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Details of TopicalPdb ID 1104

PRIMARY INFORMATION
ID1104
PMID21220538
Year2011
SequenceKWLNALLHHGLNCAK
GVLA
NameHG1
Length19
N-Terminal ModificationFree
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideDerived from a natural AMP (halocidin) detected in the hemocytes of a tunicate, Halocynthia aurantium
Nature of Peptide/CargoAntimicrobial
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayConfocal microscopy, HPLC
EnhancerNone
Properties of enhancerNot applicable
Concentration20µl of 5% (w/v) HG1 solution
Incubation time12 hours
Tissue permeability (value with units)Significant permeability of the peptide can be seen in confocal images
Tissue SampleICR mice skin
Ex vivo/In vivo/In vitroex vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CCCC[NH3])C(=O)N[C@@H](Cc1c[nH]
c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC
(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)
N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1nc[nH]c1)C(=O)N[C@@H]
(CC1=CNCN1)C(=O)NCC(=O)N[C@@H](CC
(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]
(CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCC[NH3])
C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H]
(CC(C)C)C(=O)N[C@@H](C)C(=O)N