| 1 | Preliminary study analyzing the methylated genes in the plasma of patients with pancreatic cancer. | 22414467 |
| 2 | Reduced levels of p15INK4b, p16INK4a, p21cip1 and p27kip1 in pancreatic carcinoma. | 22293850 |
| 3 | Genome-wide CpG island profiling of intraductal papillary mucinous neoplasms of the pancreas. | 22173550 |
| 4 | Dickkopf3 overexpression inhibits pancreatic cancer cell growth in vitro. | 21987623 |
| 5 | Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma. | 21610144 |
| 6 | Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma. | 21572398 |
| 7 | Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines. | 21269942 |
| 8 | SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma. | 20939879 |
| 9 | DNA methylation and histone H3-K9 modifications contribute to MUC17 expression. | 20926598 |
| 10 | Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. | 20173668 |
| 11 | Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion. | 19893036 |
| 12 | Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. | 19223499 |
| 13 | Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells. | 19035457 |
| 14 | DNA methylation alterations in endoscopic retrograde cholangiopancreatography brush samples of patients with suspected pancreaticobiliary disease. | 18995218 |
| 15 | Multiple genes are hypermethylated in intraductal papillary mucinous neoplasms of the pancreas. | 18820670 |
| 16 | Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma. | 18535405 |
| 17 | Hypermethylation and aberrant expression of secreted frizzled-related protein genes in pancreatic cancer. | 18528941 |
| 18 | Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. | 18492726 |
| 19 | Adverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer. | 18475302 |
| 20 | MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells. | 18413738 |
| 21 | Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. | 18223216 |
| 22 | CpG island methylation profile of pancreatic intraepithelial neoplasia. | 18157091 |
| 23 | Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines. | 17895890 |
| 24 | Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. | 17675336 |
| 25 | DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. | 16537562 |
| 26 | Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. | 16479257 |
| 27 | DNA methylation alterations in the pancreatic juice of patients with suspected pancreatic disease. | 16424060 |
| 28 | Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis. | 16258509 |
| 29 | Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. | 15985168 |
| 30 | Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. | 15970691 |
| 31 | The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer. | 15662133 |
| 32 | Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. | 15383627 |
| 33 | Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. | 15289340 |
| 34 | Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers. | 15121754 |
| 35 | The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. | 15073125 |
| 36 | Ubiquitous aberrant RASSF1A promoter methylation in childhood neoplasia. | 14871978 |
| 37 | CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene. | 14645499 |
| 38 | Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas. | 14614047 |
| 39 | Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. | 14501508 |
| 40 | Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. | 12874021 |
| 41 | Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. | 12865927 |
| 42 | Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. | 12839967 |
| 43 | O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme. | 12684420 |
| 44 | Significance of thymidylate synthase activity in renal cell carcinoma. | 12684419 |
| 45 | Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues. | 12684418 |
| 46 | Diagnosing pancreatic cancer using methylation specific PCR analysis of pancreatic juice. | 12673124 |
| 47 | Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. | 12651607 |
| 48 | Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors. | 12629131 |
| 49 | Methylation status of p14ARF and p16INK4a as detected in pancreatic secretions. | 12610506 |
| 50 | Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness. | 12591989 |
| 51 | Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas. | 12584167 |
| 52 | Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs. | 12432281 |
| 53 | Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma. | 12000709 |
| 54 | Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors. | 11965547 |
| 55 | Aberrant CpG island methylation in cancer cell lines arises in the primary cancers from which they were derived. | 11960385 |
| 56 | Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. | 11786397 |
| 57 | p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb. | 11753042 |
| 58 | Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma. | 11731440 |
| 59 | Tumor suppressor genes in the 9p21 gene cluster are selective targets of inactivation in neuroendocrine gastroenteropancreatic tumors. | 11479232 |
| 60 | The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. | 11420696 |
| 61 | Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability. | 11306499 |
| 62 | Alterations in the p16INK4a/CDKN2A tumor suppressor gene in gastrinomas. | 11095446 |
| 63 | Hypermethylation of multiple genes in pancreatic adenocarcinoma. | 10766168 |
| 64 | Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. | 10644993 |
| 65 | Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. | 10029064 |
| 66 | Genetic alterations in gastrinomas and nonfunctioning pancreatic neuroendocrine tumors: an analysis of p16/MTS1 tumor suppressor gene inactivation. | 9443399 |
| 67 | Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. | 9242437 |
| 68 | zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells. | 10495427 |
| 69 | Low frequency of p16(INK4a) alterations in insulinomas. | 11025365 |
| 70 | p16(INK4a) alterations in chronic pancreatitis-indicator for high-risk lesions for pancreatic cancer. | 11283541 |
| 71 | De novo expression of the Muc2 gene in pancreas carcinoma cells is triggered by promoter demethylation. | 11893907 |
| 72 | Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas. | 12105864 |
| 73 | Tumor-suppressing pathways in cystic pancreatic tumors. | 12499916 |
| 74 | Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. | 12527896 |
| 75 | Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells. | 12527922 |
| 76 | CpG island methylation in carcinoid and pancreatic endocrine tumors. | 12584572 |
| 77 | Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma. | 12802288 |
| 78 | Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma: immunohistochemical and genetic findings compared with clinicopathological parameters. | 12898359 |
| 79 | SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. | 12902985 |
| 80 | Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms. | 14668721 |
| 81 | Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling. | 14716296 |
| 82 | Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines. | 14743205 |
| 83 | Frequent promoter methylation and gene silencing of CDH13 in pancreatic cancer. | 15245595 |
| 84 | Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers. | 15467763 |
| 85 | Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas. | 15714128 |
| 86 | Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. | 15824892 |
| 87 | Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression. | 15870692 |
| 88 | Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. | 15942716 |
| 89 | Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing. | 16112420 |
| 90 | Differential and epigenetic gene expression profiling identifies frequent disruption of the RELN pathway in pancreatic cancers. | 16472607 |
| 91 | E-cadherin and DAP kinase in pancreatic adenocarcinoma and corresponding lymph node metastases. | 16596173 |
| 92 | Aberrant methylation of secreted apoptosis-related protein 2 (SARP2) in pure pancreatic juice in diagnosis of pancreatic neoplasms. | 16670620 |
| 93 | MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. | 16721789 |
| 94 | Preproenkephalin hypermethylation in the pure pancreatic juice compared with p53 mutation in the diagnosis of pancreatic carcinoma. | 16988769 |
| 95 | Evaluation of CDKN2C/p18, CDKN1B/p27 and CDKN2B/p15 mRNA expression, and CpG methylation status in sporadic and MEN1-associated pancreatic endocrine tumours. | 17803708 |
| 96 | Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells. | 18394600 |
| 97 | Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer. | 18437076 |
| 98 | Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma. | 19170121 |
| 99 | Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation. | 19465885 |
| 100 | Characterizing DNA methylation patterns in pancreatic cancer genome. | 19497796 |
| 101 | High-resolution melting analysis of BLU methylation levels in gastric, colorectal, and pancreatic cancers. | 20394502 |
| 102 | Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. | 20428826 |
| 103 | Methylation-mediated silencing of TMS1 in pancreatic cancer and its potential contribution to chemosensitivity. | 21036703 |
| 104 | Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array). | 21723258 |
| 105 | The role of quantitative NPTX2 hypermethylation as a novel serum diagnostic marker in pancreatic cancer. | 21778928 |
| 106 | Aberrant methylation of RASSF2A in human pancreatic ductal adenocarcinoma and its relation to clinicopathologic features. | 21792082 |
| 107 | Hypermethylation of HIC1 Promoter and Aberrant Expression of HIC1/SIRT1 Might Contribute to the Carcinogenesis of Pancreatic Cancer. | 22552606 |
| 108 | Neuronal pentraxin II (NPTX2) is frequently down-regulated by promoter hypermethylation in pancreatic cancers. | 22806544 |
| 109 | Site- and grade-specific diversity of LINE1 methylation pattern in gastroenteropancreatic neuroendocrine tumours. | 22993308 |
| 110 | SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling. | 23318427 |
