ID | 1192 | |
PMID | 15734548 | |
Year | 2005 | |
Sequence | CGSGVRGDFGSLAPR VARQL | |
Name | Peptide 141–159 from the VP1 protein of serotype A12 | |
Length | 20 | |
N-Terminal Modification | Conjugated to BSA | |
C-Terminal Modification | Free | |
Linear/ Cyclic | Linear | |
Chirality | L | |
Chemical Modification | None | |
Origin of Peptide | Synthetic peptide representing residues 141–159 from the GH loop of VP1 protein of foot-and-mouth disease virus | |
Nature of Peptide/Cargo | Elicits virus neutralising antibodies in mice after transcutaneous immunisation | |
Mechanism | Not mentioned | |
Cargo Sequence/Structure | None | |
Name of cargo | Not applicable | |
Assay | Neutralisation assay | |
Enhancer | Peptide conjugated to BSA together with Cholera toxin | |
Properties of enhancer | Elicited anti-peptide antibody responses with strong virus neutralising activity | |
Concentration | 30 µl of 100 µg 141–159 peptide conjugated to BSA together with 100 µg Cholera Toxin | |
Incubation time | Booster applications with the same dose and formulation were given on days 21, 42, and 63. | |
Tissue permeability (value with units) | Neutralisation indices of anti-peptide antibody responses=2.1 after second booster | |
Tissue Sample | Abdominal skin of BALB/c mice | |
Ex vivo/In vivo/In vitro | in vivo | |
STRUCTURE |
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SMILES | N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C(C)C)C (=O)N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1) C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O) N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C(C)C)C(=O) N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C=O |