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Details of TopicalPdb ID 1306

PRIMARY INFORMATION
ID1306
PMID3624899
Year1987
SequenceSYS-Nle-EHfRWGKPV
Name(Nle4, D-Phe7]-α-MSH
Length13
N-Terminal ModificationAcetylation
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityMix
Chemical ModificationNle=Norleucine
Origin of Peptideanalogue of alpha-MSH
Nature of Peptide/Cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayElectron microscopy and Light microscopy
EnhancerPEG ointment base vehicle was used
Properties of enhancerNot mentioned
ConcentrationPEG ointment base(26% PEG 400 and 74% PEG 3350 ) was liquified on heating.The melanotropins were dissolved in this vehicle and 0.5 ml aliquots, the amount to be applied daily to each animal, were divided before the vehicle resolidified.
Incubation time7 days
Tissue permeability (value with units)Concentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application.
Tissue Sampledorsal trunk of mice (C57BL/6JA y)
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N
[C@@H](CCCC)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](Cc1nc[nH]c1)C(=O)N[C@@H]
(Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C
(=O)NCC(=O)N[C@@H](CCCC[NH3])C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N