| PRIMARY INFORMATION |
|---|
| ID | 1337 |
| PMID | 2054872 |
| Year | 1991 |
| Sequence | SNLST-Asu-VLGKLSQEL
HKLQTYPRTDVGAGTP |
| Name | Elcatonin |
| Length | 31 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Amidation |
| Linear/ Cyclic | Cyclic (bond between Ser1 and Asu6) |
| Chirality | L |
| Chemical Modification | Asu=Aminosuberic Acid |
| Origin of Peptide | Synthetic analogue of eel calcitonin in which disulfide bridge between first and seventh amino acids is replaced by -CH2CH2- bridge |
| Nature of Peptide/Cargo | It stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption |
| Mechanism | Not mentioned |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | o-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis |
| Enhancer | n-octyl-β-D-thioglucoside=1.5g, Bestatin=5.0mg |
| Properties of enhancer | Not mentioned |
| Concentration | Carbopol 934-2.0g, Elcatonin-25.0mg, Propylene glycol-10.0g, Gentamycin sol.-2.0g, Purified water ad.-100.0g and enhancers |
| Incubation time | 24 Hours |
| Tissue permeability (value with units) | Area under the curve(mg.h/dl)=36.13±21.93 , Area under the first moment curve(mg.h2/dl)=445.49±248.06 , The mean residence time(h)=12.83±1.68 , Apparent bioavailability(%)=3.12. |
| Tissue Sample | Stratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat) |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
