Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0151 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0151 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0152 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0152 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0153 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0153 | 7-deazadG Click for more detail | Guanosine (others) | C1C(C(OC1N2C=CC3=C2NC(=NC3=O)N)CO)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0154 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0154 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0155 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0155 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0156 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0156 | 7-deazaguanosine (7-deazaG) Click for more detail | Guanosine (others) | C1=CN(C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0157 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0157 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0158 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0158 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0159 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0159 | 7-Thia-8-oxoguanosine (TOG) Click for more detail | Guanosine (others) | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0160 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0160 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of IL-6, IL-12, type I and II IFNs. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0161 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0161 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of IL-6 and IL-12. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Bone-Marrow derived macrophages | LRR | P58681.fasta | P58681 | 1050 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0162 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0162 | 9-hexyl-guanine Click for more detail | Guanosine (others) | CCN1C=NC2=C1NC(=NC2=O)N | NA | Nucleic Acid | Synthetic | It induces the production of type I IFNs, tumor necrosis factor alpha and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Peripheral blood leukocytes | LRR | Q9NYK1.fasta | Q9NYK1 | 1049 | It leads to the immunostimulatory by immune system. | ELISA | 12738885 | 2003 | Pubchem Assay |
| PRRID_0177 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | NA | P58681.fasta | P58681 | 1050 | It leads to the endosomal maturation. | ELISA | 14579267 | 2003 | Pubchem Assay |
| PRRID_0177 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | Loxoribine (7-allyl-7,8- dihydro-8-oxo-guanosine) activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | Spleenocytes | NA | P58681.fasta | P58681 | 1050 | It leads to the endosomal maturation. | ELISA | 14579267 | 2003 | Pubchem Assay |
| PRRID_0182 | PIM2 Click for more detail | Mtb H37Rv (Bacteria) | NA | NA | Carbohydrate | Natural | It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Primary Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response. | ELISA | 12775723 | 2003 | Pubchem Assay |
| PRRID_0182 | PIM2 Click for more detail | Mtb H37Rv (Bacteria) | NA | NA | Carbohydrate | Natural | It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Primary Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response. | ELISA | 12775723 | 2003 | Pubchem Assay |
| PRRID_0183 | PIM2 Click for more detail | Mtb H37Rv (Bacteria) | NA | NA | Carbohydrate | Natural | It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Primary Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response. | ELISA | 12775723 | 2003 | Pubchem Assay |
| PRRID_0183 | PIM2 Click for more detail | Mtb H37Rv (Bacteria) | NA | NA | Carbohydrate | Natural | It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Primary Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response. | ELISA | 12775723 | 2003 | Pubchem Assay |
| PRRID_0184 | PIM6 Click for more detail | Mycobacterium bovis Bacillus Calmette Guerin (Bacteria) | NA | NA | Carbohydrate | Natural | It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Primary Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response. | ELISA | 12775723 | 2003 | Pubchem Assay |
| PRRID_0184 | PIM6 Click for more detail | Mycobacterium bovis Bacillus Calmette Guerin (Bacteria) | NA | NA | Carbohydrate | Natural | It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Primary Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response. | ELISA | 12775723 | 2003 | Pubchem Assay |
| PRRID_0185 | PIM6 Click for more detail | Mtb H37Rv (Bacteria) | NA | NA | Carbohydrate | Natural | It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Primary Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response. | ELISA | 12775723 | 2003 | Pubchem Assay |
| PRRID_0185 | PIM6 Click for more detail | Mtb H37Rv (Bacteria) | NA | NA | Carbohydrate | Natural | It stimulates the stimulate TNF-alpha, which leads to IL-12 p40 secretion. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Primary Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response. | ELISA | 12775723 | 2003 | Pubchem Assay |
| PRRID_0186 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | Spleenocytes | NA | P58682.fasta | P58682 | 1032 | It leads to the endosomal maturation. | ELISA | 14579267 | 2003 | Pubchem Assay |
| PRRID_0186 | Resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Resisuimod activates the MyD88-dependent TLR/IL-1R signaling pathway and induces the cytokine production. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | Spleenocytes | NA | P58682.fasta | P58682 | 1032 | It leads to the endosomal maturation. | ELISA | 14579267 | 2003 | Pubchem Assay |
| PRRID_0195 | Double-stranded ribonucleic acid (dsRNA) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | O15455.fasta | O15455 | 904 | production of pro-inflammatory cytokines | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0195 | Double-stranded ribonucleic acid (dsRNA) Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | O15455.fasta | O15455 | 904 | production of pro-inflammatory cytokines | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0196 | dsRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0196 | dsRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0197 | Envelope protein Click for more detail | virus (Mouse Mammary Tumor Virus) | NA | NA | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 14694089 | 2004 | Pubchem Assay |
| PRRID_0197 | Envelope protein Click for more detail | virus (Mouse Mammary Tumor Virus) | NA | NA | Protein | Natural | activation of the NF-κB pro-inflammatory cascade | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | NA | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 14694089 | 2004 | Pubchem Assay |
| PRRID_0198 | glucuronoxylomannan Click for more detail | Cryptococcus neoformans(fungi) | NA | NA | Carbohydrate | Natural | It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Lung | NA | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to the inflammatory response against the fungi Cryptococcus neoformans. | ELISA | 15322035 | 2004 | Pubchem Assay |
| PRRID_0198 | glucuronoxylomannan Click for more detail | Cryptococcus neoformans(fungi) | NA | NA | Carbohydrate | Natural | It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Lung | NA | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to the inflammatory response against the fungi Cryptococcus neoformans. | ELISA | 15322035 | 2004 | Pubchem Assay |
| PRRID_0199 | glucuronoxylomannan Click for more detail | Cryptococcus neoformans(fungi) | NA | NA | Carbohydrate | Natural | It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response against the fungi Cryptococcus neoformans. | ELISA | 15322035 | 2004 | Pubchem Assay |
| PRRID_0199 | glucuronoxylomannan Click for more detail | Cryptococcus neoformans(fungi) | NA | NA | Carbohydrate | Natural | It leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung | NA | Q9QUN7.fasta | Q9QUN7 | 784 | It leads to the inflammatory response against the fungi Cryptococcus neoformans. | ELISA | 15322035 | 2004 | Pubchem Assay |
| PRRID_0200 | glycoinositolphospholipids Click for more detail | Trypanosoma (others) | NA | NA | Glycolipid | Natural | It induces the secretion of TNF-alpha and IL-12, which leads the production of cytokine IFN-gamma | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | It leads to the production of the IFN-gamma, which is a key cytokine in host resistance to infection with T. cruzi. | NA | 15361229 | 2004 | NA |
| PRRID_0200 | glycoinositolphospholipids Click for more detail | Trypanosoma (others) | NA | NA | Glycolipid | Natural | It induces the secretion of TNF-alpha and IL-12, which leads the production of cytokine IFN-gamma | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | It leads to the production of the IFN-gamma, which is a key cytokine in host resistance to infection with T. cruzi. | NA | 15361229 | 2004 | NA |
| PRRID_0204 | Heme Click for more detail | Endogenous (others) | CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O | NA | Others | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 17502383 | 2004 | NA |
| PRRID_0204 | Heme Click for more detail | Endogenous (others) | CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O | NA | Others | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 17502383 | 2004 | NA |
| PRRID_0205 | Influenza virus Click for more detail | Influenza A (virus) | NA | NA | Whole cell | Natural | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0205 | Influenza virus Click for more detail | Influenza A (virus) | NA | NA | Whole cell | Natural | It leads to the activation of NF-kappaB via TRIF adaptor molecule, which results into the secretion of the cytokines IL-8, IL-6, RANTES (regulated on activation normal T cell expressed and secreted), and interferon- and the up-regulation of the major adhesion molecule ICAM-1. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Alveolar and bronchial epithelial cells | NA | O15455.fasta | O15455 | 904 | It causes pulmonary inflammation. | ELISA | 15579900 | 2004 | Pubchem Assay |
| PRRID_0206 | Not Determined Click for more detail | Uropathogenic E.coli (Bacteria) | NA | NA | Others | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | macrophages and liver, kidney, and bladder epithelial cells | NA | NA | NA | NA | NA | NA | 15001781 | 2004 | NA |
| PRRID_0206 | Not Determined Click for more detail | Uropathogenic E.coli (Bacteria) | NA | NA | Others | Natural | elicit innate immune response | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | macrophages and liver, kidney, and bladder epithelial cells | NA | NA | NA | NA | NA | NA | 15001781 | 2004 | NA |
| PRRID_0211 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0211 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0212 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NR97.fasta | Q9NR97 | 1041 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0212 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | leads to stimulation of innate immune cells | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | peripheral blood mononuclear cells (PBMCs) | NA | Q9NR97.fasta | Q9NR97 | 1041 | important role in the immune response to viral infection | ELISA | 14976262 | 2004 | Pubchem Assay |
| PRRID_0213 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 14976261 | 2004 | NA |
| PRRID_0213 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 14976261 | 2004 | NA |
| PRRID_0214 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 14976261 | 2004 | NA |
| PRRID_0214 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | induce type I interferons (IFN) and other cytokines production. | NA | 14976261 | 2004 | NA |
| PRRID_0217 | tGPI-mucin Click for more detail | Trypanosoma (others) | MKWSALNMNEGRGQLNCFCDGYWLHFPWTNNPRDVRGSSFFCYFAFVLLCALHLLLCVCVPSVRGADTTDRSRRMCMRWSLVCRSCLHLPLPSMCWCCGRAVCVCVCVCLLPWIGVCVVRGVRRTVHAWLLPSPHVVCPLCVCLPHLSSPLLLSISLTVQISSTPLNDHTMMTTCRLLCALLVLALCCCPFLCVTATGTAKELNKADASAPSPPSNPPATTTGESGLQDVVSAAEPQDVDGDVRGTSGSETQSDGAADKSQKHDNNDTTGSQGSTNRSADQTDQNGEDPAATTTTTTTAPVAPSTTTTTEAPTTTTTRAPSRLREIDGSLSSSAWVCAPLLLAASALAYTTVG | 353 | Glycoprotein | Natural | It induces the secretion of TNF-alpha and IL-12, which leads the production of cytokine IFN-gamma | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | It leads to the production of the IFN-gamma, which is a key cytokine in host resistance to infection with T. cruzi. | NA | 15361229 | 2004 | NA |
| PRRID_0217 | tGPI-mucin Click for more detail | Trypanosoma (others) | MKWSALNMNEGRGQLNCFCDGYWLHFPWTNNPRDVRGSSFFCYFAFVLLCALHLLLCVCVPSVRGADTTDRSRRMCMRWSLVCRSCLHLPLPSMCWCCGRAVCVCVCVCLLPWIGVCVVRGVRRTVHAWLLPSPHVVCPLCVCLPHLSSPLLLSISLTVQISSTPLNDHTMMTTCRLLCALLVLALCCCPFLCVTATGTAKELNKADASAPSPPSNPPATTTGESGLQDVVSAAEPQDVDGDVRGTSGSETQSDGAADKSQKHDNNDTTGSQGSTNRSADQTDQNGEDPAATTTTTTTAPVAPSTTTTTEAPTTTTTRAPSRLREIDGSLSSSAWVCAPLLLAASALAYTTVG | 353 | Glycoprotein | Natural | It induces the secretion of TNF-alpha and IL-12, which leads the production of cytokine IFN-gamma | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | It leads to the production of the IFN-gamma, which is a key cytokine in host resistance to infection with T. cruzi. | NA | 15361229 | 2004 | NA |
| PRRID_0218 | Biglycan Click for more detail | Endogenous (others) | MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT | 238 | Carbohydrate | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | synthesis of TNF-alpha and MIP-2. | Western blotting and ELISA. | 16025156 | 2005 | Pubchem Assay |
| PRRID_0218 | Biglycan Click for more detail | Endogenous (others) | MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT | 238 | Carbohydrate | Natural | Immunostimulant | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | NA | O00206.fasta | O00206 | 839 | synthesis of TNF-alpha and MIP-2. | Western blotting and ELISA. | 16025156 | 2005 | Pubchem Assay |
| PRRID_0219 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocytic cell line | extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 15661917 | 2005 | NA |
| PRRID_0219 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Lipopeptides | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocytic cell line | extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 15661917 | 2005 | NA |
| PRRID_0222 | Hemozoin Click for more detail | protozoa (Plasmodium falciparum) (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | Others | Natural | immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Toll/interleukin 1 receptor domain | Q9NR96.fasta | Q9NR96 | 1032 | abrogated HZ-induced cytokine production | NA | 15630134 | 2005 | Pubchem Assay |
| PRRID_0222 | Hemozoin Click for more detail | protozoa (Plasmodium falciparum) (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | Others | Natural | immunostimulant | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Toll/interleukin 1 receptor domain | Q9NR96.fasta | Q9NR96 | 1032 | abrogated HZ-induced cytokine production | NA | 15630134 | 2005 | Pubchem Assay |
| PRRID_0223 | Microparticles containingOVAand poly-U Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | BMDCs | NA | P58681.fasta | P58681 | 1050 | It stimulates proinflammatory and antiviral responses. | ELISA | 16278038 | 2005 | Pubchem Assay |
| PRRID_0223 | Microparticles containingOVAand poly-U Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | BMDCs | NA | P58681.fasta | P58681 | 1050 | It stimulates proinflammatory and antiviral responses. | ELISA | 16278038 | 2005 | Pubchem Assay |
| PRRID_0224 | Microparticles containingOVAand poly-U Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | BMDCs | NA | P58682.fasta | P58682 | 1032 | It stimulates proinflammatory and antiviral responses. | ELISA | 16278038 | 2005 | Pubchem Assay |
| PRRID_0224 | Microparticles containingOVAand poly-U Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | ssRNA can act as a potent adjuvant and modulator of adaptive immunological responses, which leads to the enhanced production of TNF-alpha and IL-12p40. | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | BMDCs | NA | P58682.fasta | P58682 | 1032 | It stimulates proinflammatory and antiviral responses. | ELISA | 16278038 | 2005 | Pubchem Assay |
| PRRID_0226 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocytic cell line | extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 15661917 | 2005 | NA |
| PRRID_0226 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | monocytic cell line | extracellular leucine-rich mo- tifs, and a cytoplasmic domain called the Toll/IL-1R homology domain | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | ELISA | 15661917 | 2005 | NA |
| PRRID_0227 | profilin-like protein Click for more detail | protozoa (Toxoplasma gondi) (others) | MSDWDPVVKEWLVDTGYCCAGGIANAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 163 | Protein | Natural | Immunostimulant | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 15860593 | 2005 | NA |
| PRRID_0227 | profilin-like protein Click for more detail | protozoa (Toxoplasma gondi) (others) | MSDWDPVVKEWLVDTGYCCAGGIANAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 163 | Protein | Natural | Immunostimulant | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | NA | NA | 15860593 | 2005 | NA |
| PRRID_0228 | Seeligeriolysin O ((rLSO483) Click for more detail | Listeria seeligeri (Bacteria) | MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ | 530 | Protein | Natural | It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | This leads to the inflammatory response. | Transfection and nuclear factor j-B reporter assay | 16291660 | 2005 | Pubchem Assay |
| PRRID_0228 | Seeligeriolysin O ((rLSO483) Click for more detail | Listeria seeligeri (Bacteria) | MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ | 530 | Protein | Natural | It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | This leads to the inflammatory response. | Transfection and nuclear factor j-B reporter assay | 16291660 | 2005 | Pubchem Assay |
| PRRID_0229 | Seeligeriolysin O ((rLSO483) Click for more detail | Listeria seeligeri (Bacteria) | MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ | 530 | Protein | Natural | It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | NA | Q9QUK6.fasta | Q9QUK6 | 835 | This leads to the inflammatory response. | Transfection and nuclear factor j-B reporter assay | 16291660 | 2005 | Pubchem Assay |
| PRRID_0229 | Seeligeriolysin O ((rLSO483) Click for more detail | Listeria seeligeri (Bacteria) | MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ | 530 | Protein | Natural | It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | NA | Q9QUK6.fasta | Q9QUK6 | 835 | This leads to the inflammatory response. | Transfection and nuclear factor j-B reporter assay | 16291660 | 2005 | Pubchem Assay |
| PRRID_0230 | Seeligeriolysin O (rLSO530) Click for more detail | Listeria seeligeri (Bacteria) | MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ | 530 | Protein | Natural | It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | This leads to the inflammatory response. | Transfection and nuclear factor j-B reporter assay | 16291660 | 2005 | Pubchem Assay |
| PRRID_0230 | Seeligeriolysin O (rLSO530) Click for more detail | Listeria seeligeri (Bacteria) | MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ | 530 | Protein | Natural | It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Macrophages | NA | Q9QUN7.fasta | Q9QUN7 | 784 | This leads to the inflammatory response. | Transfection and nuclear factor j-B reporter assay | 16291660 | 2005 | Pubchem Assay |
| PRRID_0231 | Seeligeriolysin O (rLSO530) Click for more detail | Listeria seeligeri (Bacteria) | MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ | 530 | Protein | Natural | It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | NA | Q9QUK6.fasta | Q9QUK6 | 835 | This leads to the inflammatory response. | Transfection and nuclear factor j-B reporter assay | 16291660 | 2005 | Pubchem Assay |
| PRRID_0231 | Seeligeriolysin O (rLSO530) Click for more detail | Listeria seeligeri (Bacteria) | MKIFGLVIMSLLFVSLPITQQPEARDVPAYDRSEVTISPAETPESPPATPKTPVEKKHAEEINKYIWGLNYDKNSILVYQGEAVTNVPPKKGYKDGSEYIVVEKKKKGINQNNADISVINAISSLTYPGALVKANRELVENQPNVLPVKRDSLTLSVDLPGMTKKDNKIFVKNPTKSNVNNAVNTLVERWNDKYSKAYPNINAKIDYSDEMAYSESQLIAKFGTAFKAVNNSLNVNFEAISDGKVQEEVISFKQIYYNINVNEPTSPSKFFGGSVTKEQLDALGVNAENPPAYISSVAYGRQVYVKLSSSSHSNKVKTAFEAAMSGKSVKGDVELTNIIKNSSFKAVIYGGSAKEEVEIIDGNLGELRDILKKGSTYDRENPGVPISYTTNFLKDNDLAVVKNNSEYIETTSKSYTDGKINIDHSGGYVAQFNISWDEVSYDENGNEIKVHKKWGENYKSKLAHFTSSIYLPGNARNINIYARECTGLFWEWWRTVIDDRNLPLVKNRNVSIWGTTLYPRHSNNVDNPIQ | 530 | Protein | Natural | It induces TNF-alpha production and NF-kappaB activation, which leads to the production of IL-12 p40 and IL-12 p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | NA | Q9QUK6.fasta | Q9QUK6 | 835 | This leads to the inflammatory response. | Transfection and nuclear factor j-B reporter assay | 16291660 | 2005 | Pubchem Assay |
| PRRID_0232 | crystallin Click for more detail | Host (Endogenous) (others) | MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS | 173 | Protein | Natural | It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Synovial tissue | NA | O00206.fasta | O00206 | 839 | It leads to the activationa and maturation of the dendritic cells | Cyokine assay | 16709864 | 2006 | Pubchem Assay |
| PRRID_0232 | crystallin Click for more detail | Host (Endogenous) (others) | MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS | 173 | Protein | Natural | It leads to the increased production of the inflammatory mediators TNF-alpha, IL-6, IL-10, and IL-12p70. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Synovial tissue | NA | O00206.fasta | O00206 | 839 | It leads to the activationa and maturation of the dendritic cells | Cyokine assay | 16709864 | 2006 | Pubchem Assay |
| PRRID_0233 | 3M-001 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | elicit innate immune response | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | dendritic cells | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | Pubchem Assay |
| PRRID_0233 | 3M-001 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | elicit innate immune response | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | dendritic cells | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | Pubchem Assay |
| PRRID_0234 | 3M-001 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | NA |
| PRRID_0234 | 3M-001 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | NA |
| PRRID_0235 | 3M-002 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | dendritic cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | Pubchem Assay |
| PRRID_0235 | 3M-002 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | elicit innate immune response | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | dendritic cells | NA | Q9NR97.fasta | Q9NR97 | 1041 | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | Pubchem Assay |
| PRRID_0236 | 3M-002 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | NA |
| PRRID_0236 | 3M-002 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | NA |
| PRRID_0237 | 3M-003 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | elicit innate immune response | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | NA |
| PRRID_0237 | 3M-003 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | elicit innate immune response | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | NA |
| PRRID_0238 | 3M-003 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | NA |
| PRRID_0238 | 3M-003 Click for more detail | small chemical derivatives (others) | NA | NA | imidazoquinolines | Synthetic | Immunostimulant | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | NA | NA | NA | NA | NA | NA | production of pro-inflammatory cytokines | NA | 17114492 | 2006 | NA |