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Details of TopicalPdb ID 1302

PRIMARY INFORMATION
ID1302
PMID3684299
Year1987
SequenceSYS-Nle-EHfRWGKPV
Name[Nle4, D-Phe7]-alpha-MSH
Length13
N-Terminal ModificationAcetylation
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityMix
Chemical ModificationNle=Norleucine
Origin of PeptideDerived from α-MSH
Nature of Peptide/CargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone
MechanismIt stimulates pheomelanin-to-eumelanin shift in the follicular melanocytes
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayLight and electron microscopy
EnhancerHairs were plucked as a pretreatment control
Properties of enhancerNot mentioned
Concentration0.5 ml aliquots of melanotropins in poly-ethelene glycol ointment base (26% PEG '400 and 74% PEG 3350
Incubation timeOnce in 24 hours for 7 days.
Tissue permeability (value with units)10-7 to 10-12 concentrations turned yellow hair brown
Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C
(=O)N[C@@H](CCCC)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](Cc1nc[nH]c1)C(=O)N
[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C
(=O)NCC(=O)N[C@@H](CCCC[NH3])C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N