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GF-F-Oic-GK-F-Oic-GF-F-Oic-GK-F-KKKK details |
Primary information | |
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ID | antitb_1750, |
Name | US 2012/0197004 |
N-Terminal modification | FKAB-1Gh |
C-Terminal Modification | GF-F-Oic-GK-F-Oic-GF-F-Oic-GK-F-KKKK |
Chemical Modification | Acetylation |
Linear/Cyclic | Amidation |
Length | Oic = Octahydroindolecarboxylic acid |
Chirality | Linear |
Nature | 19 |
Source | L |
Origin | Hydrophobic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium ranae |
In Vitro/ In vivo | Mycobacterium ranae |
Cell Line | MIC = 10 μM |
Inhibition Concentration | Both |
Sequence | 2012 |
Cytotoxicity | RBC |
In vivo Model | NA |
Lethal Dose | 27.30 % hemolysis at 100 μM and 8.9 % at 25 μM |
Immune Responce | Mice |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | NA |
Other activities | NA |
PMID | None |
Year of Publication | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
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ID | antitb_1791, |
Name | 17547385 |
N-Terminal modification | Peptide-35 |
C-Terminal Modification | GF-F-Oic-GK-F-Oic-GF-F-Oic-GK-F-KKKK |
Chemical Modification | Acetylation |
Linear/Cyclic | Amidation |
Length | Oic = Octahydroindolecarboxylic acid |
Chirality | Linear |
Nature | 19 |
Source | L |
Origin | Amphipathic, Hydrophobic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium ranae |
In Vitro/ In vivo | Mycobacterium ranae (ATCC 110) |
Cell Line | MIC = 10 µM or 24 µg/mL |
Inhibition Concentration | Both |
Sequence | 2007 |
Cytotoxicity | RBC |
In vivo Model | NA |
Lethal Dose | 27.30 % and 8.9 % hemolytic activity at 100 µM and 25 µM peptide respectively |
Immune Responce | NA |
Mechanism of Action | NA |
Target | Stimulate innate immune system |
Combination Therapy | NA |
Other activities | NA |
PMID | NA |
Year of Publication | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) |
Tertiary Structure (Technique) | Not Predicted), |