Browse result page of TopicalPdb

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The total number entries retrieved from this search are

ID	Sequence	Name	Nature of peptide or cargo	Assay	Tissue permeability	Tissue Sample	PUBMED ID
ID1009	SequenceRRRRRRRRRRRLILV LLAI	Name11R-No. 10	Nature of peptide or cargoMelanogenesis inhibitory peptide	AssayConfocal microscope	Tissue permeabilityWhen TMR-11R was topically applied for 24 h, the signals were only observed on the surface of the skin. In contrast, 12 h later, strong signals were detected showing that TMR-11R had arrived at the skin basal layer. Moreover, 24 and 48 hours later, the signals had spread out more and were stronger in both epidermis and dermis	Tissue SampleSkin from the back of a brown guinea pig	PUBMED ID24602570
ID1016	SequenceGKKKKKKKRRRRRRRR	NameR16 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 21.43 ± 1.32 , Q48 (mg) 856.29 ± 39.50 Drug content in skin (mg/cm2) 151 ± 4.64	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1017	SequenceGKKKKKKKRRRRRRRR	NameR16 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 23.46 ± 2.04 , Q48 (mg) 1106.03 ± 53.80 Drug content in skin (mg/cm2) 155 ± 4.85	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1018	SequenceGKKKKKKKRRRRRRRR	NameR16 (arginine-terminated peptide dendrimers)	Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups	AssayFranz diffusion cell	Tissue permeabilityFlux (mg/cm2/h) 27.16 ± 2.65, Q48 (mg) 1256.61 ± 55.70, Drug content in skin (mg/cm2) 156 ± 6.26	Tissue SampleHuman epidermal skin	PUBMED ID24134794
ID1023	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityTP could not pass through the skin due to the charge repulsion effect between the negative charge of the TP and the negative charge of the skin	Tissue SampleAbdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1024	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityCumulative amounts0.10± 0.01 µg/cm2 and fluxes 0.60 ± 0.06 µg/cm2·h	Tissue SampleAcceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1025	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityCumulative amounts 0.31 ± 0.04 µg/cm2 and fluxes 1.86 ± 0.24 µg/cm2·h	Tissue SampleAbdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1026	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityCumulative amounts 1.02 ± 0.05 µg/cm2 and fluxes 6.13± 0.28 µg/cm2·h	Tissue SampleAcceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1027	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell	Tissue permeabilityCumulative amounts 4.29 ± 0.40 µg/cm2 and fluxes 25.73 ± 2.40 µg/cm2·h	Tissue SampleAbdominal skin of Sprague–Dawley rats	PUBMED ID23311648
ID1077	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell, HPLC	Tissue permeabilityCumulative amounts 0.20 ± 0.05 mg/cm2 and fluxes 0.20 ± 0.05 mg/cm2·h	Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats	PUBMED ID22564052
ID1078	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell, HPLC	Tissue permeabilityCumulative amounts 0.43 ± 0.04 mg/cm2 and fluxes 0.14 ± 0.01 mg/cm2·h	Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats	PUBMED ID22564052
ID1079	SequenceGRKKRRQRRRPPQRKC	NameTat	Nature of peptide or cargoCell penetrating peptide	AssayVertical Franz diffusion cell, HPLC	Tissue permeabilityCumulative amounts 0.59 ± 0.12 mg/cm2 and fluxes 0.10 ± 0.02 mg/cm2·h	Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats	PUBMED ID22564052
ID1083	SequenceRQIKIWFQNRRMKWKK	NamePenetratin (PEN)	Nature of peptide or cargoPenetrate through cell and nucleus membranes	AssayFranz diffusion cell system, HPLC with photodiode array detector	Tissue permeability2-fold higher	Tissue SamplePorcine ear skin	PUBMED ID22306174
ID1084	SequenceRQIKIWFQNRRMKWKK	NamePenetratin (PEN)	Nature of peptide or cargoPenetrate through cell and nucleus membranes	AssayFranz diffusion cell system, HPLC with photodiode array detector	Tissue permeability2.8 wt% of the initial amount	Tissue SamplePorcine ear skin	PUBMED ID22306174
ID1085	SequenceRQIKIWFQNRRMKWKK	NamePenetratin (PEN)	Nature of peptide or cargoPenetrate through cell and nucleus membranes	AssayThe scotch tape method	Tissue permeability0.35 wt% of Na-DFC	Tissue SampleSC skin	PUBMED ID22306174
ID1086	SequenceRQIKIWFQNRRMKWKK	NamePenetratin (PEN)	Nature of peptide or cargoPenetrate through cell and nucleus membranes	AssayThe scotch tape method	Tissue permeability0.72 wt% of Na-DFC	Tissue SampleSC skin	PUBMED ID22306174
ID1087	SequenceRQIKIWFQNRRMKWKK	NamePenetratin (PEN)	Nature of peptide or cargoPenetrate through cell and nucleus membranes	AssayThe scotch tape method	Tissue permeability0.3 wt% of Na-DFC	Tissue SampleE + D skin	PUBMED ID22306174
ID1088	SequenceRQIKIWFQNRRMKWKK	NamePenetratin (PEN)	Nature of peptide or cargoPenetrate through cell and nucleus membranes	AssayThe scotch tape method	Tissue permeability0.57 wt% of Na-DFC	Tissue SampleE + D skin	PUBMED ID22306174
ID1104	SequenceKWLNALLHHGLNCAK GVLA	NameHG1	Nature of peptide or cargoAntimicrobial	AssayConfocal microscopy, HPLC	Tissue permeabilitySignificant permeability of the peptide can be seen in confocal images	Tissue SampleICR mice skin	PUBMED ID21220538
ID1105	SequenceACSSSPSKHCGGRRR RRRRR	NameTD1-R8	Nature of peptide or cargoMITF-siRNA inhibition of melanin synthesis and melanoma cell apoptosis.	AssayLaser scanning confocal microscopy	Tissue permeabilitySignificant penetration of carboxyfluorescein-labeled MITF-siR can be seen in confocal images of whole epidermis and partial dermis	Tissue SampleHair shaved back of BALB/c mice	PUBMED ID21119619
ID1106	SequenceACSSSPSKHCGGRRR RRRRR	NameTD1-R8	Nature of peptide or cargoMITF-siRNA inhibition of melanin synthesis and melanoma cell apoptosis.	AssayReal-time PCR	Tissue permeabilityThe cream penetrated the mouse skin and mouse skin exhibited a 52% and 34% decrease in MITF and TYR mRNA levels, respectively (versus naive control).	Tissue SampleHair shaved back of BALB/c mice	PUBMED ID21119619
ID1108	SequenceRALARALARALRALAR	NameRALA	Nature of peptide or cargoBased on a family of amphipatic peptides that exhibit improved membrane permeability belongs to a synthetic family of CPEs.	AssayFranz diffusion cell, HPLC	Tissue permeability60% of applied dose	Tissue SampleStratum corneum of ear of porcine	PUBMED ID20189781
ID1114	SequenceFLGGLIKIVPAMICA VTKKC	NameRanalexin	Nature of peptide or cargoAntimicrobial	AssayFranz diffusion cell	Tissue permeabilityIn combination these compounds reduced viable bacteria by 2.83 ± 0.26 log10 CFU	Tissue SampleAbdominal skin from a 38-year-old white female donor	PUBMED ID19709343
ID1115	SequenceFLGGLIKIVPAMICA VTKKC	NameRanalexin	Nature of peptide or cargoAntimicrobial	AssayFranz diffusion cell	Tissue permeabilityRanalexin (100 mg l-1) reduced viable MRSA252 by 0.13 ± 0.06 log10 CFU	Tissue SampleAbdominal skin from a 38-year-old white female donor	PUBMED ID19709343
ID1140	SequenceTRWYSMKKTTMKIIP FNRL	NameHaptide	Nature of peptide or cargoImprove the cell penetration and subsequent presentation of the antigen.	AssayAnti-LT antibodies determination by ELISA	Tissue permeabilitySignificant increase in antibody titer (anti-LT) in the serum of mice on topical application with HR-gp100H	Tissue SampleEars of BALB/c mice	PUBMED ID17493711
ID1188	SequenceCGSGVRGDFGSLAPR VARQL	NamePeptide 141–159 from the VP1 protein of serotype A12	Nature of peptide or cargoElicits virus neutralising antibodies in mice after transcutaneous immunisation	AssayELISA	Tissue permeabilityLog10 antibody titres=2.7 after first booster	Tissue SampleAbdominal skin of BALB/c mice	PUBMED ID15734548
ID1189	SequenceCGSGVRGDFGSLAPR VARQL	NamePeptide 141–159 from the VP1 protein of serotype A12	Nature of peptide or cargoElicits virus neutralising antibodies in mice after transcutaneous immunisation	AssayELISA	Tissue permeabilityLog10 antibody titres=3.8 after second booster	Tissue SampleAbdominal skin of BALB/c mice	PUBMED ID15734548
ID1190	SequenceCGSGVRGDFGSLAPR VARQL	NamePeptide 141–159 from the VP1 protein of serotype A12	Nature of peptide or cargoElicits virus neutralising antibodies in mice after transcutaneous immunisation	AssayELISA	Tissue permeabilityLog10 antibody titres=4.5 after third booster	Tissue SampleAbdominal skin of BALB/c mice	PUBMED ID15734548
ID1191	SequenceCGSGVRGDFGSLAPR VARQL	NamePeptide 141–159 from the VP1 protein of serotype A12	Nature of peptide or cargoElicits virus neutralising antibodies in mice after transcutaneous immunisation	AssayNeutralisation assay	Tissue permeabilityNeutralisation indices of anti-peptide antibody responses=2.5 after first booster	Tissue SampleAbdominal skin of BALB/c mice	PUBMED ID15734548
ID1192	SequenceCGSGVRGDFGSLAPR VARQL	NamePeptide 141–159 from the VP1 protein of serotype A12	Nature of peptide or cargoElicits virus neutralising antibodies in mice after transcutaneous immunisation	AssayNeutralisation assay	Tissue permeabilityNeutralisation indices of anti-peptide antibody responses=2.1 after second booster	Tissue SampleAbdominal skin of BALB/c mice	PUBMED ID15734548
ID1193	SequenceCGSGVRGDFGSLAPR VARQL	NamePeptide 141–159 from the VP1 protein of serotype A12	Nature of peptide or cargoElicits virus neutralising antibodies in mice after transcutaneous immunisation	AssayNeutralisation assay	Tissue permeabilityNeutralisation indices of anti-peptide antibody responses=2.7 after third booster	Tissue SampleAbdominal skin of BALB/c mice	PUBMED ID15734548
ID1392	Sequencelsaydpvdypysnsfakc	NameRetro-inverso HA 91-108	Nature of peptide or cargoAntigenic properties with increased resistance to proteolytic activity and consequently longer persistence in vivo	AssayELISA	Tissue permeabilityRetro-inverso peptide induced high levels of serum IgG and lung IgA antibodies	Tissue SampleNasal cavity of mouse	PUBMED ID12220890