Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1326

PRIMARY INFORMATION
ID1326
PMID2293206
Year1990
SequenceYGGFL
NameLeu-enkephalin
Length5
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideType of enkephalin
Nature of Peptide/CargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayHPLC
Enhancer10 mM n-decylmethyl sulfoxide (NDMS) at 37°C at pH 5
Properties of enhancern-decylmethyl sulfoxide, a non ionic surfactant, increased the permeabilities of several compounds upto 0.1 cm/hr
Concentration200µg/ml
Incubation time26 hours
Tissue permeability (value with units)0.03% GGFL of the parent peptide
Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N
[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C=O