| PRIMARY INFORMATION |
|---|
| ID | 1333 |
| PMID | 2155969 |
| Year | 1990 |
| Sequence | SYS-Nle-EHfRWGKPV |
| Name | (Nle4, D-Phe7)-a-MSH |
| Length | 13 |
| N-Terminal Modification | Acetylation |
| C-Terminal Modification | Amidation |
| Linear/ Cyclic | Linear |
| Chirality | Mix |
| Chemical Modification | Nle=Norleucine |
| Origin of Peptide | Derived from α-MSH |
| Nature of Peptide/Cargo | The analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays |
| Mechanism | It causes follicular melanogenesis,the analogue caused a shift of follicular melanocytes from pheomelanogenesis (yellow melanin) to eumelanogenesis (dark brown/black melanin) in hair follicles. |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Frog Skin Bioassay |
| Enhancer | None |
| Properties of enhancer | Not applicable |
| Concentration | 100µ/100 mm2 for the smaller-sized permeation cell and 200µ/230 mm2 for the large-sized cell |
| Incubation time | 24 hours |
| Tissue permeability (value with units) | Head and neck(85.7%), Trunk(8.7%),Leg(25%) |
| Tissue Sample | Stratum corneum of human skin samples (obtained from freshly excised surgical specimens) |
| Ex vivo/In vivo/In vitro | in vitro |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
