PCMdb: Pancreatic Cancer Methylation Database

Circulating Free Nucleic Acid Genes reported in cancers and present in PCMdb

This page gives a list of genes that have been reported to be potential biomarkers in cancers other than pancreatic cancer as free nucleic acid fragments originated from these genes and circulate in blood and the methylation status of these genes can be found out from these circulating free nucleic acid fragments. Corresponding to each gene, the number of entries in PCMdb that report high, intermediate or low level methylation has been given. For more information, please click HERE .

** : Information from other litratures

# : Infromation from our data collection (PCMdb)

S. No.	** Reported Methylated Gene	** Reported Cancer Type	# of PCMdb Entries	# of High Methylation	# of Intermediate Methylation	# of Low Methylation	# of Cell Lines studied
Search:
1	ALX4	Colorectal,Bladder	229	108	0	0	27
2	APBA1	Bladder	12	12	0	0	12
3	APC	Breast,Lung,Hepatocellular,Bladder,Prostate	100	33	0	0	20
4	BCL2	Bladder	40	16	0	0	20
5	BMP6	Breast	9	9	0	0	9
6	BRCA1	Breast,Ovarian,Bladder	12	12	0	0	12
7	CALCA	Ovarian	49	23	0	0	27
8	CCNA1	Head and Neck Squamous Cell,Bladder	82	58	0	0	34
9	CCND2	Pancreatic	141	57	0	0	34
10	CDH13	Non Small Cell Lung,Bladder,Lung	143	75	0	0	28
11	CDH17	Prostate,Bladder,Renal Cell	12	12	0	0	12
12	CDH4	Colorectal	9	9	0	0	9
13	CDKN2A	Non Small Cell Lung,Lung	1	1	0	0	1
14	CYP26B1	Gastric	29	18	0	0	27
15	DAPK	Lung	9	0	0	8	9
16	DAPK1	Lung	32	18	0	0	28
17	DCC	Head and Neck Squamous Cell,Lung	180	74	0	0	20
18	DKK3	Breast	6	0	0	6	6
19	EPB41L3	Lung	20	13	0	0	20
20	ESR1	Breast	102	53	0	0	34
21	GATA4	Non Small Cell Lung,Colorectal	20	8	0	0	20
22	GATA5	Lung	9	9	0	0	9
23	GREM1	Bladder	29	17	0	0	27
24	HIC1	Head and Neck Squamous Cell,Ovarian	24	24	0	0	20
25	HOXA9	Bladder	121	86	0	0	34
26	HSPA2	Bladder	9	9	0	0	9
27	IGFBP3	Non Small Cell Lung	110	52	0	0	27
28	ITGA4	Bladder	30	17	0	0	27
29	KCNA4	Gastric	40	15	0	0	20
30	KCNV1	Bladder	30	14	0	0	27
31	KLK10	Lung	20	6	0	0	20
32	KLK3	Prostate	20	5	0	0	20
33	LCN2	Pancreatic	12	12	0	0	12
34	MGMT	Head and Neck Squamous Cell	30	8	0	9	22
35	MINT1	Bladder	9	0	0	4	9
36	MINT31	Head and Neck Squamous Cell	9	0	0	2	9
37	MLH1	Gastric	60	19	0	0	20
38	MYOD1	Bladder	102	54	0	0	34
39	NDRG4	Colorectal	41	11	0	0	20
40	NEUROD1	Breast	49	25	0	0	27
41	NGFR	Colorectal	9	0	0	9	9
42	NPTX2	Pancreatic	52	33	0	0	29
43	PAX5	Ovarian	36	15	0	0	28
44	PCDH17	Prostate,Bladder,Renal	29	14	0	0	27
45	PGR	Ovarian	10	9	0	0	10
46	PITX2	Breast	61	39	0	0	34
47	PLAU	Pancreatic	9	0	0	9	9
48	POU4F2	Bladder	49	31	0	0	27
49	RARRES1	Bladder	1	0	0	0	1
50	RARB2	Breast,Bladder	9	0	0	4	9
51	RASSF1	Breast	20	5	0	0	20
52	RASSF1A	Breast,Lung,Hepatocellular,Ovarian,Bladder,Prostate	8	5	2	1	8
53	REPRIMO	Prostate	18	9	0	1	9
54	RPRM	Prostate,Bladder	40	15	0	0	20
55	RUNX3	Colorectal,Bladder	108	45	4	3	34
56	SALL3	Bladder	50	33	0	0	27
57	SEPT9	Colorectal	9	9	0	0	9
58	SFRP1	Hepatocellular	103	62	0	1	34
59	SOCS1	Pancreatic,Melanoma	23	14	0	0	21
60	SOCS2	Melanoma	129	63	0	0	27
61	SOX17	Breast	41	31	0	0	34
62	TAL1	Bladder	13	12	0	0	12
63	TCF21	Prostate,Bladder,Renal	29	10	0	9	27
64	TERT	Lung	9	9	0	0	9
65	TFPI2	Hepatocellular,Colorectal	142	62	0	0	34
66	THBS1	Ovarian	9	0	0	8	9
67	TIMP3	Head and Neck Squamous Cell,Bladder,Breast	81	31	0	8	29
68	TITF1	Breast	20	6	0	0	20
69	TMEFF2	Colorectal,Bladder	12	12	0	0	12
70	TMS1	Non Small Cell Lung	3	1	0	2	3
71	UCHL1	Head and Neck Squamous Cell	58	32	0	0	22
72	VAX1	Bladder	9	9	0	0	9
73	VIM	Colorectal,Bladder	29	14	0	0	27
74	WIF1	Colorectal	29	15	0	0	27
75	WT1	Lung	281	144	0	0	34
76	ZNF154	Bladder	50	35	0	0	27
77	hMLH1	Colorectal cancer	9	0	9	0	9

Team

Raghava

CSIR-IMTECH

CSIR