NameElcatonin | Nature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | Assayo-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis | Tissue permeabilityArea under the curve(mg.h/dl)=36.13±21.93 , Area under the first moment curve(mg.h2/dl)=445.49±248.06 , The mean residence time(h)=12.83±1.68 , Apparent bioavailability(%)=3.12. | Tissue SampleStratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat) | PUBMED ID2054872 |
| ID1338 | SequenceSNLST-Asu-VLGKLSQEL HKLQTYPRTDVGAGTP | NameElcatonin | Nature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | Assayo-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis | Tissue permeabilityArea under the curve(mg.h/dl)=17.25±10.07 , Area under the first moment curve(mg.h2/dl)=271.52±106.34 , The mean residence time(h)=18.16±6.19 , Apparent bioavailability(%)=1.49. | Tissue SampleStratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat) | PUBMED ID2054872 |
| ID1339 | SequenceSNLST-Asu-VLGKLSQEL HKLQTYPRTDVGAGTP | NameElcatonin | Nature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | Assayo-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis | Tissue permeabilityArea under the curve(mg.h/dl)=53.50±14.96 , Area under the first moment curve(mg.h2/dl)=752.04±298.40 , The mean residence time(h)=13.66±3.46 , Apparent bioavailability(%)=4.62. | Tissue SampleStratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat) | PUBMED ID2054872 |
| ID1340 | SequenceSNLST-Asu-VLGKLSQEL HKLQTYPRTDVGAGTP | NameElcatonin | Nature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | Assayo-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis | Tissue permeabilityArea under the curve(mg.h/dl)=31.97±17.89 , Area under the first moment curve(mg.h2/dl)=505.37±238.24 , The mean residence time(h)=16.32±2.35 , Apparent bioavailability(%)=2.76. | Tissue SampleStratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat) | PUBMED ID2054872 |
| ID1341 | SequenceSNLST-Asu-VLGKLSQEL HKLQTYPRTDVGAGTP | NameElcatonin | Nature of peptide or cargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption | Assayo-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis | Tissue permeabilityArea under the curve(mg.h/dl)=40.85±20.01 , Area under the first moment curve(mg.h2/dl)=513.32±292.53 , The mean residence time(h)=12.34±2.37 , Apparent bioavailability(%)=3.53. | Tissue SampleStratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat) | PUBMED ID2054872 |