Primary information |
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ID | antitb_1742, |
Name | US 2012/0197004 |
N-Terminal modification | FKAB-1Gb |
C-Terminal Modification | G-KL-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK |
Chemical Modification | Free |
Linear/Cyclic | Amidation |
Length | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid |
Chirality | Linear |
Nature | 20 |
Source | L |
Origin | Hydrophobic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium ranae |
In Vitro/ In vivo | Mycobacterium ranae |
Cell Line | MIC = 3 μM |
Inhibition Concentration | Both |
Sequence | 2012 |
Cytotoxicity | RBC |
In vivo Model | NA |
Lethal Dose | 43.6 % hemolysis at 100 μM and 24.9 % at 25 μM |
Immune Responce | Mice |
Mechanism of Action | No observed toxicity at 1, 5 and 25 mg/kg |
Target | NA |
Combination Therapy | NA |
Other activities | NA |
PMID | None |
Year of Publication | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) |
Tertiary Structure (Technique) | Not Predicted), |