Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0007	ER-112022 Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Chinese Hamster	Chinese hamster ovary fibroblasts	NA	NA	NA	NA	NA	NA	2473841	1989	NA
PRRID_0007	ER-112022 Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Synthetic	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Chinese Hamster	Chinese hamster ovary fibroblasts	NA	NA	NA	NA	NA	NA	2473841	1989	NA
PRRID_0039	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	small chemical derivatives (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	guanosine analogue	Synthetic	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	7743561	1995	NA
PRRID_0039	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	small chemical derivatives (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	guanosine analogue	Synthetic	Immunostimulant	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	7743561	1995	NA
PRRID_0040	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	small chemical derivatives (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	guanosine analogue	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	7743561	1995	NA
PRRID_0040	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	small chemical derivatives (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	guanosine analogue	Synthetic	Immunostimulant	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	7743561	1995	NA
PRRID_0053	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0053	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0054	N-Pam-S-Lau2CSK4 Click for more detail	Synthetic (others)	NA	NA	Lipopeptides	Synthetic	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0054	N-Pam-S-Lau2CSK4 Click for more detail	Synthetic (others)	NA	NA	Lipopeptides	Synthetic	Immunostimulant	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	ELISA	8549669	1996	NA
PRRID_0074	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycan recognition by TLR 2 leads to the activation of NF-KB, which leads to the secretion of proinflammatory cytokines.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Fibroblasts	LRR	O60603.fasta	O60603	784	TLR2 is responsible for recognzing the cell wall components of the gram-positive bacteria and induces the respective immune response.	EMSA	10384090	1999	Pubchem Assay
PRRID_0074	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycan recognition by TLR 2 leads to the activation of NF-KB, which leads to the secretion of proinflammatory cytokines.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Fibroblasts	LRR	O60603.fasta	O60603	784	TLR2 is responsible for recognzing the cell wall components of the gram-positive bacteria and induces the respective immune response.	EMSA	10384090	1999	Pubchem Assay
PRRID_0075	pneumolysin Click for more detail	S. pneumoniae (Bacteria)	MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND	471	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	ytokine induction is mediated through NF-kappaB activation	NA	10411278	1999	Pubchem Assay
PRRID_0075	pneumolysin Click for more detail	S. pneumoniae (Bacteria)	MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND	471	NA	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	ytokine induction is mediated through NF-kappaB activation	NA	10411278	1999	Pubchem Assay
PRRID_0081	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	NA	Q9NR96.fasta	Q9NR96	1032	induce type I interferons (IFN) and other cytokines production.	NA	11130078	2000	Pubchem Assay
PRRID_0081	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	NA	Q9NR96.fasta	Q9NR96	1032	induce type I interferons (IFN) and other cytokines production.	NA	11130078	2000	Pubchem Assay
PRRID_0082	ER-112022 Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Synthetic	It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Raw 264.7 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has the role in immuno inflammation.	ELISA	11032843	2000	Pubchem Assay
PRRID_0082	ER-112022 Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Synthetic	It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Raw 264.7 cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has the role in immuno inflammation.	ELISA	11032843	2000	Pubchem Assay
PRRID_0083	ER-112022 Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Synthetic	It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	U373 human astrocytoma cells	LRR	O00206.fasta	O00206	839	It has the role in immuno inflammation.	ELISA	11032843	2000	Pubchem Assay
PRRID_0083	ER-112022 Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Synthetic	It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	U373 human astrocytoma cells	LRR	O00206.fasta	O00206	839	It has the role in immuno inflammation.	ELISA	11032843	2000	Pubchem Assay
PRRID_0084	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	immunostimulantt	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	induction of TNF-alpha and NO formation	NA	10623794	2000	Pubchem Assay
PRRID_0084	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	immunostimulantt	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	NA	O00206.fasta	O00206	839	induction of TNF-alpha and NO formation	NA	10623794	2000	Pubchem Assay
PRRID_0086	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	10679411	2000	NA
PRRID_0086	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	elicit innate immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	induce type I interferons (IFN) and other cytokines production.	NA	10679411	2000	NA
PRRID_0087	Lipoteichoic Acid (LTA) Click for more detail	Gram-positive bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Macrophages	NA	Q9Y2C9.fasta	Q9Y2C9	796	production of pro-inflammatory cytokines	ELISA	11095740	2000	Pubchem Assay
PRRID_0087	Lipoteichoic Acid (LTA) Click for more detail	Gram-positive bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Macrophages	NA	Q9Y2C9.fasta	Q9Y2C9	796	production of pro-inflammatory cytokines	ELISA	11095740	2000	Pubchem Assay
PRRID_0088	Lipoteichoic Acid (LTA) Click for more detail	Gram-positive bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	production of pro-inflammatory cytokines	ELISA	11095740	2000	Pubchem Assay
PRRID_0088	Lipoteichoic Acid (LTA) Click for more detail	Gram-positive bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	production of pro-inflammatory cytokines	ELISA	11095740	2000	Pubchem Assay
PRRID_0090	Not Determined Click for more detail	herpes simplex virus (virus)	NA	NA	Others	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUN7.fasta	Q9QUN7	784	NA	NA	11062499	2000	Pubchem Assay
PRRID_0090	Not Determined Click for more detail	herpes simplex virus (virus)	NA	NA	Others	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	NA	Q9QUN7.fasta	Q9QUN7	784	NA	NA	11062499	2000	Pubchem Assay
PRRID_0097	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0097	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0098	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0098	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0099	dsRNA Click for more detail	Type I Lang mammalian reovirus (virus)	NA	NA	Nucleic Acid	Natural	It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	(HEK293 t cells)	NA	O15455.fasta	O15455	904	IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.	EMSA	11607032	2001	Pubchem Assay
PRRID_0099	dsRNA Click for more detail	Type I Lang mammalian reovirus (virus)	NA	NA	Nucleic Acid	Natural	It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	(HEK293 t cells)	NA	O15455.fasta	O15455	904	IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.	EMSA	11607032	2001	Pubchem Assay
PRRID_0100	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	NA	Q9JLF7.fasta	Q9JLF7	859	NA	tandem mass spectrometry	0	2001	Pubchem Assay
PRRID_0100	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	NA	Q9JLF7.fasta	Q9JLF7	859	NA	tandem mass spectrometry	0	2001	Pubchem Assay
PRRID_0101	Heat-shock proteins 60 Click for more detail	Human (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	HSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Fibroblasts	LRR	O60603.fasta	O60603	784	It has the role in immuno inflammation.	Luciferase reporter assay	11402040	2001	Pubchem Assay
PRRID_0101	Heat-shock proteins 60 Click for more detail	Human (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	HSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK).	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Fibroblasts	LRR	O60603.fasta	O60603	784	It has the role in immuno inflammation.	Luciferase reporter assay	11402040	2001	Pubchem Assay
PRRID_0102	Heat-shock proteins 60 Click for more detail	Human (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	HSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK).	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Fibroblasts	LRR	O00206.fasta	O00206	839	It has the role in immuno inflammation.	Luciferase reporter assay	11402040	2001	Pubchem Assay
PRRID_0102	Heat-shock proteins 60 Click for more detail	Human (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	HSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK).	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Fibroblasts	LRR	O00206.fasta	O00206	839	It has the role in immuno inflammation.	Luciferase reporter assay	11402040	2001	Pubchem Assay
PRRID_0105	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0105	MALP-2 (macrophage-activating lipopeptide 2) Click for more detail	Mycoplasma (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	Immunostimulant	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	11431423	2001	NA
PRRID_0111	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	(HEK293 t cells)	NA	O15455.fasta	O15455	904	IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.	EMSA	11607032	2001	Pubchem Assay
PRRID_0111	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	(HEK293 t cells)	NA	O15455.fasta	O15455	904	IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.	EMSA	11607032	2001	Pubchem Assay
PRRID_0115	beta-defensin Click for more detail	Endogenous (others)	MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS	69	Peptide	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12411706	2002	NA
PRRID_0115	beta-defensin Click for more detail	Endogenous (others)	MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS	69	Peptide	Natural	Immunostimulant	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12411706	2002	NA
PRRID_0116	Fragments of heparan sulphate Click for more detail	Host (Endogenous) (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Proteoglycan	Natural	Heparan sulfate induces nuclear translocation of NF-kappaB.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Bone-Marrow culture	NA	Q9QUK6.fasta	Q9QUK6	835	TLR4 plays the role in the activation and maturation of dendritic cells, thus suggesting that vertebrate TLR monitor perturbations to the well-being of tissues.	EMSA	11994480	2002	Pubchem Assay
PRRID_0116	Fragments of heparan sulphate Click for more detail	Host (Endogenous) (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Proteoglycan	Natural	Heparan sulfate induces nuclear translocation of NF-kappaB.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Bone-Marrow culture	NA	Q9QUK6.fasta	Q9QUK6	835	TLR4 plays the role in the activation and maturation of dendritic cells, thus suggesting that vertebrate TLR monitor perturbations to the well-being of tissues.	EMSA	11994480	2002	Pubchem Assay
PRRID_0119	GP96 Click for more detail	Human (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	It results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces I	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Embryonic Kidney Fibroblasts‚Äî 293T	LRR	O60603.fasta	O60603	784	Gp96 has the ability to induce specific immune responses against tumors and pathogens	Luciferase reporter assay	11912201	2002	Pubchem Assay
PRRID_0119	GP96 Click for more detail	Human (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	It results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces I	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Embryonic Kidney Fibroblasts‚Äî 293T	LRR	O60603.fasta	O60603	784	Gp96 has the ability to induce specific immune responses against tumors and pathogens	Luciferase reporter assay	11912201	2002	Pubchem Assay
PRRID_0120	GP96 Click for more detail	Human (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	It results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces I	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Embryonic Kidney Fibroblasts‚Äî 293T	LRR	O00206.fasta	O00206	839	Gp96 has the ability to induce specific immune responses against tumors and pathogens	Luciferase reporter assay	11912201	2002	Pubchem Assay
PRRID_0120	GP96 Click for more detail	Human (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	It results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces I	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Embryonic Kidney Fibroblasts‚Äî 293T	LRR	O00206.fasta	O00206	839	Gp96 has the ability to induce specific immune responses against tumors and pathogens	Luciferase reporter assay	11912201	2002	Pubchem Assay
PRRID_0121	Gp96 Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	NA	NA	11842086	2002	Pubchem Assay
PRRID_0121	Gp96 Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	NA	NA	11842086	2002	Pubchem Assay
PRRID_0122	Gp96 Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	NA	NA	11842086	2002	Pubchem Assay
PRRID_0122	Gp96 Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	NA	NA	11842086	2002	Pubchem Assay
PRRID_0123	Heat-shock protein 70 Click for more detail	Human (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Monocytes	LRR	O60603.fasta	O60603	784	It has the role in immuno inflammation.	Immunoassays	11839622	2002	Pubchem Assay
PRRID_0123	Heat-shock protein 70 Click for more detail	Human (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Monocytes	LRR	O60603.fasta	O60603	784	It has the role in immuno inflammation.	Immunoassays	11839622	2002	Pubchem Assay
PRRID_0124	Heat-shock protein 70 Click for more detail	Human (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	LRR	O00206.fasta	O00206	839	It has the role in immuno inflammation.	Immunoassays	11839622	2002	Pubchem Assay
PRRID_0124	Heat-shock protein 70 Click for more detail	Human (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	LRR	O00206.fasta	O00206	839	It has the role in immuno inflammation.	Immunoassays	11839622	2002	Pubchem Assay
PRRID_0125	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	NA	NA	11842086	2002	Pubchem Assay
PRRID_0125	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Macrophages	NA	O00206.fasta	O00206	839	NA	NA	11842086	2002	Pubchem Assay
PRRID_0126	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	NA	NA	11842086	2002	Pubchem Assay
PRRID_0126	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD	641	Protein	Natural	activation of the NF-Œ∫B pro-inflammatory cascade	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Macrophages	NA	O60603.fasta	O60603	784	NA	NA	11842086	2002	Pubchem Assay
PRRID_0128	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Microvascular endothelial cells	LRR	O00206.fasta	O00206	839	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0128	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Microvascular endothelial cells	LRR	O00206.fasta	O00206	839	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0129	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	5MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	LRR	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0129	Heat-shock proteins 60 Click for more detail	Chlamydia pneumoniae(Bacteria)	5MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY	544	Protein	Natural	Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macrophages	LRR	Q9QUK6.fasta	Q9QUK6	835	This leads to the inflammatory response.	NF-	11801686	2002	Pubchem Assay
PRRID_0130	Hemagglutinin Click for more detail	virus (measles virus)	MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR	617	Glycoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	NA	ELISA	12163593	2002	Pubchem Assay
PRRID_0130	Hemagglutinin Click for more detail	virus (measles virus)	MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR	617	Glycoprotein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9QUN7.fasta	Q9QUN7	784	NA	ELISA	12163593	2002	Pubchem Assay
PRRID_0131	Hyaluronic acid Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Carbohydrate	Natural	potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Bone Marrow‚Äìderived DCs	transmembrane domain that associates with the intra- cellular adaptor protein MyD88	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	11781369	2002	Pubchem Assay
PRRID_0131	Hyaluronic acid Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Carbohydrate	Natural	potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Bone Marrow‚Äìderived DCs	transmembrane domain that associates with the intra- cellular adaptor protein MyD88	Q9QUK6.fasta	Q9QUK6	835	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	11781369	2002	Pubchem Assay
PRRID_0134	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0134	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0135	Mannan Click for more detail	Candida albicans(fungi)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This is responsible for the anti-fungal response of the host immune system.	ELISA	12222939	2002	Pubchem Assay
PRRID_0135	Mannan Click for more detail	Candida albicans(fungi)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This is responsible for the anti-fungal response of the host immune system.	ELISA	12222939	2002	Pubchem Assay
PRRID_0136	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0136	Mannan Click for more detail	S. cerevisiae (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This leads to the inflammatory response.	ELISA	12222939	2002	Pubchem Assay
PRRID_0137	Mannan Click for more detail	Candida albicans(fungi)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This is responsible for the anti-fungal response of the host immune system.	ELISA	12222939	2002	Pubchem Assay
PRRID_0137	Mannan Click for more detail	Candida albicans(fungi)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Monocytes	NA	O00206.fasta	O00206	839	This is responsible for the anti-fungal response of the host immune system.	ELISA	12222939	2002	Pubchem Assay
PRRID_0139	MPL A (monophosphoryl lipid A) Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12377566	2002	NA
PRRID_0139	MPL A (monophosphoryl lipid A) Click for more detail	lipid A derivative (others)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipid	Natural	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12377566	2002	NA
PRRID_0142	Neisserial porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	It leads to the induction of NF-kappaB nuclear translocation.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	It has the role in immunopotentiating activity, such as by stimulate B cells and up-regulate the surface expression of B7-2.	NF-kB luciferase reporter assay	11823477	2002	Pubchem Assay
PRRID_0142	Neisserial porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	It leads to the induction of NF-kappaB nuclear translocation.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Dendritic cells	LRR	Q9QUN7.fasta	Q9QUN7	784	It has the role in immunopotentiating activity, such as by stimulate B cells and up-regulate the surface expression of B7-2.	NF-kB luciferase reporter assay	11823477	2002	Pubchem Assay
PRRID_0143	OspA Click for more detail	Borrelia burgdorferi(Bacteria)	MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK	NA	Lipoprotein	Natural	immunostimulantt	Toll-like receptor 2 (TLR2)+unknown	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	human hyporesponsiveness to OspA vaccination	NA	12091878	2002	NA
PRRID_0143	OspA Click for more detail	Borrelia burgdorferi(Bacteria)	MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK	NA	Lipoprotein	Natural	immunostimulantt	Toll-like receptor 2 (TLR2)+unknown	Toll-like receptor (TLR)	Human	NA	NA	NA	NA	NA	human hyporesponsiveness to OspA vaccination	NA	12091878	2002	NA
PRRID_0145	RC-528 Click for more detail	lipid A derivative (others)	NA	NA	Lipid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12377566	2002	NA
PRRID_0145	RC-528 Click for more detail	lipid A derivative (others)	NA	NA	Lipid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12377566	2002	NA
PRRID_0146	RC529 Click for more detail	lipid A derivative (others)	NA	NA	Lipid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12377566	2002	NA
PRRID_0146	RC529 Click for more detail	lipid A derivative (others)	NA	NA	Lipid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12377566	2002	NA
PRRID_0147	RC544 Click for more detail	lipid A derivative (others)	NA	NA	Lipid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12377566	2002	NA
PRRID_0147	RC544 Click for more detail	lipid A derivative (others)	NA	NA	Lipid	Synthetic	induce systemic production of pro-inflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	NA	NA	12377566	2002	NA
PRRID_0148	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0148	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6, IL-12, type I and II IFNs.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0149	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0149	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of IL-6 and IL-12.	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	Bone-Marrow derived macrophages	LRR	P58681.fasta	P58681	1050	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0150	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay
PRRID_0150	7-allyl-8-oxo-G (loxoribine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Peripheral blood leukocytes	LRR	Q9NYK1.fasta	Q9NYK1	1049	It leads to the immunostimulatory by immune system.	ELISA	12738885	2003	Pubchem Assay

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