Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0007 | ER-112022 Click for more detail | lipid A derivative (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Synthetic | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Chinese Hamster | Chinese hamster ovary fibroblasts | NA | NA | NA | NA | NA | NA | 2473841 | 1989 | NA |
| PRRID_0007 | ER-112022 Click for more detail | lipid A derivative (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Synthetic | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Chinese Hamster | Chinese hamster ovary fibroblasts | NA | NA | NA | NA | NA | NA | 2473841 | 1989 | NA |
| PRRID_0039 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | small chemical derivatives (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | guanosine analogue | Synthetic | Immunostimulant | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 7743561 | 1995 | NA |
| PRRID_0039 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | small chemical derivatives (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | guanosine analogue | Synthetic | Immunostimulant | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 7743561 | 1995 | NA |
| PRRID_0040 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | small chemical derivatives (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | guanosine analogue | Synthetic | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 7743561 | 1995 | NA |
| PRRID_0040 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | small chemical derivatives (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | guanosine analogue | Synthetic | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 7743561 | 1995 | NA |
| PRRID_0053 | MALP-2 (macrophage-activating lipopeptide 2) Click for more detail | Mycoplasma (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | Immunostimulant | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 8549669 | 1996 | NA |
| PRRID_0053 | MALP-2 (macrophage-activating lipopeptide 2) Click for more detail | Mycoplasma (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | Immunostimulant | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 8549669 | 1996 | NA |
| PRRID_0054 | N-Pam-S-Lau2CSK4 Click for more detail | Synthetic (others) | NA | NA | Lipopeptides | Synthetic | Immunostimulant | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 8549669 | 1996 | NA |
| PRRID_0054 | N-Pam-S-Lau2CSK4 Click for more detail | Synthetic (others) | NA | NA | Lipopeptides | Synthetic | Immunostimulant | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | ELISA | 8549669 | 1996 | NA |
| PRRID_0074 | Peptidoglycan (PGN) Click for more detail | S. aureus (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Peptidoglycan recognition by TLR 2 leads to the activation of NF-KB, which leads to the secretion of proinflammatory cytokines. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Fibroblasts | LRR | O60603.fasta | O60603 | 784 | TLR2 is responsible for recognzing the cell wall components of the gram-positive bacteria and induces the respective immune response. | EMSA | 10384090 | 1999 | Pubchem Assay |
| PRRID_0074 | Peptidoglycan (PGN) Click for more detail | S. aureus (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Peptidoglycan recognition by TLR 2 leads to the activation of NF-KB, which leads to the secretion of proinflammatory cytokines. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Fibroblasts | LRR | O60603.fasta | O60603 | 784 | TLR2 is responsible for recognzing the cell wall components of the gram-positive bacteria and induces the respective immune response. | EMSA | 10384090 | 1999 | Pubchem Assay |
| PRRID_0075 | pneumolysin Click for more detail | S. pneumoniae (Bacteria) | MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND | 471 | NA | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | ytokine induction is mediated through NF-kappaB activation | NA | 10411278 | 1999 | Pubchem Assay |
| PRRID_0075 | pneumolysin Click for more detail | S. pneumoniae (Bacteria) | MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND | 471 | NA | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | ytokine induction is mediated through NF-kappaB activation | NA | 10411278 | 1999 | Pubchem Assay |
| PRRID_0081 | CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | induce type I interferons (IFN) and other cytokines production. | NA | 11130078 | 2000 | Pubchem Assay |
| PRRID_0081 | CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | NA | Q9NR96.fasta | Q9NR96 | 1032 | induce type I interferons (IFN) and other cytokines production. | NA | 11130078 | 2000 | Pubchem Assay |
| PRRID_0082 | ER-112022 Click for more detail | lipid A derivative (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Synthetic | It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Raw 264.7 cells | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in immuno inflammation. | ELISA | 11032843 | 2000 | Pubchem Assay |
| PRRID_0082 | ER-112022 Click for more detail | lipid A derivative (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Synthetic | It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Raw 264.7 cells | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in immuno inflammation. | ELISA | 11032843 | 2000 | Pubchem Assay |
| PRRID_0083 | ER-112022 Click for more detail | lipid A derivative (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Synthetic | It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | U373 human astrocytoma cells | LRR | O00206.fasta | O00206 | 839 | It has the role in immuno inflammation. | ELISA | 11032843 | 2000 | Pubchem Assay |
| PRRID_0083 | ER-112022 Click for more detail | lipid A derivative (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Synthetic | It activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | U373 human astrocytoma cells | LRR | O00206.fasta | O00206 | 839 | It has the role in immuno inflammation. | ELISA | 11032843 | 2000 | Pubchem Assay |
| PRRID_0084 | Heat-shock proteins 60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Protein | Natural | immunostimulantt | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | induction of TNF-alpha and NO formation | NA | 10623794 | 2000 | Pubchem Assay |
| PRRID_0084 | Heat-shock proteins 60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Protein | Natural | immunostimulantt | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | NA | O00206.fasta | O00206 | 839 | induction of TNF-alpha and NO formation | NA | 10623794 | 2000 | Pubchem Assay |
| PRRID_0086 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 10679411 | 2000 | NA |
| PRRID_0086 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 10679411 | 2000 | NA |
| PRRID_0087 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Macrophages | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | production of pro-inflammatory cytokines | ELISA | 11095740 | 2000 | Pubchem Assay |
| PRRID_0087 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Macrophages | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | production of pro-inflammatory cytokines | ELISA | 11095740 | 2000 | Pubchem Assay |
| PRRID_0088 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | production of pro-inflammatory cytokines | ELISA | 11095740 | 2000 | Pubchem Assay |
| PRRID_0088 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | production of pro-inflammatory cytokines | ELISA | 11095740 | 2000 | Pubchem Assay |
| PRRID_0090 | Not Determined Click for more detail | herpes simplex virus (virus) | NA | NA | Others | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUN7.fasta | Q9QUN7 | 784 | NA | NA | 11062499 | 2000 | Pubchem Assay |
| PRRID_0090 | Not Determined Click for more detail | herpes simplex virus (virus) | NA | NA | Others | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUN7.fasta | Q9QUN7 | 784 | NA | NA | 11062499 | 2000 | Pubchem Assay |
| PRRID_0097 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | Immunostimulant | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 11431423 | 2001 | NA |
| PRRID_0097 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | Immunostimulant | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 11431423 | 2001 | NA |
| PRRID_0098 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | Immunostimulant | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 11431423 | 2001 | NA |
| PRRID_0098 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | Immunostimulant | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 11431423 | 2001 | NA |
| PRRID_0099 | dsRNA Click for more detail | Type I Lang mammalian reovirus (virus) | NA | NA | Nucleic Acid | Natural | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | (HEK293 t cells) | NA | O15455.fasta | O15455 | 904 | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. | EMSA | 11607032 | 2001 | Pubchem Assay |
| PRRID_0099 | dsRNA Click for more detail | Type I Lang mammalian reovirus (virus) | NA | NA | Nucleic Acid | Natural | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | (HEK293 t cells) | NA | O15455.fasta | O15455 | 904 | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. | EMSA | 11607032 | 2001 | Pubchem Assay |
| PRRID_0100 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Immunostimulant | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | NA | NA | Q9JLF7.fasta | Q9JLF7 | 859 | NA | tandem mass spectrometry | 0 | 2001 | Pubchem Assay |
| PRRID_0100 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Immunostimulant | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | NA | NA | Q9JLF7.fasta | Q9JLF7 | 859 | NA | tandem mass spectrometry | 0 | 2001 | Pubchem Assay |
| PRRID_0101 | Heat-shock proteins 60 Click for more detail | Human (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Protein | Natural | HSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK). | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Fibroblasts | LRR | O60603.fasta | O60603 | 784 | It has the role in immuno inflammation. | Luciferase reporter assay | 11402040 | 2001 | Pubchem Assay |
| PRRID_0101 | Heat-shock proteins 60 Click for more detail | Human (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Protein | Natural | HSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK). | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Fibroblasts | LRR | O60603.fasta | O60603 | 784 | It has the role in immuno inflammation. | Luciferase reporter assay | 11402040 | 2001 | Pubchem Assay |
| PRRID_0102 | Heat-shock proteins 60 Click for more detail | Human (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Protein | Natural | HSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK). | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Fibroblasts | LRR | O00206.fasta | O00206 | 839 | It has the role in immuno inflammation. | Luciferase reporter assay | 11402040 | 2001 | Pubchem Assay |
| PRRID_0102 | Heat-shock proteins 60 Click for more detail | Human (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Protein | Natural | HSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK). | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Fibroblasts | LRR | O00206.fasta | O00206 | 839 | It has the role in immuno inflammation. | Luciferase reporter assay | 11402040 | 2001 | Pubchem Assay |
| PRRID_0105 | MALP-2 (macrophage-activating lipopeptide 2) Click for more detail | Mycoplasma (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | Immunostimulant | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 11431423 | 2001 | NA |
| PRRID_0105 | MALP-2 (macrophage-activating lipopeptide 2) Click for more detail | Mycoplasma (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | Immunostimulant | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 11431423 | 2001 | NA |
| PRRID_0111 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | (HEK293 t cells) | NA | O15455.fasta | O15455 | 904 | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. | EMSA | 11607032 | 2001 | Pubchem Assay |
| PRRID_0111 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | (HEK293 t cells) | NA | O15455.fasta | O15455 | 904 | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. | EMSA | 11607032 | 2001 | Pubchem Assay |
| PRRID_0115 | beta-defensin Click for more detail | Endogenous (others) | MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS | 69 | Peptide | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12411706 | 2002 | NA |
| PRRID_0115 | beta-defensin Click for more detail | Endogenous (others) | MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS | 69 | Peptide | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12411706 | 2002 | NA |
| PRRID_0116 | Fragments of heparan sulphate Click for more detail | Host (Endogenous) (others) | COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O | NA | Proteoglycan | Natural | Heparan sulfate induces nuclear translocation of NF-kappaB. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Bone-Marrow culture | NA | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 plays the role in the activation and maturation of dendritic cells, thus suggesting that vertebrate TLR monitor perturbations to the well-being of tissues. | EMSA | 11994480 | 2002 | Pubchem Assay |
| PRRID_0116 | Fragments of heparan sulphate Click for more detail | Host (Endogenous) (others) | COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O | NA | Proteoglycan | Natural | Heparan sulfate induces nuclear translocation of NF-kappaB. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Bone-Marrow culture | NA | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 plays the role in the activation and maturation of dendritic cells, thus suggesting that vertebrate TLR monitor perturbations to the well-being of tissues. | EMSA | 11994480 | 2002 | Pubchem Assay |
| PRRID_0119 | GP96 Click for more detail | Human (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | It results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces I | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Embryonic Kidney Fibroblasts— 293T | LRR | O60603.fasta | O60603 | 784 | Gp96 has the ability to induce specific immune responses against tumors and pathogens | Luciferase reporter assay | 11912201 | 2002 | Pubchem Assay |
| PRRID_0119 | GP96 Click for more detail | Human (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | It results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces I | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Embryonic Kidney Fibroblasts— 293T | LRR | O60603.fasta | O60603 | 784 | Gp96 has the ability to induce specific immune responses against tumors and pathogens | Luciferase reporter assay | 11912201 | 2002 | Pubchem Assay |
| PRRID_0120 | GP96 Click for more detail | Human (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | It results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces I | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Embryonic Kidney Fibroblasts— 293T | LRR | O00206.fasta | O00206 | 839 | Gp96 has the ability to induce specific immune responses against tumors and pathogens | Luciferase reporter assay | 11912201 | 2002 | Pubchem Assay |
| PRRID_0120 | GP96 Click for more detail | Human (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | It results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces I | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Embryonic Kidney Fibroblasts— 293T | LRR | O00206.fasta | O00206 | 839 | Gp96 has the ability to induce specific immune responses against tumors and pathogens | Luciferase reporter assay | 11912201 | 2002 | Pubchem Assay |
| PRRID_0121 | Gp96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0121 | Gp96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0122 | Gp96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0122 | Gp96 Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0123 | Heat-shock protein 70 Click for more detail | Human (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Monocytes | LRR | O60603.fasta | O60603 | 784 | It has the role in immuno inflammation. | Immunoassays | 11839622 | 2002 | Pubchem Assay |
| PRRID_0123 | Heat-shock protein 70 Click for more detail | Human (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Monocytes | LRR | O60603.fasta | O60603 | 784 | It has the role in immuno inflammation. | Immunoassays | 11839622 | 2002 | Pubchem Assay |
| PRRID_0124 | Heat-shock protein 70 Click for more detail | Human (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | LRR | O00206.fasta | O00206 | 839 | It has the role in immuno inflammation. | Immunoassays | 11839622 | 2002 | Pubchem Assay |
| PRRID_0124 | Heat-shock protein 70 Click for more detail | Human (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | It leads to the secretion of Interleukin-6, tumor necrosis factor (TNF)-alpha, and IL-1beta | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | LRR | O00206.fasta | O00206 | 839 | It has the role in immuno inflammation. | Immunoassays | 11839622 | 2002 | Pubchem Assay |
| PRRID_0125 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0125 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0126 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0126 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | NA | O60603.fasta | O60603 | 784 | NA | NA | 11842086 | 2002 | Pubchem Assay |
| PRRID_0128 | Heat-shock proteins 60 Click for more detail | Chlamydia pneumoniae(Bacteria) | MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY | 544 | Protein | Natural | Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Microvascular endothelial cells | LRR | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | NF- | 11801686 | 2002 | Pubchem Assay |
| PRRID_0128 | Heat-shock proteins 60 Click for more detail | Chlamydia pneumoniae(Bacteria) | MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY | 544 | Protein | Natural | Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Microvascular endothelial cells | LRR | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | NF- | 11801686 | 2002 | Pubchem Assay |
| PRRID_0129 | Heat-shock proteins 60 Click for more detail | Chlamydia pneumoniae(Bacteria) | 5MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY | 544 | Protein | Natural | Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | This leads to the inflammatory response. | NF- | 11801686 | 2002 | Pubchem Assay |
| PRRID_0129 | Heat-shock proteins 60 Click for more detail | Chlamydia pneumoniae(Bacteria) | 5MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVAESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYDALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY | 544 | Protein | Natural | Chlamydial Heat Shock Protein 60 Activates NF-kappaB through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | This leads to the inflammatory response. | NF- | 11801686 | 2002 | Pubchem Assay |
| PRRID_0130 | Hemagglutinin Click for more detail | virus (measles virus) | MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR | 617 | Glycoprotein | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUN7.fasta | Q9QUN7 | 784 | NA | ELISA | 12163593 | 2002 | Pubchem Assay |
| PRRID_0130 | Hemagglutinin Click for more detail | virus (measles virus) | MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR | 617 | Glycoprotein | Natural | Immunostimulant | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | NA | NA | Q9QUN7.fasta | Q9QUN7 | 784 | NA | ELISA | 12163593 | 2002 | Pubchem Assay |
| PRRID_0131 | Hyaluronic acid Click for more detail | Host (Endogenous) (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Carbohydrate | Natural | potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Bone Marrow–derived DCs | transmembrane domain that associates with the intra- cellular adaptor protein MyD88 | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 11781369 | 2002 | Pubchem Assay |
| PRRID_0131 | Hyaluronic acid Click for more detail | Host (Endogenous) (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Carbohydrate | Natural | potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Bone Marrow–derived DCs | transmembrane domain that associates with the intra- cellular adaptor protein MyD88 | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 11781369 | 2002 | Pubchem Assay |
| PRRID_0134 | Mannan Click for more detail | S. cerevisiae (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0134 | Mannan Click for more detail | S. cerevisiae (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0135 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This is responsible for the anti-fungal response of the host immune system. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0135 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This is responsible for the anti-fungal response of the host immune system. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0136 | Mannan Click for more detail | S. cerevisiae (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0136 | Mannan Click for more detail | S. cerevisiae (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This leads to the inflammatory response. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0137 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This is responsible for the anti-fungal response of the host immune system. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0137 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Stimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes | NA | O00206.fasta | O00206 | 839 | This is responsible for the anti-fungal response of the host immune system. | ELISA | 12222939 | 2002 | Pubchem Assay |
| PRRID_0139 | MPL A (monophosphoryl lipid A) Click for more detail | lipid A derivative (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Natural | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12377566 | 2002 | NA |
| PRRID_0139 | MPL A (monophosphoryl lipid A) Click for more detail | lipid A derivative (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipid | Natural | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12377566 | 2002 | NA |
| PRRID_0142 | Neisserial porins Click for more detail | Neisseria meningitidis (Bacteria) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Protein | Natural | It leads to the induction of NF-kappaB nuclear translocation. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Dendritic cells | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in immunopotentiating activity, such as by stimulate B cells and up-regulate the surface expression of B7-2. | NF-kB luciferase reporter assay | 11823477 | 2002 | Pubchem Assay |
| PRRID_0142 | Neisserial porins Click for more detail | Neisseria meningitidis (Bacteria) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Protein | Natural | It leads to the induction of NF-kappaB nuclear translocation. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Dendritic cells | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in immunopotentiating activity, such as by stimulate B cells and up-regulate the surface expression of B7-2. | NF-kB luciferase reporter assay | 11823477 | 2002 | Pubchem Assay |
| PRRID_0143 | OspA Click for more detail | Borrelia burgdorferi(Bacteria) | MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK | NA | Lipoprotein | Natural | immunostimulantt | Toll-like receptor 2 (TLR2)+unknown | Toll-like receptor (TLR) | Human | NA | NA | NA | NA | NA | human hyporesponsiveness to OspA vaccination | NA | 12091878 | 2002 | NA |
| PRRID_0143 | OspA Click for more detail | Borrelia burgdorferi(Bacteria) | MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGGMTVLVSKEKDKDGKYSLDATVDKLELKGTSDKNNGSGTLEGEKTDKSKVKLTIADDLSQTKFEIFKEDGKTLVSKKVTLKDKSSTEEKFNEKGETSEKTIVRANGTRLEYTDIKSDGSGKAKEVLKDFTLEGTLAADGKTTLKVTEGTVVLSKNILKSGEITVALDDSDTTQATKKTGNWDSKSSTLTISVNSQKTKNLVFTKEDTITVQKYDSAGTNLEGKAVEITTLKELKAALK | NA | Lipoprotein | Natural | immunostimulantt | Toll-like receptor 2 (TLR2)+unknown | Toll-like receptor (TLR) | Human | NA | NA | NA | NA | NA | human hyporesponsiveness to OspA vaccination | NA | 12091878 | 2002 | NA |
| PRRID_0145 | RC-528 Click for more detail | lipid A derivative (others) | NA | NA | Lipid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12377566 | 2002 | NA |
| PRRID_0145 | RC-528 Click for more detail | lipid A derivative (others) | NA | NA | Lipid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12377566 | 2002 | NA |
| PRRID_0146 | RC529 Click for more detail | lipid A derivative (others) | NA | NA | Lipid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12377566 | 2002 | NA |
| PRRID_0146 | RC529 Click for more detail | lipid A derivative (others) | NA | NA | Lipid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12377566 | 2002 | NA |
| PRRID_0147 | RC544 Click for more detail | lipid A derivative (others) | NA | NA | Lipid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12377566 | 2002 | NA |
| PRRID_0147 | RC544 Click for more detail | lipid A derivative (others) | NA | NA | Lipid | Synthetic | induce systemic production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 12377566 | 2002 | NA |
| PRRID_0148 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0148 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0149 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0149 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0150 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0150 | 7-allyl-8-oxo-G (loxoribine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |