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βAla-F-Tic-Oic-βAla-K-Tic-Oic-βAla-F-Tic-Oic-βAla-K-Tic-KKKK details |
| Primary information | |
|---|---|
| ID | antitb_1751, |
| Name | US 2012/0197004 |
| N-Terminal modification | FKAB-1Gd1 |
| C-Terminal Modification | βAla-F-Tic-Oic-βAla-K-Tic-Oic-βAla-F-Tic-Oic-βAla-K-Tic-KKKK |
| Chemical Modification | Acetylation |
| Linear/Cyclic | Amidation |
| Length | βAla = Beta alanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Hydrophobic |
| Species | Synthetic |
| Inhibition Concentration | Mycobacterium ranae |
| In Vitro/ In vivo | Mycobacterium ranae |
| Cell Line | MIC = 1 μM |
| Inhibition Concentration | Both |
| Sequence | 2012 |
| Cytotoxicity | RBC |
| In vivo Model | NA |
| Lethal Dose | 24.4 % hemolysis at 100 μM and 7.4 % at 25 μM |
| Immune Responce | Mice |
| Mechanism of Action | No observed toxicity at 5 and 25 mg/kg but minor w |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | None |
| Year of Publication | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1792, |
| Name | 17547385 |
| N-Terminal modification | Peptide-36 |
| C-Terminal Modification | βAla-F-Tic-Oic-βAla-K-Tic-Oic-βAla-F-Tic-Oic-βAla-K-Tic-KKKK |
| Chemical Modification | Acetylation |
| Linear/Cyclic | Amidation |
| Length | βAla= beta-alanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Amphipathic, Hydrophobic |
| Species | Synthetic |
| Inhibition Concentration | Mycobacterium ranae |
| In Vitro/ In vivo | Mycobacterium ranae (ATCC 110) |
| Cell Line | MIC = 1 µM or 2.5 µg/mL |
| Inhibition Concentration | Both |
| Sequence | 2007 |
| Cytotoxicity | RBC |
| In vivo Model | NA |
| Lethal Dose | 24.4 % and 7.4 % hemolytic activity at 100 µM and 25 µM peptide respectively |
| Immune Responce | mouse skin wound healing model |
| Mechanism of Action | Acute toxicity was observed at dose of 125 mg/kg |
| Target | Stimulate innate immune system |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) |
| Tertiary Structure (Technique) | Not Predicted), |