Browse result page of AntiTbPdb
The total number entries retrieved from this search are 195
| ID | Name | Sequence | N-Terminal Modification | C-Terminal Modification | Chemical Modification | Linear/Cyclic | Length | Chirality | Nature | Source | Origin | Species | Strain | Inhibition Concentration | In vitro/ In vivo | Cell Line | Intracellular Inhibition | Cytotoxicity | Animal Model | Effective Dose in model organism | Immune Responce | Mechanism of Action | Target | Combination Therapy | Other Activities | Year of Publication | Pubmed ID/ Patent No. |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| antitb_1532 | G13 | QRSVSNAATRVCRTGRSRW | Free | Free | None | Linear | 19 | L | Cationic | Protein derived | Derived from human granulysin protein | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | NA | in vitro | NA | NA | No cytotoxicity | NA | NA | NA | NA | NA | NA | NA | 2015 | 25613372 |
| antitb_1563 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 3.20 ± 0.15 at peptide concentration 64μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1564 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 2.70 ± 0.15 at peptide concentration 64μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1565 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 0.88± 0.30 at peptide concentration 4 μg/ml +INH 0.06 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | INH +peptide | NA | 2004 | 15245864 |
| antitb_1566 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 3.19 ± 0.15 at peptide concentration 64 μg/ml +INH 0.06 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | INH+Peptide | NA | 2004 | 15245864 |
| antitb_1567 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 3.19 ± 0.15 at peptide concentration 4 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1568 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 3.58 ± 0.47 at peptide concentration 8 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1569 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 3.16 ± 0.21 at peptide concentration 16 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1570 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 2.97 ± 0.40 at peptide concentration 32 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1571 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 2.70 ± 0.10 at peptide concentration 64 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1572 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 1.72 ± 0.46 at peptide concentration 128 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1573 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis RM22 | CFU/well 3.08 ± 0.09 at peptide concentration 4 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1574 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 19 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis RM23 | CFU/well 2.97 ± 0.06 at peptide concentration 4 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1575 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 20 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis RM24 | CFU/well 3.11 ± 0.09 at peptide concentration 4 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1578 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis RM22 | CFU/well 3.10 ± 0.08 at peptide concentration 8 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1579 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis RM22 | CFU/well 3.00 ± 0.10 at peptide concentration 16 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1580 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis RM22 | CFU/well 3.05 ± 0.11 at peptide concentration 32 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1581 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis RM22 | CFU/well 2.88 ± 0.06at peptide concentration 64 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1582 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis RM22 | CFU/well 2.71 ± 0.09 at peptide concentration 128 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | NA | NA | 2004 | 15245864 |
| antitb_1603 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv | CFU/well 0.68 ± 0.30 at peptide 64ul + 4 ul of INH | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | Peptide(64 ul) + INH(4 ul) | NA | 2004 | 15245864 |
| antitb_1604 | Protegrin -1 | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-14 | Cyclic | 18 | L | Cationic | Natural | Derived from porcine leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis RM22 | CFU/well 1.99 ± 0.44 at peptide 64ul + 4 ul of INH | in vitro | NA | NA | NA | NA | NA | NA | Bacterial membrane pore formation | NA | Peptide(64 ul) + INH(4 ul) | NA | 2004 | 15245864 |
| antitb_1649 | Tuftsin peptide conjugate compound | SEFAYGSFVRTVSLPV | INH is conjugated | Free | None | Cyclic | 16 | L | Cationic | Natural | Derived from 16-kDa protein of M. tuberculosis and tuftsin-derived peptides | Mycobacterium Tuberculosis | Mycobacterium tuberculosis H37Rv ATCC 27294 | MIC = 2.54 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Cell wall biosynthesis inhibition | NA | Peptide + INH(0.24 ug/ml) | NA | 2009 | 19319854 |
| antitb_1650 | Tuftsin peptide conjugate compound | SEFAYGSFVRTVSLPV | INH is conjugated | Free | None | Cyclic | 16 | L | Cationic | Natural | Derived from 16-kDa protein of M. tuberculosis and tuftsin-derived peptides | Mycobacterium Tuberculosis | Mycobacterium tuberculosis H37Rv ATCC 27294 | MIC = 2.26μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Cell wall biosynthesis inhibition | NA | Peptide + INH(0.24 ug/ml) | NA | 2009 | 19319854 |
| antitb_1672 | Lariatin A | GSQLVYRWVGHSNVIKGP | Free | Free | Alpha carbon of glutamine form amide bond with first glycine and gamma carbon of glutamine involved in side chain formation | Cyclic | 18 | D | Cationic | Natural | Rhodococcus jostii B0171 | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC607 | MIC = 10 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 2007 | 17617692 |
| antitb_1673 | Lariatin B | GSQLVYRWVGHSNVIKGP | Free | Free | Alpha carbon of glutamine form amide bond with first glycine and gamma carbon of glutamine involved in side chain formation | Cyclic | 18 | NA | Cationic | Natural | Rhodococcus jostii B0171 | Mycobacterium smegmatis | Mycobacterium smegmatis ATCC607 | MIC = 10 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 2007 | 17617692 |
| antitb_1708 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-13 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 7632G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
| antitb_1709 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-14 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 9034G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
| antitb_1710 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-15 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis Ra 11170G | Reduction in CFU at 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
| antitb_1711 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-16 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37 Ra | IC50= 5 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
| antitb_1712 | Porcine leucocyte peptide (PG-1) | RGGRLCYCRRRFCVCVGR | Free | Free | Disulphide linkage 6-15 and 8-17 | Cyclic | 18 | L | Cationic | Natural | porcine neutrophil leucocyte | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37 Ra | MIC = 50 μg/ml | in vitro | NA | NA | NA | NA | NA | NA | Microbial membrane disruption | NA | NA | NA | 1996 | 8641802 |
| antitb_1732 | Seq ID No 22 | YPHHFKHRHIPIGGGS | Free | Free | None | Linear | 16 | L | NA | Synthetic | From random peptide libraries diplayed on bacteriophage M14 | Mycobacterium tuberculosis | Mycobacterium tuberculosis | 100 μM completely inhibits the cahpaeron activity of Hsp 16.3 | In vitro | Mouse bone marrow derive dmacrophages and THP-1 | NA | NA | None | NA | NA | Inhibit chaperon activity of heat shock protein 16.3 (Hsp 16.3) | Heat shock protein (Hsp 16.3) | None | None | 2007 | US 2007/003721 |
| antitb_1738 | FKAB-1G | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | 14 % hemolysis at 100 and 25 μM | Mice | No observed toxicity at 5 and 25 mg/kg but minor | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1739 | FKAB-1H | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Acetylation | Addition of CONH-CH2-CH2-NH2 | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | NA | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1740 | FKAB-1L | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Acetylation | Addition of CONH-CH2-CH2-CH2-NH2 | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | NA | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1741 | FKAB-1Ga | G-GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Free | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 20 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | 33.4 % hemolysis at 100 μM and 14.3 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1742 | FKAB-1Gb | G-KL-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Free | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 20 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 43.6 % hemolysis at 100 μM and 24.9 % at 25 μM | Mice | No observed toxicity at 1, 5 and 25 mg/kg | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1744 | FKAB-1Gd | Gaba-F-Tic-Oic-Gaba-K-Tic-Oic-Gaba-F-Tic-Oic-Gaba-K-Tic-KKKK | Acetylation | Amidation | Gaba = Gama aminobutyric acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | 10.8 % hemolysis at 100 μM and 1.0 % at 25 μM | Mice | Minor weight loss, no observed toxicity at 1, 5 an | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1747 | FKAB-1Gg | GF-Tic-GK-Tic-GF-Tic-GK-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid | Linear | 16 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 30 μM | Both | RBC | NA | 6 % hemolysis at 100 μM and 4.9 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1748 | FKAB-1Gg1 | GF-Tic-G-GK-Tic-G-GF-Tic-G-GK-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 30 μM | Both | RBC | NA | 5.70 % hemolysis at 100 μM and 3.80 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1749 | FKAB-1Gf1 | GF-G-Oic-GK-G-Oic-GF-G-Oic-GK-G-KKKK | Acetylation | Amidation | Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 100 μM | Both | RBC | NA | 3.30 % hemolysis at 100 μM and 3.3 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1750 | FKAB-1Gh | GF-F-Oic-GK-F-Oic-GF-F-Oic-GK-F-KKKK | Acetylation | Amidation | Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | RBC | NA | 27.30 % hemolysis at 100 μM and 8.9 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1751 | FKAB-1Gd1 | βAla-F-Tic-Oic-βAla-K-Tic-Oic-βAla-F-Tic-Oic-βAla-K-Tic-KKKK | Acetylation | Amidation | βAla = Beta alanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 1 μM | Both | RBC | NA | 24.4 % hemolysis at 100 μM and 7.4 % at 25 μM | Mice | No observed toxicity at 5 and 25 mg/kg but minor w | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1752 | FKAB-1Gd2 | Ahx-F-Tic-Oic-Ahx-K-Tic-Oic-Ahx-F-Tic-Oic-Ahx-K-Tic-KKKK | Acetylation | Amidation | Ahx = 6-amino hexanoic acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 44.7 % hemolysis at 100 μM and 26.6 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1753 | FKAB-1Gc1 | F-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-KKKKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 17 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 41.3 % hemolysis at 100 μM and 33.5 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1754 | FKAB-1Gi | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 20 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 24.9 % hemolysis at 100 μM and 18.9 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1755 | FKAB-1Gd3 | Gaba-F-Tic-Oic-Gaba-K-Tic-Oic-Gaba-F-Tic-Oic-Gaba-K-Tic-KKKKK | Acetylation | Amidation | Gaba = Gama aminobutyric acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 20 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | RBC | NA | 29.7 % hemolysis at 100 μM and 10.5 % at 25 μM | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1756 | FKAB-1Gj | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-Orn-Orn-Orn-Orn | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1757 | FKAB-1Go | G-Fpa-Tic-Oic-GK-Tic-Oic-G-Fpa-Tic-Oic-GK-Tic-KKKK | Acetylation | Amidation | Fpa = 4-Fluorophenyl alanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 3 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1758 | FKAB-1Gp | GF-Tic-Oic-G-Orn-Tic-Oic-GF-Tic-Oic-G-Orn-Tic-Orn-Orn-Orn-Orn | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |
| antitb_1759 | FKAB-1Gl | Biotin-GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Biotinylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae | MIC = 10 μM | Both | None | NA | not tested | Mice | NA | NA | NA | NA | None | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) | 2012 | US 2012/0197004 |