Primary information |
---|
ID | antitb_1565 |
Peptide Name | Protegrin -1 |
Sequence | RGGRLCYCRRRFCVCVGR |
N-terminal Modification | Free |
C-terminal Modification | Free |
Chemical Modification | Disulphide linkage 6-15 and 8-13 |
Linear/ Cyclic | Cyclic |
Length | 18 |
Chirality | L |
Nature | Cationic |
Source | Natural |
Origin | Derived from porcine leucocyte |
Species | Mycobacterium tuberculosis |
Strain | Mycobacterium tuberculosis H37Rv |
Inhibition Concentartion | CFU/well 0.88± 0.30 at peptide concentration 4 μg/ml +INH 0.06 μg/ml |
In vitro/In vivo | in vitro |
Cell Line | NA |
Inhibition Concentartion | NA |
Cytotoxicity | NA |
In vivo Model | NA |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | Bacterial membrane pore formation |
Target | NA |
Combination Therapy | INH +peptide |
Other Activities | NA |
Pubmed ID | 15245864 |
Year of Publication | 2004 |
3-D Structure | NA |