Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID1117 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability64.9±8.8% degraded | Tissue SampleInterior skin surface of dermatomed skin (DS) of porcine | PUBMED ID19486932 |
| ID1118 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability15±4.1% degraded | Tissue SampleInterior skin surface of heat separated epidermis (HSE) of porcine | PUBMED ID19486932 |
| ID1119 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability100% degraded | Tissue SampleInterior skin surface of full thickness skin (FTS) of porcine | PUBMED ID19486932 |
| ID1120 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability87.8±4.4% degraded | Tissue SampleInterior skin surface of dermatomed skin (DS) of porcine | PUBMED ID19486932 |
| ID1121 | SequencepGlu-HWSYwLRPG | NameTriptorelin | Nature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonist | AssayFranz diffusion cell, HPLC | Tissue permeability51.3±6% degraded | Tissue SampleInterior skin surface of heat separated epidermis (HSE) of porcine | PUBMED ID19486932 |
| ID1194 | SequenceMpr-YFQNCPrG | NameDesmopressin | Nature of peptide or cargoIt is a peptide hormone that is used chiefly for treatment of enuresis | AssayRadioimmunoassay | Tissue permeability10 ng/ml serum conc. of desmopressin after ~100 min of coated microneedle array application | Tissue SampleLateral skin areas of the thorax of hairless guinea pigs | PUBMED ID15212882 |
| ID1195 | SequenceMpr-YFQNCPrG | NameDesmopressin | Nature of peptide or cargoIt is a peptide hormone that is used chiefly for treatment of enuresis | AssayRadioimmunoassay | Tissue permeability1 ng/ml serum conc. of desmopressin after ~250 min of coated microneedle array application | Tissue SampleLateral skin areas of the thorax of hairless guinea pigs | PUBMED ID15212882 |
| ID1196 | SequenceMpr-YFQNCPrG | NameDesmopressin | Nature of peptide or cargoIt is a peptide hormone that is used chiefly for treatment of enuresis | AssayRadioimmunoassay | Tissue permeability0.8 ng/ml serum conc. of desmopressin after ~350 min of coated microneedle array application | Tissue SampleLateral skin areas of the thorax of hairless guinea pigs | PUBMED ID15212882 |
| ID1204 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 1.99 ± 2.04 µg h−1 cm−2 at 100% DC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1205 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 6.47 ± 0.87 µg h−1 cm−2 at 75% DC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1206 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 0.96 ± 0.79 µg h−1 cm−2 at 50% pulsed DC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1207 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 3.33 ± 1.04 µg h−1 cm−2 at 75%+/25%- AC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1208 | SequencepGlu-HWSY-D-2-Nal-LRPG | NameNafarelin | Nature of peptide or cargoPeptides containing closely juxtapositioned cationic and lipohilic residues are able to inhibit their own transport across the skin even under the influence of iontophoretic current. | AssayHPLC | Tissue permeabilityNafarelin flux= 0.15 ± 0.09 µg h−1 cm−2 at 50%+/50%- AC | Tissue SampleHuman cadaver skin | PUBMED ID14757511 |
| ID1218 | SequenceI/V-CLe-I/V-K-orn-I/V-fHdN | NameBacitracin | Nature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids. | AssayFluorescein-labeled bacitracin and confocal microscopy, HPLC | Tissue permeabilityBacitracin Cumulative Amount(µg/cm2)=42.3±3.8 | Tissue SampleHuman epidermis from abdominal sites of Caucasian females | PUBMED ID12712421 |
| ID1219 | SequenceI/V-CLe-I/V-K-orn-I/V-fHdN | NameBacitracin | Nature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids. | AssayFluorescein-labeled bacitracin and confocal microscopy, HPLC | Tissue permeabilityBacitracin Cumulative Amount(µg/cm2)=80.2±4.7 | Tissue SampleHuman epidermis from abdominal sites of Caucasian females | PUBMED ID12712421 |
| ID1220 | SequenceI/V-CLe-I/V-K-orn-I/V-fHdN | NameBacitracin | Nature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids. | AssayFluorescein-labeled bacitracin and confocal microscopy, HPLC | Tissue permeabilityBacitracin Cumulative Amount(µg/cm2)=44.1±4 | Tissue SampleHuman epidermis from abdominal sites of Caucasian females | PUBMED ID12712421 |
| ID1221 | SequenceI/V-CLe-I/V-K-orn-I/V-fHdN | NameBacitracin | Nature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids. | AssayFluorescein-labeled bacitracin and confocal microscopy, HPLC | Tissue permeabilityBacitracin Cumulative Amount(µg/cm2)=82.1±4.4 | Tissue SampleHuman epidermis from abdominal sites of Caucasian females | PUBMED ID12712421 |
| ID1222 | SequenceI/V-CLe-I/V-K-orn-I/V-fHdN | NameBacitracin | Nature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids. | AssayFluorescein-labeled bacitracin and confocal microscopy, HPLC | Tissue permeabilityBacitracin Cumulative Amount(µg/cm2)=52.8±4.4 | Tissue SampleHuman epidermis from abdominal sites of Caucasian females | PUBMED ID12712421 |
| ID1223 | SequenceI/V-CLe-I/V-K-orn-I/V-fHdN | NameBacitracin | Nature of peptide or cargoBactericidal antibiotic often used topically. It is a cyclic peptide that contains positively and negatively charged lateral chains at neutral pH and is composed of a mixture of L and D amino acids. | AssayFluorescein-labeled bacitracin and confocal microscopy, HPLC | Tissue permeabilityBacitracin Cumulative Amount(µg/cm2)=95±2.9 | Tissue SampleHuman epidermis from abdominal sites of Caucasian females | PUBMED ID12712421 |
| ID1289 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 57% (32 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1290 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 55% (23 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1291 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 54% (21 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1292 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 56% (20 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1293 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 58% (16 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1294 | SequenceGrGDIPASSKGGGGS rLLLLLLr | NameRGD peptide matrix | Nature of peptide or cargoActs as a temporary topical synthetic extracellular matrix that presents attachment sites for cells and substitutes for the damaged natural matrix and provides support for cell ingrowth into the ulcer site | AssayAt each visit, the ulcer was cleansed, debrided as needed, traced on acetate film for size determination, and photographed. Ulcer area was determined by computerized planimetry. Regression analysis was also done. | Tissue permeabilityMean percent ulcer closure at study endpoint in ulcers of varying baseline durations ~ 61% (14 patients) | Tissue SamplePatients were eligible for inclusion in the study if they presented with isolated full-thickness lower leg or ankle ulcers that did not involve bone or tendon and had persisted at least for one month. The peptide matrix is topically applied to the ulcers which were situated at the ankle | PUBMED ID8080985 |
| ID1302 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone | AssayLight and electron microscopy | Tissue permeability10-7 to 10-12 concentrations turned yellow hair brown | Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect | PUBMED ID3684299 |
| ID1303 | SequenceNle-EHfRWGK | Name[Nle4, D-Phe7]-alpha-MSH4-11 | Nature of peptide or cargoNot mentioned | AssayLight and electron microscopy | Tissue permeability10-8 to 10-14 concentrations turned yellow hair brown | Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect | PUBMED ID3684299 |
| ID1304 | SequenceNle-EHfRWG | Name[Nle4, D-Phe7]-alpha-MSH4-10 | Nature of peptide or cargoNot mentioned | AssayLight and electron microscopy | Tissue permeability10-8 to 10-14 concentrations turned yellow hair brown | Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect | PUBMED ID3684299 |
| ID1306 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7]-α-MSH | Nature of peptide or cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice | AssayElectron microscopy and Light microscopy | Tissue permeabilityConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application. | Tissue Sampledorsal trunk of mice (C57BL/6JA y) | PUBMED ID3624899 |
| ID1307 | SequenceNle-EHfFRWGK | NameAc-[Nle4, D-Phe7]-α- MSH4–11-NH2 | Nature of peptide or cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice | AssayElectron microscopy and Light microscopy | Tissue permeabilityConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application. | Tissue Sampledorsal trunk of mice (C57BL/6JA y) | PUBMED ID3624899 |
| ID1308 | SequenceNle-EH-FRWG | NameAc-[Nle4, D-Phe7]-α-MSH4–10-NH2 | Nature of peptide or cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice | AssayElectron microscopy and Light microscopy | Tissue permeabilityConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application. | Tissue Sampledorsal trunk of mice (C57BL/6JA y) | PUBMED ID3624899 |
| ID1310 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7)-a-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone | AssayElectron microscopic examination | Tissue permeabilityMinimal effective dose=10-12M. It is transdermally delivered systemically to hair follicles throughout the body to induce follicular melanogenesis. Microscopic examination revealed eumelanin within hair bulbs by 24 hours after topical application of the analogue. | Tissue SamplePosterior dorsum of mice (C57BL/6JA y) | PUBMED ID3573985 |
| ID1311 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayFrog Skin Bioassay | Tissue permeabilityPercent positive samples of transdermal delivery :65% (15/23) | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | PUBMED ID2845208 |
| ID1312 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayRadioimmunoassay | Tissue permeabilityPercent positive samples of transdermal delivery :85% (11/13) | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | PUBMED ID2845208 |
| ID1313 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayFrog Skin Bioassay | Tissue permeabilityPercent positive samples of transdermal delivery :6.6% (1/15) | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of mature Sprague Dawley rats. | PUBMED ID2845208 |
| ID1314 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayRadioimmunoassay | Tissue permeabilityPercent positive samples of transdermal delivery :11.8% (2/17) | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of mature Sprague Dawley rats. | PUBMED ID2845208 |
| ID1315 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayFrog Skin Bioassay, radioimmunoassay and microscopy | Tissue permeabilityTransdermal delivery of 0.05% | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | PUBMED ID2845208 |
| ID1316 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayFrog Skin Bioassay, radioimmunoassay and microscopy | Tissue permeabilityTransdermal delivery of 0.08% | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | PUBMED ID2845208 |
| ID1329 | SequenceYaGFL | NameYGGFL analogue | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability1% aGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1330 | SequenceYaGFL | NameYGGFL analogue | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability18.5% YaGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1331 | SequenceYaGFL | NameYGGFL analogue | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability3.75% aGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1332 | SequenceYaGFL | NameYGGFL analogue | Nature of peptide or cargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans. | AssayHPLC | Tissue permeability10.75% YaGFL of the parent peptide | Tissue SampleFull-thickness hairless mouse skin was excised from the fresh carcasses | PUBMED ID2293206 |
| ID1333 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7)-a-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays | AssayFrog Skin Bioassay | Tissue permeabilityHead and neck(85.7%), Trunk(8.7%),Leg(25%) | Tissue SampleStratum corneum of human skin samples (obtained from freshly excised surgical specimens) | PUBMED ID2155969 |
| ID1334 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7)-a-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays | AssayRadioimmunoassay | Tissue permeabilityHead and neck(78.6%), Trunk(8.8%),Leg(33.3%) | Tissue SampleStratum corneum of human skin samples (obtained from freshly excised surgical specimens) | PUBMED ID2155969 |
| ID1405 | SequencerPKPQQwFwLL | NameSpantide | Nature of peptide or cargoEffectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury. | AssayRadioimmunoassay, HPLC | Tissue permeabilitySystemic uptake corresponds to a serum concentration peak of 4.5*10-9M after 15 minutes | Tissue SampleLeft eye of pigmented rabbits of either sex and weighing 2-3 kg | PUBMED ID1689665 |
| ID1406 | SequencerPKPQQwFwLL | NameSpantide | Nature of peptide or cargoEffectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury. | AssayRadioimmunoassay, HPLC | Tissue permeabilitySystemic uptake corresponds to a serum concentration peak of 1*10-8M after 15 minutes and intraoccular uptake corresponded to a plateau at 140-150ng/ml for 1-3 hours after completion of application | Tissue SampleLeft eye of pigmented rabbits of either sex and weighing 2-3 kg | PUBMED ID1689665 |
| ID1407 | SequencerPKPQQwFwLL | NameSpantide | Nature of peptide or cargoEffectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury. | AssayRadioimmunoassay, HPLC | Tissue permeabilitySystemic uptake corresponds to a serum concentration peak of 1*10-7M after 15 minutes and intraoccular uptake corresponded to a plateau at 1.3-1.5µg/ml for 90-240 minutes after completion of application giving an approximate concentration of 10m6 M in the aqueous humor. | Tissue SampleLeft eye of pigmented rabbits of either sex and weighing 2-3 kg | PUBMED ID1689665 |
| ID1478 | SequenceYaGFM | Name[D-ala2]-met-enkephalinamide | Nature of peptide or cargoA potent opioid peptide | AssayRadioactive determination | Tissue permeabilityFluid: Tears- degraded peptide=4250pmoles/ml fluid, Percent of recovered enkephalin attributable to degradation products=0% | Tissue SampleSuperior limbus of both eyes of each male, albino New Zealand rabbits | PUBMED ID3503119 |
| ID1479 | SequenceYaGFM | Name[D-ala2]-met-enkephalinamide | Nature of peptide or cargoA potent opioid peptide | AssayRadioactive determination | Tissue permeabilityFluid: Tears- degraded peptide=950pmoles/ml fluid, Percent of recovered enkephalin attributable to degradation products=0% | Tissue SampleSuperior limbus of both eyes of each male, albino New Zealand rabbits | PUBMED ID3503119 |
| ID1480 | SequenceYaGFM | Name[D-ala2]-met-enkephalinamide | Nature of peptide or cargoA potent opioid peptide | AssayRadioactive determination | Tissue permeabilityTissue: Conjunctiva- intact peptide=312pmoles/g tissue, degraded peptide=342pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=0.4% | Tissue SampleSuperior limbus of both eyes of each male, albino New Zealand rabbits | PUBMED ID3503119 |